A New Model of Endovascularly Induced Renal Artery Stenosis in Normocholesterolemic Versus Hypercholesterolemic Rabbits
RATIONALE AND OBJECTIVES.The authors determine the feasibility of creating renal artery stenosis by overdilatation and deendothelialization and compare the model in normocholesterolemic versus hypercholesterolemic rabbits. METHODS.Thirty male New Zealand White rabbits were randomized into two groups...
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| Veröffentlicht in: | Investigative radiology 1998-06, Vol.33 (6), p.322-328 |
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| creator | LE BLANCHE, ALAIN-FERDINAND SIBONY, MATHILDE KOLLAR, ATTILA CALLARD, PATRICE BIGOT, JEAN-MICHEL BOUDGHENE, FRANK |
| description | RATIONALE AND OBJECTIVES.The authors determine the feasibility of creating renal artery stenosis by overdilatation and deendothelialization and compare the model in normocholesterolemic versus hypercholesterolemic rabbits.
METHODS.Thirty male New Zealand White rabbits were randomized into two groupsgroup A (n = 15) was fed a normal diet and group B (n = 15) was fed a cholesterol-rich diet 4 weeks before stenosis induction. An aortogram was performed, then the right renal artery was overdilated with an angioplasty balloon-catheter, and deendothelialized. After 6 weeks, groups A and B were compared by angiographic and pathologic study.
RESULTS.Comparison of group A versus group B showed that 12 arteries (80%) versus 6 (40%) were angiographically stenotic (P < 0.05); 14 (93%) versus 12 (80%) contained neointima (NS), 12 (80%) versus 3 (20%) showed medial disorganization (P < 0.01), and 9 (60%) versus 2 (13%) presented adventitial fibrosis (P < 0.01).
CONCLUSIONS.A new model of endovascularly induced renal artery stenosis has been developed in rabbits. Medial proliferation and adventitial fibrosis are more frequent in normocholesterolemic rabbits. |
| doi_str_mv | 10.1097/00004424-199806000-00002 |
| format | Article |
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METHODS.Thirty male New Zealand White rabbits were randomized into two groupsgroup A (n = 15) was fed a normal diet and group B (n = 15) was fed a cholesterol-rich diet 4 weeks before stenosis induction. An aortogram was performed, then the right renal artery was overdilated with an angioplasty balloon-catheter, and deendothelialized. After 6 weeks, groups A and B were compared by angiographic and pathologic study.
RESULTS.Comparison of group A versus group B showed that 12 arteries (80%) versus 6 (40%) were angiographically stenotic (P < 0.05); 14 (93%) versus 12 (80%) contained neointima (NS), 12 (80%) versus 3 (20%) showed medial disorganization (P < 0.01), and 9 (60%) versus 2 (13%) presented adventitial fibrosis (P < 0.01).
CONCLUSIONS.A new model of endovascularly induced renal artery stenosis has been developed in rabbits. Medial proliferation and adventitial fibrosis are more frequent in normocholesterolemic rabbits.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-199806000-00002</identifier><identifier>PMID: 9647443</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Angiography ; Angioplasty, Balloon ; Animals ; Chi-Square Distribution ; Disease Models, Animal ; Endothelium, Vascular - injuries ; Endothelium, Vascular - pathology ; Feasibility Studies ; Hypercholesterolemia ; Male ; Pilot Projects ; Rabbits ; Renal Artery - injuries ; Renal Artery - pathology ; Renal Artery Obstruction - diagnostic imaging ; Renal Artery Obstruction - pathology</subject><ispartof>Investigative radiology, 1998-06, Vol.33 (6), p.322-328</ispartof><rights>Lippincott-Raven Publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3552-be2769499c3bc4d2b7a9269ca8693692a0c7d138c351782b0d9c2782bb4055063</citedby><cites>FETCH-LOGICAL-c3552-be2769499c3bc4d2b7a9269ca8693692a0c7d138c351782b0d9c2782bb4055063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9647443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LE BLANCHE, ALAIN-FERDINAND</creatorcontrib><creatorcontrib>SIBONY, MATHILDE</creatorcontrib><creatorcontrib>KOLLAR, ATTILA</creatorcontrib><creatorcontrib>CALLARD, PATRICE</creatorcontrib><creatorcontrib>BIGOT, JEAN-MICHEL</creatorcontrib><creatorcontrib>BOUDGHENE, FRANK</creatorcontrib><title>A New Model of Endovascularly Induced Renal Artery Stenosis in Normocholesterolemic Versus Hypercholesterolemic Rabbits</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>RATIONALE AND OBJECTIVES.The authors determine the feasibility of creating renal artery stenosis by overdilatation and deendothelialization and compare the model in normocholesterolemic versus hypercholesterolemic rabbits.
