An NFAT-Dependent Enhancer Is Necessary for Anti-IgM-Mediated Induction of Murine CD5 Expression in Primary Splenic B Cells

CD5 is a 67-kDa membrane glycoprotein the expression of which in murine splenic B cells is induced by surface IgM cross-linking. To analyze this induction, we transiently transfected primary splenic B cells with luciferase reporter constructs driven by various wild-type and mutated CD5 5'-flank...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-07, Vol.161 (1), p.277-285
Hauptverfasser:	Berland, Robert, Wortis, Henry H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Anti-Idiotypic - physiology B-Lymphocytes - immunology B-Lymphocytes - metabolism Base Composition Base Sequence Binding Sites - genetics CD5 Antigens - biosynthesis CD5 Antigens - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Enhancer Elements, Genetic - immunology Gene Expression Regulation - immunology Histones - genetics Immunoglobulin M - immunology Lymphocyte Activation - genetics Mice Mice, Inbred BALB C Molecular Sequence Data NFATC Transcription Factors Nuclear Proteins Promoter Regions, Genetic - immunology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ets Spleen - cytology Spleen - immunology Spleen - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology
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