Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors

Inhibition of sperm phosphodiesterase (PDE) has been shown to increase cAMP concentrations and stimulate motility and the acrosome reaction. While several PDE genes exist in mammals, little is known about the physiological role of PDE forms expressed in human spermatozoa. Using type-selective inhibi...

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Veröffentlicht in:	Human reproduction (Oxford) 1998-05, Vol.13 (5), p.1248-1254
Hauptverfasser:	Fisch, J D, Behr, B, Conti, M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases - physiology 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases - physiology Acrosome - drug effects Acrosome - physiology Biological and medical sciences Cyclic Nucleotide Phosphodiesterases, Type 1 Cyclic Nucleotide Phosphodiesterases, Type 4 Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans In Vitro Techniques Infertility, Male - physiopathology Infertility, Male - therapy Male Mammalian male genital system Models, Biological Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases Quinazolines - pharmacology Reproductive Techniques Sperm Motility - drug effects Sperm Motility - physiology Spermatozoa - drug effects Spermatozoa - enzymology Spermatozoa - physiology Subcellular Fractions - enzymology Vertebrates: reproduction
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