METHODS.Thirty male New Zealand White rabbits were randomized into two groupsgroup A (n = 15) was fed a normal diet and group B (n = 15) was fed a cholesterol-rich diet 4 weeks before stenosis induction. An aortogram was performed, then the right renal artery was overdilated with an angioplasty balloon-catheter, and deendothelialized. After 6 weeks, groups A and B were compared by angiographic and pathologic study.
RESULTS.Comparison of group A versus group B showed that 12 arteries (80%) versus 6 (40%) were angiographically stenotic (P < 0.05); 14 (93%) versus 12 (80%) contained neointima (NS), 12 (80%) versus 3 (20%) showed medial disorganization (P < 0.01), and 9 (60%) versus 2 (13%) presented adventitial fibrosis (P < 0.01).
CONCLUSIONS.A new model of endovascularly induced renal artery stenosis has been developed in rabbits. Medial proliferation and adventitial fibrosis are more frequent in normocholesterolemic rabbits.</description><subject>Angiography</subject><subject>Angioplasty, Balloon</subject><subject>Animals</subject><subject>Chi-Square Distribution</subject><subject>Disease Models, Animal</subject><subject>Endothelium, Vascular - injuries</subject><subject>Endothelium, Vascular - pathology</subject><subject>Feasibility Studies</subject><subject>Hypercholesterolemia</subject><subject>Male</subject><subject>Pilot Projects</subject><subject>Rabbits</subject><subject>Renal Artery - injuries</subject><subject>Renal Artery - pathology</subject><subject>Renal Artery Obstruction - diagnostic imaging</subject><subject>Renal Artery Obstruction - pathology</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtPGzEUha2qCFLan1DJK3ZD_Rp77jJCtCBRKvHo1vJ4bpQpnnGwM43y73GawAKp3lz7nHOvrc-EUM7OOQPzjZWllFAVB2iYLqdqJ4kPZMZrqSsmOPtIZkVhFQDoE_Ip5z-7hGHymByDVkYpOSObOb3FDf0ZOww0Lujl2MW_LvspuBS29HrsJo8dvcPRBTpPa0xber_GMeY-036ktzEN0S9jwFy8Uobe09-Y8pTp1XaF6b1359q2X-fP5GjhQsYvh3pKHr9fPlxcVTe_flxfzG8qL-taVC0Ko0EBeNl61YnWOBAavGs0SA3CMW86LpuS5qYRLevAi92mVayumZan5Gw_d5Xi81QeYoc-ewzBjRinbA2A4byRJdjsgz7FnBMu7Cr1g0tby5ndMbevzO0b83-SKK1fD3dM7YDdW-MBcvHV3t_EUEDkpzBtMNklurBe2v99pXwB8wOM8A</recordid><startdate>199806</startdate><enddate>199806</enddate><creator>LE BLANCHE, ALAIN-FERDINAND</creator><creator>SIBONY, MATHILDE</creator><creator>KOLLAR, ATTILA</creator><creator>CALLARD, PATRICE</creator><creator>BIGOT, JEAN-MICHEL</creator><creator>BOUDGHENE, FRANK</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199806</creationdate><title>A New Model of Endovascularly Induced Renal Artery Stenosis in Normocholesterolemic Versus Hypercholesterolemic Rabbits</title><author>LE BLANCHE, ALAIN-FERDINAND ; SIBONY, MATHILDE ; KOLLAR, ATTILA ; CALLARD, PATRICE ; BIGOT, JEAN-MICHEL ; BOUDGHENE, FRANK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3552-be2769499c3bc4d2b7a9269ca8693692a0c7d138c351782b0d9c2782bb4055063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Angiography</topic><topic>Angioplasty, Balloon</topic><topic>Animals</topic><topic>Chi-Square Distribution</topic><topic>Disease Models, Animal</topic><topic>Endothelium, Vascular - injuries</topic><topic>Endothelium, Vascular - pathology</topic><topic>Feasibility Studies</topic><topic>Hypercholesterolemia</topic><topic>Male</topic><topic>Pilot