Role of physiological HCO3-buffer on intracellular pH and histamine release in rat peritoneal mast cells

The purpose of this study was to examine how intracellular pH (pHi) regulation and histamine release are affected by HCO3- in rat peritoneal mast cells. The pHi was measured using the pH-sensitive dye 2', 7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF). We observed a pHi of 6.88+/-0...

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Veröffentlicht in:	Pflügers Archiv 1998-08, Vol.436 (3), p.357-364
Hauptverfasser:	Jensen, T B, Friis, U G, Johansen, T
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology Amiloride - analogs & derivatives Amiloride - pharmacology Animals Antigens - immunology Antiporters - metabolism Bicarbonates - metabolism Biological Transport - drug effects Buffers Carbonic Anhydrase Inhibitors - pharmacology Chloride-Bicarbonate Antiporters Chlorides - metabolism Dichlorphenamide - pharmacology Histamine Histamine - metabolism Hydrogen-Ion Concentration In Vitro Techniques Intracellular Fluid - drug effects Intracellular Fluid - metabolism Male Mast Cells - drug effects Mast Cells - immunology Mast Cells - metabolism p-Methoxy-N-methylphenethylamine - pharmacology Peritoneal Cavity - cytology Rats Rats, Sprague-Dawley Sodium - metabolism
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