Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix
Abstract Traditionally in Japan, some kampo medicines (traditional oriental herbal prescriptions) have long been used for the treatment of diabetic neuropathy. We have found that some aldose reductase inhibitors are included among these drugs. We further investigated the components of glycyrrhizae r...
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| Veröffentlicht in: | Planta medica 1990-06, Vol.56 (3), p.254-258 |
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| creator | Aida, K Tawata, M Shindo, H Onaya, T Sasaki, H Yamaguchi, T Chin, M Mitsuhashi, H |
| description | Abstract
Traditionally in Japan, some kampo medicines (traditional oriental herbal prescriptions) have long been used for the treatment of diabetic neuropathy. We have found that some aldose reductase inhibitors are included among these drugs. We further investigated the components of glycyrrhizae radix, a constituent of some kampo medicines, and isolated six compounds (GUs 9-17). Among these, GU-17, identified as isoliquiritigenin, had the most potent aldose reductase inhibiting activity. Isoliquiritigenin inhibited rat lens aldose reductase with an IC
50
of 3.2 × 10
-7
M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells IN VITRO, with an IC
50
of 2.0 × 10
-6
M. Isoliquiritigenin, when administered via an intragastric tube to diabetic rats, suppressed sorbitol accumulation in the red blood cells, the sciatic nerve, and the lens as effectively as ONO-2235. These results suggest that isoliquiritigenin may be effective in preventing diabetic complications. |
| doi_str_mv | 10.1055/s-2006-960950 |
| format | Article |
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Traditionally in Japan, some kampo medicines (traditional oriental herbal prescriptions) have long been used for the treatment of diabetic neuropathy. We have found that some aldose reductase inhibitors are included among these drugs. We further investigated the components of glycyrrhizae radix, a constituent of some kampo medicines, and isolated six compounds (GUs 9-17). Among these, GU-17, identified as isoliquiritigenin, had the most potent aldose reductase inhibiting activity. Isoliquiritigenin inhibited rat lens aldose reductase with an IC
50
of 3.2 × 10
-7
M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells IN VITRO, with an IC
50
of 2.0 × 10
-6
M. Isoliquiritigenin, when administered via an intragastric tube to diabetic rats, suppressed sorbitol accumulation in the red blood cells, the sciatic nerve, and the lens as effectively as ONO-2235. These results suggest that isoliquiritigenin may be effective in preventing diabetic complications.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-960950</identifier><identifier>PMID: 2118267</identifier><language>eng</language><publisher>Germany</publisher><subject><![CDATA[Aldehyde Reductase - antagonists & inhibitors ; aldose reductase activity ; aldoses ; Animals ; Chalcone - analogs & derivatives ; Chalcone - isolation & purification ; Chalcone - pharmacology ; Chalcones ; diabetes ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Drugs, Chinese Herbal - isolation & purification ; Drugs, Chinese Herbal - pharmacology ; Erythrocytes - drug effects ; Erythrocytes - metabolism ; Glycyrrhiza uralensis ; Humans ; inhibitors ; Male ; medicinal plants ; Molecular Structure ; plant extracts ; Plants, Medicinal - chemistry ; Propiophenones - isolation & purification ; Rats ; Rats, Inbred Strains ; sorbitol ; Sorbitol - metabolism ; Sugar Alcohol Dehydrogenases - antagonists & inhibitors]]></subject><ispartof>Planta medica, 1990-06, Vol.56 (3), p.254-258</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-8788fe7a8ef5f6a50204d4fc0f5c46fc532f1d2ef16a06c7a452abe8b4336c553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-960950.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3003,3004,27903,27904,54538</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2118267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aida, K</creatorcontrib><creatorcontrib>Tawata, M</creatorcontrib><creatorcontrib>Shindo, H</creatorcontrib><creatorcontrib>Onaya, T</creatorcontrib><creatorcontrib>Sasaki, H</creatorcontrib><creatorcontrib>Yamaguchi, T</creatorcontrib><creatorcontrib>Chin, M</creatorcontrib><creatorcontrib>Mitsuhashi, H</creatorcontrib><title>Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Traditionally in Japan, some kampo medicines (traditional oriental herbal prescriptions) have long been used for the treatment of diabetic neuropathy. We have found that some aldose reductase inhibitors are included among these drugs. We further investigated the components of glycyrrhizae radix, a constituent of some kampo medicines, and isolated six compounds (GUs 9-17). Among these, GU-17, identified as isoliquiritigenin, had the most potent aldose reductase inhibiting activity. Isoliquiritigenin inhibited rat lens aldose reductase with an IC
50
of 3.2 × 10
-7
M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells IN VITRO, with an IC
50
of 2.0 × 10
-6
