Superior Hydrodynamics of a Modified Cavopulmonary Connection for the Norwood Operation
Background. In the Fontan circulation, energy consumption at the cavopulmonary connection is crucial. Our hypothesis was that a modification of the standard Norwood variant of cavopulmonary connection with an extended anastomosis would improve hydrodynamics. Methods. The in vitro hydrodynamics of tw...
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Veröffentlicht in: | The Annals of thoracic surgery 1998-06, Vol.65 (6), p.1741-1745 |
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description | Background. In the Fontan circulation, energy consumption at the cavopulmonary connection is crucial. Our hypothesis was that a modification of the standard Norwood variant of cavopulmonary connection with an extended anastomosis would improve hydrodynamics.
Methods. The in vitro hydrodynamics of two different Perspex glass models resembling the Norwood variant of cavopulmonary connection (model I) and the modification (model II) were analyzed in a mock circulation at nonpulsatile flows of 2 to 5 L/min to simulate rest and exercise. The pulmonary flow split was varied to imitate varying lung resistances. Inferior-to-superior caval flow ratio and size of models were increased to simulate growth.
Results. The pulmonary flow was preferentially directed to the left lung in model I and was better balanced in model II. Power losses increased exponentially with total flow in both models and were markedly higher in model I. These differences were attenuated in the larger models. Anastomotic turbulences were larger in model I. Power losses in both models were relatively insensitive to changes in pulmonary flow split.
Conclusions. The proposed modification of the Norwood variant of cavopulmonary connection seems to be hydrodynamically advantageous and warrants further evaluation. |
doi_str_mv | 10.1016/S0003-4975(98)00252-5 |
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Methods. The in vitro hydrodynamics of two different Perspex glass models resembling the Norwood variant of cavopulmonary connection (model I) and the modification (model II) were analyzed in a mock circulation at nonpulsatile flows of 2 to 5 L/min to simulate rest and exercise. The pulmonary flow split was varied to imitate varying lung resistances. Inferior-to-superior caval flow ratio and size of models were increased to simulate growth.
Results. The pulmonary flow was preferentially directed to the left lung in model I and was better balanced in model II. Power losses increased exponentially with total flow in both models and were markedly higher in model I. These differences were attenuated in the larger models. Anastomotic turbulences were larger in model I. Power losses in both models were relatively insensitive to changes in pulmonary flow split.
Conclusions. The proposed modification of the Norwood variant of cavopulmonary connection seems to be hydrodynamically advantageous and warrants further evaluation.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(98)00252-5</identifier><identifier>PMID: 9647092</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anastomosis, Surgical - methods ; Biological and medical sciences ; Energy Metabolism ; Fontan Procedure ; Hemorheology ; Humans ; Hypoplastic Left Heart Syndrome - physiopathology ; Hypoplastic Left Heart Syndrome - surgery ; Medical sciences ; Models, Anatomic ; Models, Cardiovascular ; Physical Exertion - physiology ; Polymethyl Methacrylate ; Pulmonary Artery - growth & development ; Pulmonary Artery - surgery ; Pulmonary Circulation - physiology ; Regional Blood Flow - physiology ; Rest - physiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Vascular Resistance - physiology ; Vena Cava, Inferior - physiology ; Vena Cava, Superior - growth & development ; Vena Cava, Superior - surgery</subject><ispartof>The Annals of thoracic surgery, 1998-06, Vol.65 (6), p.1741-1745</ispartof><rights>1998 by The Society of Thoracic Surgeons</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-b4472cbc7f5b8c2ad89a14e48b8f40b8f2611a694db5d41fcf3a8933d6770abf3</citedby><cites>FETCH-LOGICAL-c472t-b4472cbc7f5b8c2ad89a14e48b8f40b8f2611a694db5d41fcf3a8933d6770abf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0003-4975(98)00252-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2294835$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9647092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sievers, Hans-Hinrich</creatorcontrib><creatorcontrib>Gerdes, Anja</creatorcontrib><creatorcontrib>Kunze, Jörg</creatorcontrib><creatorcontrib>Pfister, Gerd</creatorcontrib><title>Superior Hydrodynamics of a Modified Cavopulmonary Connection for the Norwood Operation</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background. In the Fontan circulation, energy consumption at the cavopulmonary connection is crucial. Our hypothesis was that a modification of the standard Norwood variant of cavopulmonary connection with an extended anastomosis would improve hydrodynamics.
Methods. The in vitro hydrodynamics of two different Perspex glass models resembling the Norwood variant of cavopulmonary connection (model I) and the modification (model II) were analyzed in a mock circulation at nonpulsatile flows of 2 to 5 L/min to simulate rest and exercise. The pulmonary flow split was varied to imitate varying lung resistances. Inferior-to-superior caval flow ratio and size of models were increased to simulate growth.
Results. The pulmonary flow was preferentially directed to the left lung in model I and was better balanced in model II. Power losses increased exponentially with total flow in both models and were markedly higher in model I. These differences were attenuated in the larger models. Anastomotic turbulences were larger in model I. Power losses in both models were relatively insensitive to changes in pulmonary flow split.
