Selective Inhibition by Kringle 5 of Human Plasminogen on Endothelial Cell Migration, an Important Process in Angiogenesis

Angiogenesis is a multi-step process that includes endothelial cell proliferation, migration, basement membrane degradation, and new lumen organization. Angiostatin, an internal fragment of plasminogen comprising the first four triple disulfide-linked kringle structures, is one of the most potent en...

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