Projects</topic><topic>Rabbits</topic><topic>Renal Artery - injuries</topic><topic>Renal Artery - pathology</topic><topic>Renal Artery Obstruction - diagnostic imaging</topic><topic>Renal Artery Obstruction - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LE BLANCHE, ALAIN-FERDINAND</creatorcontrib><creatorcontrib>SIBONY, MATHILDE</creatorcontrib><creatorcontrib>KOLLAR, ATTILA</creatorcontrib><creatorcontrib>CALLARD, PATRICE</creatorcontrib><creatorcontrib>BIGOT, JEAN-MICHEL</creatorcontrib><creatorcontrib>BOUDGHENE, FRANK</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LE BLANCHE, ALAIN-FERDINAND</au><au>SIBONY, MATHILDE</au><au>KOLLAR, ATTILA</au><au>CALLARD, PATRICE</au><au>BIGOT, JEAN-MICHEL</au><au>BOUDGHENE, FRANK</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Model of Endovascularly Induced Renal Artery Stenosis in Normocholesterolemic Versus Hypercholesterolemic Rabbits</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1998-06</date><risdate>1998</risdate><volume>33</volume><issue>6</issue><spage>322</spage><epage>328</epage><pages>322-328</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>RATIONALE AND OBJECTIVES.The authors determine the feasibility of creating renal artery stenosis by overdilatation and deendothelialization and compare the model in normocholesterolemic versus hypercholesterolemic rabbits.
METHODS.Thirty male New Zealand White rabbits were randomized into two groupsgroup A (n = 15) was fed a normal diet and group B (n = 15) was fed a cholesterol-rich diet 4 weeks before stenosis induction. An aortogram was performed, then the right renal artery was overdilated with an angioplasty balloon-catheter, and deendothelialized. After 6 weeks, groups A and B were compared by angiographic and pathologic study.
RESULTS.Comparison of group A versus group B showed that 12 arteries (80%) versus 6 (40%) were angiographically stenotic (P < 0.05); 14 (93%) versus 12 (80%) contained neointima (NS), 12 (80%) versus 3 (20%) showed medial disorganization (P < 0.01), and 9 (60%) versus 2 (13%) presented adventitial fibrosis (P < 0.01).
CONCLUSIONS.A new model of endovascularly induced renal artery stenosis has been developed in rabbits. Medial proliferation and adventitial fibrosis are more frequent in normocholesterolemic rabbits.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>9647443</pmid><doi>10.1097/00004424-199806000-00002</doi><tpages>7</tpages></addata></record> |
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| ispartof | Investigative radiology, 1998-06, Vol.33 (6), p.322-328 |
| issn | 0020-9996 1536-0210 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Angiography Angioplasty, Balloon Animals Chi-Square Distribution Disease Models, Animal Endothelium, Vascular - injuries Endothelium, Vascular - pathology Feasibility Studies Hypercholesterolemia Male Pilot Projects Rabbits Renal Artery - injuries Renal Artery - pathology Renal Artery Obstruction - diagnostic imaging Renal Artery Obstruction - pathology |
| title | A New Model of Endovascularly Induced Renal Artery Stenosis in Normocholesterolemic Versus Hypercholesterolemic Rabbits |
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