Local effects of previous conjunctival incisional surgery and the subsequent outcome of filtration surgery
Purpose: Previous ocular surgery involving conjunctival incision is a risk factor for failure of filtration surgery. To determine whether using adjunctive antimetabolite therapy may have a rational basis, a study was performed to determine whether the conjunctival cellular profile was altered by suc...
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| Veröffentlicht in: | American journal of ophthalmology 1998-06, Vol.125 (6), p.805-818 |
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| creator | Broadway, David C Grierson, Ian Hitchings, Roger A |
| description | Purpose: Previous ocular surgery involving conjunctival incision is a risk factor for failure of filtration surgery. To determine whether using adjunctive antimetabolite therapy may have a rational basis, a study was performed to determine whether the conjunctival cellular profile was altered by such surgery.
Methods: After a mean follow-up of 5.9 years, filtration surgery outcomes for 35 patients who had undergone conjunctival incisional surgery were retrospectively compared with 29 control and 18 matched patients who had not undergone such surgery. At the time of filtration surgery, a conjunctival biopsy specimen was obtained from all 82 patients, and these were quantitatively analyzed by light microscopy in a prospective manner.
Results: Trabeculectomy success for the control group (93%) was significantly higher than for the previous surgery group (38%) (
P < .001). Compared with control tissue, conjunctiva from the patients who had undergone previous surgery contained more fibroblasts (
P < .001,
P < .05), macrophages (
P < .01,
P < .001), and lymphocytes (
P = .001,
P < .01) in both superficial and deep substantia propria (respective
P values). Furthermore, trabeculectomy failure was associated with an increase in number of conjunctival fibroblasts in intraoperative specimens.
Conclusions: Previous ocular surgery involving the conjunctiva increases the number of conjunctival fibroblasts and inflammatory cells. This may account for the increased risk of trabeculectomy failure. Perhaps on this basis, the use of adjunctive medication may be justified in patients who have undergone previous ocular surgery involving conjunctival incision. |
| doi_str_mv | 10.1016/S0002-9394(98)00045-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79966555</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002939498000452</els_id><sourcerecordid>79966555</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-c2a946ea9cff4a2cb272d4bfddfb2a577364754013034030161b58ab5cc30f1c3</originalsourceid><addsrcrecordid>eNqFkUFvGyEQhVHVKHXd_oRIe4iq9LApsLAsp6iK0iaSpRzanhE7O7RY68UB1lL-fXHs-JoTjOa9mccHIReMXjPK2m-_KKW81o0WV7r7Wgoha_6OLFindM06zd6TxUnygXxMaV3KVgl1Ts51K6Ri3YKsVwHsWKFzCDlVwVXbiDsf5lRBmNbzBNnvisBP4JMPU7mmOf7F-FzZaajyPyx1n_BpxilXYc4QNrgf4_yYo83F8mr4RM6cHRN-Pp5L8ufH3e_b-3r1-PPh9vuqBiFlroFbLVq0GpwTlkPPFR9E74bB9dxKpZpWKCkoa2gjaFNQsF52tpcADXUMmiX5cpi7jaHEStlsfAIcRztheZdRWretlLII5UEIMaQU0Zlt9Bsbnw2jZs_YvDA2e4BGd-aFseHFd3FcMPcbHE6uI9TSvzz2bSpwXbR7eCcZ57rrSvgluTnIsMDYeYwmgccJcPCxfIYZgn8jyH_s_Zq7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79966555</pqid></control><display><type>article</type><title>Local effects of previous conjunctival incisional surgery and the subsequent outcome of filtration surgery</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Broadway, David C ; Grierson, Ian ; Hitchings, Roger A</creator><creatorcontrib>Broadway, David C ; Grierson, Ian ; Hitchings, Roger A</creatorcontrib><description><![CDATA[Purpose: Previous ocular surgery involving conjunctival incision is a risk factor for failure of filtration surgery. To determine whether using adjunctive antimetabolite therapy may have a rational basis, a study was performed to determine whether the conjunctival cellular profile was altered by such surgery.
