Characterization of the specificity of peptide binding to four DR haplotypes

This study describes the establishment of a peptide-binding assay for purified, detergent-solubilized DR molecules. For each of the DR specificities and peptides studied, a unique pattern of interaction was observed. Excellent correlation was detected between the DR1-, 2-, 5-, and 52a-binding capaci...

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Veröffentlicht in:	The Journal of immunology (1950) 1990-09, Vol.145 (6), p.1799-1808
Hauptverfasser:	O'Sullivan, D, Sidney, J, Appella, E, Walker, L, Phillips, L, Colon, SM, Miles, C, Chesnut, RW, Sette, A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Antigens beta 2-Microglobulin - genetics beta 2-Microglobulin - immunology Biological and medical sciences Cell Line Fundamental and applied biological sciences. Psychology Fundamental immunology Haplotypes Herpesvirus 4, Human - genetics Herpesvirus 4, Human - immunology Histocompatibility antigens (hla, h-2 and other systems) HIV - genetics HIV - immunology HLA-DR Antigens - metabolism Humans In Vitro Techniques Lymphocytes - metabolism Major Histocompatibility Complex Micrococcal Nuclease - genetics Micrococcal Nuclease - immunology Molecular immunology Molecular Sequence Data Muramidase - genetics Muramidase - immunology Peptides - chemical synthesis Peptides - metabolism Phospholipases A - genetics Phospholipases A - immunology Protein Binding Viral Proteins - genetics Viral Proteins - immunology
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