M. Isoliquiritigenin, when administered via an intragastric tube to diabetic rats, suppressed sorbitol accumulation in the red blood cells, the sciatic nerve, and the lens as effectively as ONO-2235. These results suggest that isoliquiritigenin may be effective in preventing diabetic complications.</description><subject>Aldehyde Reductase - antagonists & inhibitors</subject><subject>aldose reductase activity</subject><subject>aldoses</subject><subject>Animals</subject><subject>Chalcone - analogs & derivatives</subject><subject>Chalcone - isolation & purification</subject><subject>Chalcone - pharmacology</subject><subject>Chalcones</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - metabolism</subject><subject>Glycyrrhiza uralensis</subject><subject>Humans</subject><subject>inhibitors</subject><subject>Male</subject><subject>medicinal plants</subject><subject>Molecular Structure</subject><subject>plant extracts</subject><subject>Plants, Medicinal - chemistry</subject><subject>Propiophenones - isolation & purification</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>sorbitol</subject><subject>Sorbitol - metabolism</subject><subject>Sugar Alcohol Dehydrogenases - antagonists & inhibitors</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EglIYGRGZmAhcPxOzoYqXQGIAZst17NZVEhc7EZRfT1AqNqZ7pPPpSPdD6ATDJQbOr1JOAEQuBUgOO2iCGZU5EIJ30QSAkhwkowfoMKUVAGYSYB_tE4xLIooJenpMofYfvY--8wvb-vY601lrPzNdVyHZLNqqN50ekm-Xfu67EDMXQ5Mt6o3ZxLj033qgdOW_jtCe03Wyx9s7Re93t2-zh_z55f5xdvOcG8pkl5dFWTpb6NI67oTmQIBVzBlw3DDhDKfE4YpYh4UGYQrNONFzW84ZpcJwTqfofNxdx_DR29Spxidj61q3NvRJFVKKkmI8gPkImhhSitapdfSNjhuFQf3KU0n9ylOjvIE_3Q7388ZWf_TW1tBfjH239LaxahX62A6f_jt3NuJOB6UX0Sf1_koAU8AFLWSJ6Q_rBYG1</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>Aida, K</creator><creator>Tawata, M</creator><creator>Shindo, H</creator><creator>Onaya, T</creator><creator>Sasaki, H</creator><creator>Yamaguchi, T</creator><creator>Chin, M</creator><creator>Mitsuhashi, H</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix</title><author>Aida, K ; Tawata, M ; Shindo, H ; Onaya, T ; Sasaki, H ; Yamaguchi, T ; Chin, M ; Mitsuhashi, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-8788fe7a8ef5f6a50204d4fc0f5c46fc532f1d2ef16a06c7a452abe8b4336c553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aldehyde Reductase - antagonists & inhibitors</topic><topic>aldose reductase activity</topic><topic>aldoses</topic><topic>Animals</topic><topic>Chalcone - analogs & derivatives</topic><topic>Chalcone - isolation & purification</topic><topic>Chalcone - pharmacology</topic><topic>Chalcones</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - metabolism</topic><topic>Glycyrrhiza uralensis</topic><topic>Humans</topic><topic>inhibitors</topic><topic>Male</topic><topic>medicinal plants</topic><topic>Molecular Structure</topic><topic>plant extracts</topic><topic>Plants, Medicinal - chemistry</topic><topic>Propiophenones - isolation & purification</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>sorbitol</topic><topic>Sorbitol - metabolism</topic><topic>Sugar Alcohol Dehydrogenases - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aida, K</creatorcontrib><creatorcontrib>Tawata, M</creatorcontrib><creatorcontrib>Shindo, H</creatorcontrib><creatorcontrib>Onaya, T</creatorcontrib><creatorcontrib>Sasaki, H</creatorcontrib><creatorcontrib>Yamaguchi, T</creatorcontrib><creatorcontrib>Chin, M</creatorcontrib><creatorcontrib>Mitsuhashi, H</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aida, K</au><au>Tawata, M</au><au>Shindo, H</au><au>Onaya, T</au><au>Sasaki, H</au><au>Yamaguchi, T</au><au>Chin, M</au><au>Mitsuhashi, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>56</volume><issue>3</issue><spage>254</spage><epage>258</epage><pages>254-258</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><abstract>Abstract
Traditionally in Japan, some kampo medicines (traditional oriental herbal prescriptions) have long been used for the treatment of diabetic neuropathy. We have found that some aldose reductase inhibitors are included among these drugs. We further investigated the components of glycyrrhizae radix, a constituent of some kampo medicines, and isolated six compounds (GUs 9-17). Among these, GU-17, identified as isoliquiritigenin, had the most potent aldose reductase inhibiting activity. Isoliquiritigenin inhibited rat lens aldose reductase with an IC
50
of 3.2 × 10
-7
M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells IN VITRO, with an IC
50
of 2.0 × 10
-6
M. Isoliquiritigenin, when administered via an intragastric tube to diabetic rats, suppressed sorbitol accumulation in the red blood cells, the sciatic nerve, and the lens as effectively as ONO-2235. These results suggest that isoliquiritigenin may be effective in preventing diabetic complications.</abstract><cop>Germany</cop><pmid>2118267</pmid><doi>10.1055/s-2006-960950</doi><tpages>5</tpages></addata></record> |
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| issn | 0032-0943 1439-0221 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Aldehyde Reductase - antagonists & inhibitors aldose reductase activity aldoses Animals Chalcone - analogs & derivatives Chalcone - isolation & purification Chalcone - pharmacology Chalcones diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Erythrocytes - drug effects Erythrocytes - metabolism Glycyrrhiza uralensis Humans inhibitors Male medicinal plants Molecular Structure plant extracts Plants, Medicinal - chemistry Propiophenones - isolation & purification Rats Rats, Inbred Strains sorbitol Sorbitol - metabolism Sugar Alcohol Dehydrogenases - antagonists & inhibitors |
| title | Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix |
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