Methods: After a mean follow-up of 5.9 years, filtration surgery outcomes for 35 patients who had undergone conjunctival incisional surgery were retrospectively compared with 29 control and 18 matched patients who had not undergone such surgery. At the time of filtration surgery, a conjunctival biopsy specimen was obtained from all 82 patients, and these were quantitatively analyzed by light microscopy in a prospective manner.
Results: Trabeculectomy success for the control group (93%) was significantly higher than for the previous surgery group (38%) (
P < .001). Compared with control tissue, conjunctiva from the patients who had undergone previous surgery contained more fibroblasts (
P < .001,
P < .05), macrophages (
P < .01,
P < .001), and lymphocytes (
P = .001,
P < .01) in both superficial and deep substantia propria (respective
P values). Furthermore, trabeculectomy failure was associated with an increase in number of conjunctival fibroblasts in intraoperative specimens.
Conclusions: Previous ocular surgery involving the conjunctiva increases the number of conjunctival fibroblasts and inflammatory cells. This may account for the increased risk of trabeculectomy failure. Perhaps on this basis, the use of adjunctive medication may be justified in patients who have undergone previous ocular surgery involving conjunctival incision.]]></description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(98)00045-2</identifier><identifier>PMID: 9645718</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Conjunctiva - pathology ; Conjunctiva - surgery ; Female ; Fibroblasts - pathology ; Follow-Up Studies ; Glaucoma - surgery ; Humans ; Lymphocytes - pathology ; Macrophages - pathology ; Male ; Medical sciences ; Middle Aged ; Postoperative Complications ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit ; Trabeculectomy - adverse effects ; Treatment Outcome</subject><ispartof>American journal of ophthalmology, 1998-06, Vol.125 (6), p.805-818</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-c2a946ea9cff4a2cb272d4bfddfb2a577364754013034030161b58ab5cc30f1c3</citedby><cites>FETCH-LOGICAL-c455t-c2a946ea9cff4a2cb272d4bfddfb2a577364754013034030161b58ab5cc30f1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939498000452$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2298830$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9645718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broadway, David C</creatorcontrib><creatorcontrib>Grierson, Ian</creatorcontrib><creatorcontrib>Hitchings, Roger A</creatorcontrib><title>Local effects of previous conjunctival incisional surgery and the subsequent outcome of filtration surgery</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description><![CDATA[Purpose: Previous ocular surgery involving conjunctival incision is a risk factor for failure of filtration surgery. To determine whether using adjunctive antimetabolite therapy may have a rational basis, a study was performed to determine whether the conjunctival cellular profile was altered by such surgery.
Methods: After a mean follow-up of 5.9 years, filtration surgery outcomes for 35 patients who had undergone conjunctival incisional surgery were retrospectively compared with 29 control and 18 matched patients who had not undergone such surgery. At the time of filtration surgery, a conjunctival biopsy specimen was obtained from all 82 patients, and these were quantitatively analyzed by light microscopy in a prospective manner.
Results: Trabeculectomy success for the control group (93%) was significantly higher than for the previous surgery group (38%) (
P < .001). Compared with control tissue, conjunctiva from the patients who had undergone previous surgery contained more fibroblasts (
P < .001,
P < .05), macrophages (
P < .01,
P < .001), and lymphocytes (
P = .001,
P < .01) in both superficial and deep substantia propria (respective
P values). Furthermore, trabeculectomy failure was associated with an increase in number of conjunctival fibroblasts in intraoperative specimens.
