Odorants Selectively Activate Distinct G Protein Subtypes in Olfactory Cilia

Chemoelectrical signal transduction in olfactory neurons appears to involve intracellular reaction cascades mediated by heterotrimeric GTP-binding proteins. In this study attempts were made to identify the G protein subtype(s) in olfactory cilia that are activated by the primary (odorant) signal. An...

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Veröffentlicht in:	The Journal of biological chemistry 1998-07, Vol.273 (27), p.16669-16677
Hauptverfasser:	Schandar, M, Laugwitz, K L, Boekhoff, I, Kroner, C, Gudermann, T, Schultz, G, Breer, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Aldehydes - pharmacology Amino Acid Sequence Animals Benzaldehydes - pharmacology Cilia - drug effects Cilia - metabolism Cyclic AMP - biosynthesis Cyclohexenes Cyclopentanes - pharmacology Eugenol - pharmacology GTP-Binding Proteins - metabolism Inositol 1,4,5-Trisphosphate - biosynthesis Molecular Sequence Data Nitriles - pharmacology Odorants Olfactory Mucosa - drug effects Olfactory Mucosa - metabolism Oxylipins Photoaffinity Labels Rats Rats, Sprague-Dawley Signal Transduction - drug effects
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