Inhibitors of human renin. Cyclic peptide analogs containing a D-Phe-Lys-D-Trp sequence

Cyclic peptides containing a D-phenylalanine and a D-tryptophan residue have been synthesized and tested as inhibitors of human renin. Most of these are tripeptide derivatives of the type CO(CH2)3CO-D-Phe-Lys-D-Trp- or COCH2NHCH2CO-D-Phe-Lys-D-Trp- in which the individual side-chain methylene groups...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-09, Vol.33 (9), p.2560-2568
Hauptverfasser:	Dutta, Anand S, Gormley, James J, McLachlan, Peter F, Major, John S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Chemical Phenomena Chemistry D-phenylalanine D-tryptophan Humans Molecular Sequence Data Oligopeptides - chemical synthesis Oligopeptides - pharmacology Peptides, Cyclic - chemical synthesis Peptides, Cyclic - pharmacology Renin - antagonists & inhibitors Structure-Activity Relationship Swine
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