Conclusions. The proposed modification of the Norwood variant of cavopulmonary connection seems to be hydrodynamically advantageous and warrants further evaluation.</description><subject>Anastomosis, Surgical - methods</subject><subject>Biological and medical sciences</subject><subject>Energy Metabolism</subject><subject>Fontan Procedure</subject><subject>Hemorheology</subject><subject>Humans</subject><subject>Hypoplastic Left Heart Syndrome - physiopathology</subject><subject>Hypoplastic Left Heart Syndrome - surgery</subject><subject>Medical sciences</subject><subject>Models, Anatomic</subject><subject>Models, Cardiovascular</subject><subject>Physical Exertion - physiology</subject><subject>Polymethyl Methacrylate</subject><subject>Pulmonary Artery - growth & development</subject><subject>Pulmonary Artery - surgery</subject><subject>Pulmonary Circulation - physiology</subject><subject>Regional Blood Flow - physiology</subject><subject>Rest - physiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Vascular Resistance - physiology</subject><subject>Vena Cava, Inferior - physiology</subject><subject>Vena Cava, Superior - growth & development</subject><subject>Vena Cava, Superior - surgery</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtPwyAcx4nR6Hz8CSYcjNFDFSi05WTMos5kuoMaj4TyiJi2TGhn9t_LHtnVCz_I9wF8ADjH6AYjXNy-IYTyjPKSXfHqGiHCSMb2wAiztCkI4_tgtLMcgeMYv9ORJPkQHPKCloiTEfh8G-YmOB_gZKmD18tOtk5F6C2U8MVrZ53RcCwXfj40re9kWMKx7zqjeuc7aFOw_zLw1Ydf7zWcpTK5Uk7BgZVNNGfbeQI-Hh_ex5NsOnt6Ht9PM0VL0mc1TUPVqrSsrhSRuuISU0OrurIUpYUUGMuCU10zTbFVNpcVz3NdlCWStc1PwOWmdx78z2BiL1oXlWka2Rk_RFFyXmLEi2RkG6MKPsZgrJgH16bvCIzECqhYAxUrWoJXYg1UsJQ7314w1K3Ru9SWYNIvtrqMSjY2yE65uLMRwmmVr2ruNjaTYCycCSIqZzpltAuJpdDe_fOQP787kyc</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Sievers, Hans-Hinrich</creator><creator>Gerdes, Anja</creator><creator>Kunze, Jörg</creator><creator>Pfister, Gerd</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Superior Hydrodynamics of a Modified Cavopulmonary Connection for the Norwood Operation</title><author>Sievers, Hans-Hinrich ; Gerdes, Anja ; Kunze, Jörg ; Pfister, Gerd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-b4472cbc7f5b8c2ad89a14e48b8f40b8f2611a694db5d41fcf3a8933d6770abf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anastomosis, Surgical - methods</topic><topic>Biological and medical sciences</topic><topic>Energy Metabolism</topic><topic>Fontan Procedure</topic><topic>Hemorheology</topic><topic>Humans</topic><topic>Hypoplastic Left Heart Syndrome - physiopathology</topic><topic>Hypoplastic Left Heart Syndrome - surgery</topic><topic>Medical sciences</topic><topic>Models, Anatomic</topic><topic>Models, Cardiovascular</topic><topic>Physical Exertion - physiology</topic><topic>Polymethyl Methacrylate</topic><topic>Pulmonary Artery - growth & development</topic><topic>Pulmonary Artery - surgery</topic><topic>Pulmonary Circulation - physiology</topic><topic>Regional Blood Flow - physiology</topic><topic>Rest - physiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Vascular Resistance - physiology</topic><topic>Vena Cava, Inferior - physiology</topic><topic>Vena Cava, Superior - growth & development</topic><topic>Vena Cava, Superior - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sievers, Hans-Hinrich</creatorcontrib><creatorcontrib>Gerdes, Anja</creatorcontrib><creatorcontrib>Kunze, Jörg</creatorcontrib><creatorcontrib>Pfister, Gerd</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sievers, Hans-Hinrich</au><au>Gerdes, Anja</au><au>Kunze, Jörg</au><au>Pfister, Gerd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superior Hydrodynamics of a Modified Cavopulmonary Connection for the Norwood Operation</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>65</volume><issue>6</issue><spage>1741</spage><epage>1745</epage><pages>1741-1745</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>Background. In the Fontan circulation, energy consumption at the cavopulmonary connection is crucial. Our hypothesis was that a modification of the standard Norwood variant of cavopulmonary connection with an extended anastomosis would improve hydrodynamics.
Methods. The in vitro hydrodynamics of two different Perspex glass models resembling the Norwood variant of cavopulmonary connection (model I) and the modification (model II) were analyzed in a mock circulation at nonpulsatile flows of 2 to 5 L/min to simulate rest and exercise. The pulmonary flow split was varied to imitate varying lung resistances. Inferior-to-superior caval flow ratio and size of models were increased to simulate growth.
Results. The pulmonary flow was preferentially directed to the left lung in model I and was better balanced in model II. Power losses increased exponentially with total flow in both models and were markedly higher in model I. These differences were attenuated in the larger models. Anastomotic turbulences were larger in model I. Power losses in both models were relatively insensitive to changes in pulmonary flow split.
Conclusions. The proposed modification of the Norwood variant of cavopulmonary connection seems to be hydrodynamically advantageous and warrants further evaluation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9647092</pmid><doi>10.1016/S0003-4975(98)00252-5</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Anastomosis, Surgical - methods Biological and medical sciences Energy Metabolism Fontan Procedure Hemorheology Humans Hypoplastic Left Heart Syndrome - physiopathology Hypoplastic Left Heart Syndrome - surgery Medical sciences Models, Anatomic Models, Cardiovascular Physical Exertion - physiology Polymethyl Methacrylate Pulmonary Artery - growth & development Pulmonary Artery - surgery Pulmonary Circulation - physiology Regional Blood Flow - physiology Rest - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Vascular Resistance - physiology Vena Cava, Inferior - physiology Vena Cava, Superior - growth & development Vena Cava, Superior - surgery |
title | Superior Hydrodynamics of a Modified Cavopulmonary Connection for the Norwood Operation |
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