High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults
To examine extra-alimentary effects of high-carbohydrate, high-fiber (HCF) diets, insulin-mediated glucose disposal employing the euglycemic clamp and hepatic glucose output (HGO) employing [6,6-2H2]glucose were measured in 12 healthy young and old individuals before and after 21–28 d of an HCF diet...
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| Veröffentlicht in: | The American journal of clinical nutrition 1990-09, Vol.52 (3), p.524-528 |
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| creator | Fukagawa, NK Anderson, JW Hageman, G Young, VR Minaker, KL |
| description | To examine extra-alimentary effects of high-carbohydrate, high-fiber (HCF) diets, insulin-mediated glucose disposal employing the euglycemic clamp and hepatic glucose output (HGO) employing [6,6-2H2]glucose were measured in 12 healthy young and old individuals before and after 21–28 d of an HCF diet. Diet lowered fasting concentrations of glucose from 5.3 ± 0.2 to 5.1 ± 0.1 mmol/L (p less than 0.01) and insulin from 66.0 ± 7.9 to 49.5 ± 5.7 pmol/L (p less than 0.01). Fasting serum cholesterol decreased from 5.17 ± 0.18 to 3.80 ± 0.20 mmol/L (p less than 0.01) in young individuals and from 6.15 ± 0.52 to 4.99 ± 0.49 mmol/L (p less than 0.01) in elderly individuals. Fasting serum triglyceride concentrations, basal HGO, and insulin suppression of HGO were unchanged by the diet. Glucose disposal rates increased from 18.87 ± 1.66 before 23.87 ± 2.78 mumol.kg−1.min−1 after the diet (p less than 0.02). Therefore, HCF diets may improve carbohydrate economy by enhanced peripheral sensitivity to insulin. |
| doi_str_mv | 10.1093/ajcn/52.3.524 |
| format | Article |
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Diet lowered fasting concentrations of glucose from 5.3 ± 0.2 to 5.1 ± 0.1 mmol/L (p less than 0.01) and insulin from 66.0 ± 7.9 to 49.5 ± 5.7 pmol/L (p less than 0.01). Fasting serum cholesterol decreased from 5.17 ± 0.18 to 3.80 ± 0.20 mmol/L (p less than 0.01) in young individuals and from 6.15 ± 0.52 to 4.99 ± 0.49 mmol/L (p less than 0.01) in elderly individuals. Fasting serum triglyceride concentrations, basal HGO, and insulin suppression of HGO were unchanged by the diet. Glucose disposal rates increased from 18.87 ± 1.66 before 23.87 ± 2.78 mumol.kg−1.min−1 after the diet (p less than 0.02). 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Diet lowered fasting concentrations of glucose from 5.3 ± 0.2 to 5.1 ± 0.1 mmol/L (p less than 0.01) and insulin from 66.0 ± 7.9 to 49.5 ± 5.7 pmol/L (p less than 0.01). Fasting serum cholesterol decreased from 5.17 ± 0.18 to 3.80 ± 0.20 mmol/L (p less than 0.01) in young individuals and from 6.15 ± 0.52 to 4.99 ± 0.49 mmol/L (p less than 0.01) in elderly individuals. Fasting serum triglyceride concentrations, basal HGO, and insulin suppression of HGO were unchanged by the diet. Glucose disposal rates increased from 18.87 ± 1.66 before 23.87 ± 2.78 mumol.kg−1.min−1 after the diet (p less than 0.02). Therefore, HCF diets may improve carbohydrate economy by enhanced peripheral sensitivity to insulin.</description><subject>Adult</subject><subject>ADULTE</subject><subject>ADULTOS</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - metabolism</subject><subject>Biological and medical sciences</subject><subject>CARBOHIDRATOS</subject><subject>Carbohydrates</subject><subject>CHOLESTEROL</subject><subject>Cholesterol - metabolism</subject><subject>COLESTEROL</subject><subject>DIETA</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>Dietary Fiber - pharmacology</subject><subject>Energy Intake - physiology</subject><subject>Fasting - metabolism</subject><subject>Female</subject><subject>FEMME</subject><subject>FIBRA DE LA DIETA</subject><subject>FIBRE ALIMENTAIRE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLICEMIA</subject><subject>GLUCIDE</subject><subject>Glucose - administration & dosage</subject><subject>Glucose - metabolism</subject><subject>Glucose Clamp Technique</subject><subject>GLYCEMIE</subject><subject>HOMBRES</subject><subject>HOMME</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>INSULINA</subject><subject>INSULINE</subject><subject>LIPEMIA</subject><subject>LIPEMIE</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>MUJERES</subject><subject>PERSONNE AGEE</subject><subject>REGIME ALIMENTAIRE</subject><subject>TERCERA EDAD</subject><subject>TRIGLICERIDOS</subject><subject>TRIGLYCERIDE</subject><subject>Triglycerides - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1v1DAQxS0EKtvCkQsSki9wIlt_JY6PVQUtUiUO0LM1sScbl2yy2E6l_Pd4tSs4cZkZvffT0-gR8o6zLWdGXsOTm65rsZXbWqgXZMONbCspmH5JNowxURne1K_JZUpPjHGh2uaCXAjetOXekF_3YTdUDmI3D6uPkPEzHY5SHzqM1AfMiYbJRYSE9IAxHAaMMBYtLWOYaMIphRyeQ16LRgeEMQ8rXedl2lGYPJ1HT8EvY05vyKsexoRvz_uKPH798vP2vnr4fvft9uahcsqwXPXatU476TuhvZZMOt5L3XDdS9EKpxotdYudkSABOudV0wByhV55rpnq5RX5dMo9xPn3ginbfUgOxxEmnJdktTGaM9EWsDqBLs4pReztIYY9xNVyZo_l2mO5thZWlqEK_-EcvHR79H_pc5vF_3j2ITkY-wiTC-lfqGmlUvWRe3_iepgt7GJhHn8YznnTmGLqk4mloueA0SYXcHLoQ0SXrZ_Df977A4w9n2w</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Fukagawa, NK</creator><creator>Anderson, JW</creator><creator>Hageman, G</creator><creator>Young, VR</creator><creator>Minaker, KL</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults</title><author>Fukagawa, NK ; Anderson, JW ; Hageman, G ; Young, VR ; Minaker, KL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-f7c8c7c3db27d7303c1f37617f3282c467378eb93a3aabcd466ae14ed4d1704f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>ADULTE</topic><topic>ADULTOS</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - metabolism</topic><topic>Biological and medical sciences</topic><topic>CARBOHIDRATOS</topic><topic>Carbohydrates</topic><topic>CHOLESTEROL</topic><topic>Cholesterol - metabolism</topic><topic>COLESTEROL</topic><topic>DIETA</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>Dietary Fiber - pharmacology</topic><topic>Energy Intake - physiology</topic><topic>Fasting - metabolism</topic><topic>Female</topic><topic>FEMME</topic><topic>FIBRA DE LA DIETA</topic><topic>FIBRE ALIMENTAIRE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLICEMIA</topic><topic>GLUCIDE</topic><topic>Glucose - administration & dosage</topic><topic>Glucose - metabolism</topic><topic>Glucose Clamp Technique</topic><topic>GLYCEMIE</topic><topic>HOMBRES</topic><topic>HOMME</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>INSULINA</topic><topic>INSULINE</topic><topic>LIPEMIA</topic><topic>LIPEMIE</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>MUJERES</topic><topic>PERSONNE AGEE</topic><topic>REGIME ALIMENTAIRE</topic><topic>TERCERA EDAD</topic><topic>TRIGLICERIDOS</topic><topic>TRIGLYCERIDE</topic><topic>Triglycerides - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukagawa, NK</creatorcontrib><creatorcontrib>Anderson, JW</creatorcontrib><creatorcontrib>Hageman, G</creatorcontrib><creatorcontrib>Young, VR</creatorcontrib><creatorcontrib>Minaker, KL</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukagawa, NK</au><au>Anderson, JW</au><au>Hageman, G</au><au>Young, VR</au><au>Minaker, KL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>52</volume><issue>3</issue><spage>524</spage><epage>528</epage><pages>524-528</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>To examine extra-alimentary effects of high-carbohydrate, high-fiber (HCF) diets, insulin-mediated glucose disposal employing the euglycemic clamp and hepatic glucose output (HGO) employing [6,6-2H2]glucose were measured in 12 healthy young and old individuals before and after 21–28 d of an HCF diet. Diet lowered fasting concentrations of glucose from 5.3 ± 0.2 to 5.1 ± 0.1 mmol/L (p less than 0.01) and insulin from 66.0 ± 7.9 to 49.5 ± 5.7 pmol/L (p less than 0.01). Fasting serum cholesterol decreased from 5.17 ± 0.18 to 3.80 ± 0.20 mmol/L (p less than 0.01) in young individuals and from 6.15 ± 0.52 to 4.99 ± 0.49 mmol/L (p less than 0.01) in elderly individuals. Fasting serum triglyceride concentrations, basal HGO, and insulin suppression of HGO were unchanged by the diet. Glucose disposal rates increased from 18.87 ± 1.66 before 23.87 ± 2.78 mumol.kg−1.min−1 after the diet (p less than 0.02). Therefore, HCF diets may improve carbohydrate economy by enhanced peripheral sensitivity to insulin.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2168124</pmid><doi>10.1093/ajcn/52.3.524</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult ADULTE ADULTOS Aged Aged, 80 and over Aging - metabolism Biological and medical sciences CARBOHIDRATOS Carbohydrates CHOLESTEROL Cholesterol - metabolism COLESTEROL DIETA Dietary Carbohydrates - pharmacology Dietary Fiber - pharmacology Energy Intake - physiology Fasting - metabolism Female FEMME FIBRA DE LA DIETA FIBRE ALIMENTAIRE Fundamental and applied biological sciences. Psychology GLICEMIA GLUCIDE Glucose - administration & dosage Glucose - metabolism Glucose Clamp Technique GLYCEMIE HOMBRES HOMME Humans Insulin - metabolism INSULINA INSULINE LIPEMIA LIPEMIE Male Metabolisms and neurohumoral controls MUJERES PERSONNE AGEE REGIME ALIMENTAIRE TERCERA EDAD TRIGLICERIDOS TRIGLYCERIDE Triglycerides - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults |
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