Synthesis of 1-methyl-4-( N-aroyl)-piperidinamides with anti-inflammatory and analgesic activities

Two series of 1-methyl-4-( N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-( N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 1998-03, Vol.53 (3), p.233-240
Hauptverfasser:	Pau, Amedeo, Boatto, Gianpiero, Cerri, Riccardo, Palagiano, Francesco, Filippelli, Walter, Falcone, Giuseppe, Lampa, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - pharmacology Analgesic agents Analgesics - chemical synthesis Analgesics - pharmacology Animals Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Edema - drug therapy Female Male Medical sciences Mice Molecular Structure Pharmacology. Drug treatments Piperidinamides Piperidines - chemical synthesis Piperidines - pharmacology Rats
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