The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention
The loss of body cell mass (bcm) in senescence and wasting is poorly understood. We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect rel...
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| Veröffentlicht in: | Blood 1998-07, Vol.92 (1), p.59-67 |
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| creator | HACK, V BREITKREUTZ, R KINSCHERF, R RÖHRER, H BÄRTSCH, P TAUT, F BENNER, A DRÖGE, W |
| description | The loss of body cell mass (bcm) in senescence and wasting is poorly understood. We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect relationship was suggested by two independent studies with N-acetyl-cysteine (NAC). NAC caused an increase in the bcm of healthy persons with high plasma cystine/thiol ratios, and treatment of cancer patients with NAC plus interleukin-2 caused an increase in bcm, plasma albumin, and functional capacity. Albumin levels below 680 micromol/L were associated with an increase in body water. Our studies suggest that the shift in the redox state may contribute to the loss of bcm and may provide a quantitative guideline for therapeutic intervention. Treatment of cancer patients with thiol-containing antioxidants may improve the quality of life. |
| doi_str_mv | 10.1182/blood.v92.1.59.413a05_59_67 |
| format | Article |
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We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect relationship was suggested by two independent studies with N-acetyl-cysteine (NAC). NAC caused an increase in the bcm of healthy persons with high plasma cystine/thiol ratios, and treatment of cancer patients with NAC plus interleukin-2 caused an increase in bcm, plasma albumin, and functional capacity. Albumin levels below 680 micromol/L were associated with an increase in body water. Our studies suggest that the shift in the redox state may contribute to the loss of bcm and may provide a quantitative guideline for therapeutic intervention. Treatment of cancer patients with thiol-containing antioxidants may improve the quality of life.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.v92.1.59.413a05_59_67</identifier><identifier>PMID: 9639500</identifier><language>eng</language><publisher>Washington, DC: The Americain Society of Hematology</publisher><subject>Acetylcysteine - administration & dosage ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging - metabolism ; Antineoplastic agents ; Biological and medical sciences ; Cell Death ; Child ; Child, Preschool ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Cystine - blood ; Female ; Free Radical Scavengers - administration & dosage ; Free Radical Scavengers - therapeutic use ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Neoplasms - physiopathology ; Oxidation-Reduction - drug effects ; Pharmacology. 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We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect relationship was suggested by two independent studies with N-acetyl-cysteine (NAC). NAC caused an increase in the bcm of healthy persons with high plasma cystine/thiol ratios, and treatment of cancer patients with NAC plus interleukin-2 caused an increase in bcm, plasma albumin, and functional capacity. Albumin levels below 680 micromol/L were associated with an increase in body water. Our studies suggest that the shift in the redox state may contribute to the loss of bcm and may provide a quantitative guideline for therapeutic intervention. Treatment of cancer patients with thiol-containing antioxidants may improve the quality of life.</description><subject>Acetylcysteine - administration & dosage</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - metabolism</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Death</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Cystine - blood</subject><subject>Female</subject><subject>Free Radical Scavengers - administration & dosage</subject><subject>Free Radical Scavengers - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - physiopathology</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Serum Albumin - metabolism</subject><subject>Sulfhydryl Compounds - blood</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtqHDEQRUWIccaPTwgIHLLrTunV3SKrYOIHGLKxvRUadcnu0CONJY2d_L0148F4pRL3lKp0CDlj0DI28B_LOcaxfda8Za3SrWTCgjJKm67_RBZM8aEB4PCZLACga6Tu2RdylPNfACYFV4fkUHdCK4AFwdtHpAnH-I_mYgtSm6mlLqaE8_YaPc0YMDsMroZhpC82lyk87OodXGx6wEJ9TLQ8YrJr3JTJ0SkUTM8YyhTDCTnwds54uj-Pyd3F79vzq-bmz-X1-a-bxknGSuPGpZZWj1r6upwUWjuU0CFY5QEcHzonROf6WkghrUfdg_OKDSBh8FaJY_L97d11ik8bzMWsprr6PNuAcZNNr-vHe8Ur-PMNdCnmnNCbdZpWNv03DMxWstlJNveaG7ZV-1Fy7f66H7NZrnB8791brfm3fW6zs7NPNrgpv2NcSC4q9gpk_IhH</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>HACK, V</creator><creator>BREITKREUTZ, R</creator><creator>KINSCHERF, R</creator><creator>RÖHRER, H</creator><creator>BÄRTSCH, P</creator><creator>TAUT, F</creator><creator>BENNER, A</creator><creator>DRÖGE, W</creator><general>The Americain Society of Hematology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention</title><author>HACK, V ; BREITKREUTZ, R ; KINSCHERF, R ; RÖHRER, H ; BÄRTSCH, P ; TAUT, F ; BENNER, A ; DRÖGE, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-cdb94a9d94f5004399ce406e0a5f00c286c336c7286434afe970cf5180408fa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acetylcysteine - administration & dosage</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - metabolism</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cell Death</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Cystine - blood</topic><topic>Female</topic><topic>Free Radical Scavengers - administration & dosage</topic><topic>Free Radical Scavengers - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - physiopathology</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Serum Albumin - metabolism</topic><topic>Sulfhydryl Compounds - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HACK, V</creatorcontrib><creatorcontrib>BREITKREUTZ, R</creatorcontrib><creatorcontrib>KINSCHERF, R</creatorcontrib><creatorcontrib>RÖHRER, H</creatorcontrib><creatorcontrib>BÄRTSCH, P</creatorcontrib><creatorcontrib>TAUT, F</creatorcontrib><creatorcontrib>BENNER, A</creatorcontrib><creatorcontrib>DRÖGE, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HACK, V</au><au>BREITKREUTZ, R</au><au>KINSCHERF, R</au><au>RÖHRER, H</au><au>BÄRTSCH, P</au><au>TAUT, F</au><au>BENNER, A</au><au>DRÖGE, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>92</volume><issue>1</issue><spage>59</spage><epage>67</epage><pages>59-67</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>The loss of body cell mass (bcm) in senescence and wasting is poorly understood. We now show that the plasma cystine/acid soluble thiol ratio, ie, an indicator of the redox state, is increased in old age and cancer patients and correlated with a decrease in bcm and plasma albumin. A cause/effect relationship was suggested by two independent studies with N-acetyl-cysteine (NAC). NAC caused an increase in the bcm of healthy persons with high plasma cystine/thiol ratios, and treatment of cancer patients with NAC plus interleukin-2 caused an increase in bcm, plasma albumin, and functional capacity. Albumin levels below 680 micromol/L were associated with an increase in body water. Our studies suggest that the shift in the redox state may contribute to the loss of bcm and may provide a quantitative guideline for therapeutic intervention. Treatment of cancer patients with thiol-containing antioxidants may improve the quality of life.</abstract><cop>Washington, DC</cop><pub>The Americain Society of Hematology</pub><pmid>9639500</pmid><doi>10.1182/blood.v92.1.59.413a05_59_67</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acetylcysteine - administration & dosage Adolescent Adult Aged Aged, 80 and over Aging - metabolism Antineoplastic agents Biological and medical sciences Cell Death Child Child, Preschool Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cystine - blood Female Free Radical Scavengers - administration & dosage Free Radical Scavengers - therapeutic use Humans Male Medical sciences Middle Aged Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - physiopathology Oxidation-Reduction - drug effects Pharmacology. Drug treatments Serum Albumin - metabolism Sulfhydryl Compounds - blood |
| title | The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention |
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