T2 of endotoxin lung injury with and without methylprednisolone treatment
NMR relaxation times (T1 and T2) and the water content (WC) of in vitro rat lungs were measured during the course of endotoxin lung injury in rats. Measurements of normal lungs, untreated endotoxin‐injured lungs, and endotoxin‐injured lungs treated with methylprednisolone (MPSL) were compared. The u...
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| Veröffentlicht in: | Magnetic resonance in medicine 1990-08, Vol.15 (2), p.201-210 |
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| container_title | Magnetic resonance in medicine |
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| creator | Shioya, Sumie Haida, Munetaka Tsuji, Chizuko Ono, Yoshiaki Miyairi, Akira Fukuzaki, Minoru Ohta, Yasuyo Yamabayashi, Hajime |
| description | NMR relaxation times (T1 and T2) and the water content (WC) of in vitro rat lungs were measured during the course of endotoxin lung injury in rats. Measurements of normal lungs, untreated endotoxin‐injured lungs, and endotoxin‐injured lungs treated with methylprednisolone (MPSL) were compared. The untreated endotoxin lungs showed prolongation of the fast and slow T2 components (T2r and T2s), but no significant changes in T1 or water content. Also, there was no correlation between 1 /WC and relaxation rates or between T1 and T2. MPSL treatment prevented T 2f and T2s prolongation; however, the duration of MPSL effectiveness was limited. Animals which were treated with MPSL more than 7 h prior to measurements showed T2 prolongation. This study indicates that NMR relaxation times, particularly T2, can be useful in evaluating lung injuries and their treatments. © 1990 Academic Press, Inc. |
| doi_str_mv | 10.1002/mrm.1910150204 |
| format | Article |
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Measurements of normal lungs, untreated endotoxin‐injured lungs, and endotoxin‐injured lungs treated with methylprednisolone (MPSL) were compared. The untreated endotoxin lungs showed prolongation of the fast and slow T2 components (T2r and T2s), but no significant changes in T1 or water content. Also, there was no correlation between 1 /WC and relaxation rates or between T1 and T2. MPSL treatment prevented T 2f and T2s prolongation; however, the duration of MPSL effectiveness was limited. Animals which were treated with MPSL more than 7 h prior to measurements showed T2 prolongation. This study indicates that NMR relaxation times, particularly T2, can be useful in evaluating lung injuries and their treatments. © 1990 Academic Press, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910150204</identifier><identifier>PMID: 2202880</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Endotoxins - adverse effects ; Escherichia coli ; Extravascular Lung Water - analysis ; Investigative techniques, diagnostic techniques (general aspects) ; Lung - analysis ; Lung - drug effects ; Lung - pathology ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Methylprednisolone - therapeutic use ; Pulmonary Edema - diagnosis ; Pulmonary Edema - drug therapy ; Pulmonary Edema - metabolism ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Inbred Strains ; Respiratory system</subject><ispartof>Magnetic resonance in medicine, 1990-08, Vol.15 (2), p.201-210</ispartof><rights>Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910150204$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910150204$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5067870$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2202880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shioya, Sumie</creatorcontrib><creatorcontrib>Haida, Munetaka</creatorcontrib><creatorcontrib>Tsuji, Chizuko</creatorcontrib><creatorcontrib>Ono, Yoshiaki</creatorcontrib><creatorcontrib>Miyairi, Akira</creatorcontrib><creatorcontrib>Fukuzaki, Minoru</creatorcontrib><creatorcontrib>Ohta, Yasuyo</creatorcontrib><creatorcontrib>Yamabayashi, Hajime</creatorcontrib><title>T2 of endotoxin lung injury with and without methylprednisolone treatment</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>NMR relaxation times (T1 and T2) and the water content (WC) of in vitro rat lungs were measured during the course of endotoxin lung injury in rats. Measurements of normal lungs, untreated endotoxin‐injured lungs, and endotoxin‐injured lungs treated with methylprednisolone (MPSL) were compared. The untreated endotoxin lungs showed prolongation of the fast and slow T2 components (T2r and T2s), but no significant changes in T1 or water content. Also, there was no correlation between 1 /WC and relaxation rates or between T1 and T2. MPSL treatment prevented T 2f and T2s prolongation; however, the duration of MPSL effectiveness was limited. Animals which were treated with MPSL more than 7 h prior to measurements showed T2 prolongation. This study indicates that NMR relaxation