Conclusions: Previous ocular surgery involving the conjunctiva increases the number of conjunctival fibroblasts and inflammatory cells. This may account for the increased risk of trabeculectomy failure. Perhaps on this basis, the use of adjunctive medication may be justified in patients who have undergone previous ocular surgery involving conjunctival incision.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Conjunctiva - pathology</subject><subject>Conjunctiva - surgery</subject><subject>Female</subject><subject>Fibroblasts - pathology</subject><subject>Follow-Up Studies</subject><subject>Glaucoma - surgery</subject><subject>Humans</subject><subject>Lymphocytes - pathology</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Trabeculectomy - adverse effects</subject><subject>Treatment Outcome</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvGyEQhVHVKHXd_oRIe4iq9LApsLAsp6iK0iaSpRzanhE7O7RY68UB1lL-fXHs-JoTjOa9mccHIReMXjPK2m-_KKW81o0WV7r7Wgoha_6OLFindM06zd6TxUnygXxMaV3KVgl1Ts51K6Ri3YKsVwHsWKFzCDlVwVXbiDsf5lRBmNbzBNnvisBP4JMPU7mmOf7F-FzZaajyPyx1n_BpxilXYc4QNrgf4_yYo83F8mr4RM6cHRN-Pp5L8ufH3e_b-3r1-PPh9vuqBiFlroFbLVq0GpwTlkPPFR9E74bB9dxKpZpWKCkoa2gjaFNQsF52tpcADXUMmiX5cpi7jaHEStlsfAIcRztheZdRWretlLII5UEIMaQU0Zlt9Bsbnw2jZs_YvDA2e4BGd-aFseHFd3FcMPcbHE6uI9TSvzz2bSpwXbR7eCcZ57rrSvgluTnIsMDYeYwmgccJcPCxfIYZgn8jyH_s_Zq7</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Broadway, David C</creator><creator>Grierson, Ian</creator><creator>Hitchings, Roger A</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Local effects of previous conjunctival incisional surgery and the subsequent outcome of filtration surgery</title><author>Broadway, David C ; Grierson, Ian ; Hitchings, Roger A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-c2a946ea9cff4a2cb272d4bfddfb2a577364754013034030161b58ab5cc30f1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Conjunctiva - pathology</topic><topic>Conjunctiva - surgery</topic><topic>Female</topic><topic>Fibroblasts - pathology</topic><topic>Follow-Up Studies</topic><topic>Glaucoma - surgery</topic><topic>Humans</topic><topic>Lymphocytes - pathology</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Complications</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Trabeculectomy - adverse effects</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broadway, David C</creatorcontrib><creatorcontrib>Grierson, Ian</creatorcontrib><creatorcontrib>Hitchings, Roger A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broadway, David C</au><au>Grierson, Ian</au><au>Hitchings, Roger A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local effects of previous conjunctival incisional surgery and the subsequent outcome of filtration surgery</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>125</volume><issue>6</issue><spage>805</spage><epage>818</epage><pages>805-818</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract><![CDATA[Purpose: Previous ocular surgery involving conjunctival incision is a risk factor for failure of filtration surgery. To determine whether using adjunctive antimetabolite therapy may have a rational basis, a study was performed to determine whether the conjunctival cellular profile was altered by such surgery.
Methods: After a mean follow-up of 5.9 years, filtration surgery outcomes for 35 patients who had undergone conjunctival incisional surgery were retrospectively compared with 29 control and 18 matched patients who had not undergone such surgery. At the time of filtration surgery, a conjunctival biopsy specimen was obtained from all 82 patients, and these were quantitatively analyzed by light microscopy in a prospective manner.
Results: Trabeculectomy success for the control group (93%) was significantly higher than for the previous surgery group (38%) (
P < .001). Compared with control tissue, conjunctiva from the patients who had undergone previous surgery contained more fibroblasts (
P < .001,
P < .05), macrophages (
P < .01,
P < .001), and lymphocytes (
P = .001,
P < .01) in both superficial and deep substantia propria (respective
P values). Furthermore, trabeculectomy failure was associated with an increase in number of conjunctival fibroblasts in intraoperative specimens.
Conclusions: Previous ocular surgery involving the conjunctiva increases the number of conjunctival fibroblasts and inflammatory cells. This may account for the increased risk of trabeculectomy failure. Perhaps on this basis, the use of adjunctive medication may be justified in patients who have undergone previous ocular surgery involving conjunctival incision.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9645718</pmid><doi>10.1016/S0002-9394(98)00045-2</doi><tpages>14</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Conjunctiva - pathology Conjunctiva - surgery Female Fibroblasts - pathology Follow-Up Studies Glaucoma - surgery Humans Lymphocytes - pathology Macrophages - pathology Male Medical sciences Middle Aged Postoperative Complications Prospective Studies Retrospective Studies Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Trabeculectomy - adverse effects Treatment Outcome |
| title | Local effects of previous conjunctival incisional surgery and the subsequent outcome of filtration surgery |
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