Antibacterials. Synthesis and structure-activity studies of 3-aryl-2-oxooxazolidines. 2. The "A" group

The synthesis and structure-activity relationship (SAR) studies of the effect of varying the "A" group in a series of 5-(acetamidomethyl)oxazolidonone antibacterials (2) are described. Compounds 2 were principally prepared either by the six-step synthesis described previously (J. Med. Chem...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-09, Vol.33 (9), p.2569-2578
Hauptverfasser:	Gregory, Walter A, Brittelli, David R, Wang, C. L. J, Kezar, Hollis S, Carlson, Randall K, Park, Chung Ho, Corless, Peter F, Miller, Steven J, Rajagopalan, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Chemical Phenomena Chemistry Enterococcus faecalis Enterococcus faecalis - drug effects Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Microbial Sensitivity Tests Organic chemistry Oxazoles - chemical synthesis Oxazoles - pharmacology Preparations and properties Staphylococcus aureus - drug effects Structure-Activity Relationship
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