times, particularly T2, can be useful in evaluating lung injuries and their treatments. © 1990 Academic Press, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Endotoxins - adverse effects</subject><subject>Escherichia coli</subject><subject>Extravascular Lung Water - analysis</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lung - analysis</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Pulmonary Edema - diagnosis</subject><subject>Pulmonary Edema - drug therapy</subject><subject>Pulmonary Edema - metabolism</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Respiratory system</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtP4zAQxq0VCAq7170h5YC4pYzf8RHxKIiXWIE4Wm7sLIbEKbYj6H-_YVuV08zo-32jmQ-h3ximGIAcd7GbYoUBcyDAfqAJ5oSUhCu2hSYgGZQUK7aL9lJ6BQClJNtBO4QAqSqYoKtHUvRN4YLtc__pQ9EO4W_hw-sQl8WHzy-FCfZ_0w-56Fx-WbaL6GzwqW_74IocncmdC_kn2m5Mm9yvdd1HTxfnj6eX5c397Or05Kb0lFBWyrquK9dwI2TVCCqokxYwccBYw8y8JkrVlhBqwVoQFBpqOOa8kbzidA4V3UdHq72L2L8PLmXd-VS7tjXB9UPSUikhuIARPFiDw7xzVi-i70xc6vXvo3641k2qTdtEE2qfNhiH8UL5hakV9uFbt9zIGPRX_nrMX3_nr2__3H5Po7dceX3K7nPjNfFNC0kl1893M_1wJs7gkl7oa_oPsA6H2w</recordid><startdate>199008</startdate><enddate>199008</enddate><creator>Shioya, Sumie</creator><creator>Haida, Munetaka</creator><creator>Tsuji, Chizuko</creator><creator>Ono, Yoshiaki</creator><creator>Miyairi, Akira</creator><creator>Fukuzaki, Minoru</creator><creator>Ohta, Yasuyo</creator><creator>Yamabayashi, Hajime</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199008</creationdate><title>T2 of endotoxin lung injury with and without methylprednisolone treatment</title><author>Shioya, Sumie ; Haida, Munetaka ; Tsuji, Chizuko ; Ono, Yoshiaki ; Miyairi, Akira ; Fukuzaki, Minoru ; Ohta, Yasuyo ; Yamabayashi, Hajime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3234-7ccc8ef5a678f6363e7d012e044f4abc299cd223d0dd0630f3a5155f75853b083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Endotoxins - adverse effects</topic><topic>Escherichia coli</topic><topic>Extravascular Lung Water - analysis</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lung - analysis</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Pulmonary Edema - diagnosis</topic><topic>Pulmonary Edema - drug therapy</topic><topic>Pulmonary Edema - metabolism</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shioya, Sumie</creatorcontrib><creatorcontrib>Haida, Munetaka</creatorcontrib><creatorcontrib>Tsuji, Chizuko</creatorcontrib><creatorcontrib>Ono, Yoshiaki</creatorcontrib><creatorcontrib>Miyairi, Akira</creatorcontrib><creatorcontrib>Fukuzaki, Minoru</creatorcontrib><creatorcontrib>Ohta, Yasuyo</creatorcontrib><creatorcontrib>Yamabayashi, Hajime</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shioya, Sumie</au><au>Haida, Munetaka</au><au>Tsuji, Chizuko</au><au>Ono, Yoshiaki</au><au>Miyairi, Akira</au><au>Fukuzaki, Minoru</au><au>Ohta, Yasuyo</au><au>Yamabayashi, Hajime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T2 of endotoxin lung injury with and without methylprednisolone treatment</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1990-08</date><risdate>1990</risdate><volume>15</volume><issue>2</issue><spage>201</spage><epage>210</epage><pages>201-210</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>NMR relaxation times (T1 and T2) and the water content (WC) of in vitro rat lungs were measured during the course of endotoxin lung injury in rats. Measurements of normal lungs, untreated endotoxin‐injured lungs, and endotoxin‐injured lungs treated with methylprednisolone (MPSL) were compared. The untreated endotoxin lungs showed prolongation of the fast and slow T2 components (T2r and T2s), but no significant changes in T1 or water content. Also, there was no correlation between 1 /WC and relaxation rates or between T1 and T2. MPSL treatment prevented T 2f and T2s prolongation; however, the duration of MPSL effectiveness was limited. Animals which were treated with MPSL more than 7 h prior to measurements showed T2 prolongation. This study indicates that NMR relaxation times, particularly T2, can be useful in evaluating lung injuries and their treatments. © 1990 Academic Press, Inc.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2202880</pmid><doi>10.1002/mrm.1910150204</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Endotoxins - adverse effects Escherichia coli Extravascular Lung Water - analysis Investigative techniques, diagnostic techniques (general aspects) Lung - analysis Lung - drug effects Lung - pathology Magnetic Resonance Spectroscopy - methods Male Medical sciences Methylprednisolone - therapeutic use Pulmonary Edema - diagnosis Pulmonary Edema - drug therapy Pulmonary Edema - metabolism Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Inbred Strains Respiratory system |
| title | T2 of endotoxin lung injury with and without methylprednisolone treatment |
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