Expression of Multidrug-Resistance (MDR1) Gene in Normal Epithelia and in Invasive Carcinomas of the Uterine Cervix
Total RNA from 92 invasive cervical cancers was analyzed for the presence of multidrug-resistance (MDR1) gene (also known as PGY1) transcripts. A 4.5-kilobase MDR1 transcript band was detected in 40 (43%) of 92 invasive cervical carcinomas and in 15 (68%) of 22 normal cervices. MDR1 levels were low...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1990-09, Vol.82 (18), p.1493-1496 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Riou, Guy F. Zhou, Dany Ahomadegbe, Jean-Charles Gabillot, Michèle Duvillard, Pierre Lhomme, Catherine |
| description | Total RNA from 92 invasive cervical cancers was analyzed for the presence of multidrug-resistance (MDR1) gene (also known as PGY1) transcripts. A 4.5-kilobase MDR1 transcript band was detected in 40 (43%) of 92 invasive cervical carcinomas and in 15 (68%) of 22 normal cervices. MDR1 levels were low [mean, 2.5 arbitrary units (U)] except in one liver metastasis (50 U) treated with a drug regimen including vincristine. Of eight carcinomas treated by radiotherapy and/or chemotherapy, seven (88%) exhibited MDR1 transcripts as compared with 24 (35%) of 69 untreated carcinomas (Fisher's exact test; P =.01). In conclusion, our data suggest that the MDR1 gene plays a role in drug resistance of certain cervical cancers, but also that other mechanisms may be involved. [J Natl Cancer Inst 82: 1493–1496, 1990] |
| doi_str_mv | 10.1093/jnci/82.18.1493 |
| format | Article |
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A 4.5-kilobase MDR1 transcript band was detected in 40 (43%) of 92 invasive cervical carcinomas and in 15 (68%) of 22 normal cervices. MDR1 levels were low [mean, 2.5 arbitrary units (U)] except in one liver metastasis (50 U) treated with a drug regimen including vincristine. Of eight carcinomas treated by radiotherapy and/or chemotherapy, seven (88%) exhibited MDR1 transcripts as compared with 24 (35%) of 69 untreated carcinomas (Fisher's exact test; P =.01). In conclusion, our data suggest that the MDR1 gene plays a role in drug resistance of certain cervical cancers, but also that other mechanisms may be involved. 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[J Natl Cancer Inst 82: 1493–1496, 1990]</description><subject>Adenocarcinoma - genetics</subject><subject>Blotting, Northern</subject><subject>carcinoma</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma in Situ - genetics</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Cervix Uteri - drug effects</subject><subject>Drug Resistance - genetics</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Humans</subject><subject>MDR1 gene</subject><subject>Neoplasm Staging</subject><subject>Nucleic Acid Hybridization</subject><subject>RNA - analysis</subject><subject>Uterine Cervical Neoplasms - genetics</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxa0KVELbMycknxAcNvHYa699RGloKrXQVq1AvViOdxZc9iPYu1H479lVKjgyl5Hm_eaNNI-QN8DmwIxYPLU-LDSfg55DbsQRmUGuWMaByRdkxhgvMq2L_BV5ndITG8vw_JgcgzKFyNWMpNV-GzGl0LW0q-j1UPehjMP37A5TSL1rPdL31-d38IFeYIs0tPRzFxtX09U29D-wDo66tpzml-3OpbBDunTRh7ZrXJosR4g-9BjDuL3EuAv7U_KycnXCs-d-Qh4-re6X6-zqy8Xl8uNV5oWCPtM8h0prvfFMeeRqIyAvSg8cKq41FhUYgSArkMgkH6cahAEhN75UYIwQJ-TdwXcbu18Dpt42IXmsa9diNyRbGKOk5MV_QZCFVEZN4OIA-tilFLGy2xgaF39bYHbKw055WM0taDvlMW68fbYeNg2W__hDAKOeHfTx2bj_K7v40473CmnX3x7tOV_ffH28vbe34g91o5UF</recordid><startdate>19900919</startdate><enddate>19900919</enddate><creator>Riou, Guy F.</creator><creator>Zhou, Dany</creator><creator>Ahomadegbe, Jean-Charles</creator><creator>Gabillot, Michèle</creator><creator>Duvillard, Pierre</creator><creator>Lhomme, Catherine</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19900919</creationdate><title>Expression of Multidrug-Resistance (MDR1) Gene in Normal Epithelia and in Invasive Carcinomas of the Uterine Cervix</title><author>Riou, Guy F. ; 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| ispartof | JNCI : Journal of the National Cancer Institute, 1990-09, Vol.82 (18), p.1493-1496 |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adenocarcinoma - genetics Blotting, Northern carcinoma Carcinoma - genetics Carcinoma in Situ - genetics Carcinoma, Squamous Cell - genetics Cervix Uteri - drug effects Drug Resistance - genetics Female Gene Expression Genes Humans MDR1 gene Neoplasm Staging Nucleic Acid Hybridization RNA - analysis Uterine Cervical Neoplasms - genetics |
| title | Expression of Multidrug-Resistance (MDR1) Gene in Normal Epithelia and in Invasive Carcinomas of the Uterine Cervix |
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