Inhibition of 25-hydroxyvitamin D3 production by 1, 25-dihydroxyvitamin D3 in rats

The regulation of the hepatic vitamin D3 25-hydroxylase enzyme system by 1,25-dihydroxyvitamin D3 was examined using male rats. Circulating 25-hydroxyvitamin D3 levels decreased in response to increasing doses of 1,25-dihydroxyvitamin D3 as determined by HPLC and serum protein binding assay. A maxim...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1998-07, Vol.355 (1), p.77-83
Hauptverfasser:	Reinholz, G G, DeLuca, H F
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism Animals Calcifediol - biosynthesis Calcifediol - blood Calcitriol - pharmacology Calcium - blood Chromatography, High Pressure Liquid Hydroxylation In Vitro Techniques Liver - drug effects Liver - metabolism Male Rats Rats, Sprague-Dawley Reproducibility of Results
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