Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy
Background Allergenic crossreactivity of pollen and foods due to the antigeneic similarity of oligopeptides is a well established clinical phenomenon. Objective To determine the immunopathological relevance of antigen presentation, we analysed the HLA class‐II genotype of patients with either pollen...
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| Veröffentlicht in: | Clinical and experimental allergy 1998-04, Vol.28 (4), p.434-441 |
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| creator | BOEHNCKE, W.-H LOELIGER, C KUEHNL, P KALBACHER, H BÖHM, B. O GALL, H |
| description | Background
Allergenic crossreactivity of pollen and foods due to the antigeneic similarity of oligopeptides is a well established clinical phenomenon.
Objective
To determine the immunopathological relevance of antigen presentation, we analysed the HLA class‐II genotype of patients with either pollen allergy or pollen associated food allergy.
Methods
One hundred and twenty patients with pollen allergy and 80 patients with pollen associated food allergy were evaluated by skin‐ prick tests, RAST, and HLA class‐II genotyping. The control population comprised 4251 healthy blood and bone marrow donors.
Results
Monovalent pollen allergy was observed in 57% (n = 68) of patients with pollinosis (57x grass pollen, 11x birch pollen), but only in 15% (n = 12) of patients with food allergy (9x grass pollen, 3x birch pollen). Hazelnut (71%), almond (65%), walnut (44%) and apple (41%) were the most common food allergens and frequently associated with birch pollen allergy. Grass pollen allergy was associated with an increased frequency of HLA‐DQB1*0301 (RR = 2.3; EF = 0.4; P = 0.0016) when compared with the control population. HLA‐DRB1*08 confered a sixfold higher risk for peanut allergy (EF = 0.3; P = 0.0013) and ‐DRB1*12 a 13‐fold higher risk for carrot allergy (EF = 0.3; P |
| doi_str_mv | 10.1046/j.1365-2222.1998.00246.x |
| format | Article |
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Allergenic crossreactivity of pollen and foods due to the antigeneic similarity of oligopeptides is a well established clinical phenomenon.
Objective
To determine the immunopathological relevance of antigen presentation, we analysed the HLA class‐II genotype of patients with either pollen allergy or pollen associated food allergy.
Methods
One hundred and twenty patients with pollen allergy and 80 patients with pollen associated food allergy were evaluated by skin‐ prick tests, RAST, and HLA class‐II genotyping. The control population comprised 4251 healthy blood and bone marrow donors.
Results
Monovalent pollen allergy was observed in 57% (n = 68) of patients with pollinosis (57x grass pollen, 11x birch pollen), but only in 15% (n = 12) of patients with food allergy (9x grass pollen, 3x birch pollen). Hazelnut (71%), almond (65%), walnut (44%) and apple (41%) were the most common food allergens and frequently associated with birch pollen allergy. Grass pollen allergy was associated with an increased frequency of HLA‐DQB1*0301 (RR = 2.3; EF = 0.4; P = 0.0016) when compared with the control population. HLA‐DRB1*08 confered a sixfold higher risk for peanut allergy (EF = 0.3; P = 0.0013) and ‐DRB1*12 a 13‐fold higher risk for carrot allergy (EF = 0.3; P < 0.000001). The differences on allele frequencies detected among patients with food allergies diminished or turned statistically insignificant when their genotypes were directly compared to those of patients with the corresponding pollen allergies. This was found in the case of birch pollen associated hazel nut allergy for the extended haplotype HLA‐DRB1*01, ‐DQA1*0101, ‐DQB1*0501 as well as in grass pollen associated peanut allergy for HLA‐DRB1*08 (from RR = 6, P = 0.0013 to insignificant) and in birch pollen associated carrot allergy for HLA‐DRB1*12 (from RR = 13, P < 0.000001 to insignificant).
Conclusion
We were able to identify HLA class‐II alleles associated with some allergies thus indicating that these alleles might confer susceptibility to the respective allergens. Similarities at the level of the HLA class‐II genotype parallel the empirical finding of distinct cross‐reactivity patterns thus complementing investigations of IgE specificities. Our observations provide evidence for the major importance of antigen presentation on the manifestation of distinct crossreactivity patterns.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1046/j.1365-2222.1998.00246.x</identifier><identifier>PMID: 9641569</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Alleles ; Allergens - adverse effects ; Allergens - immunology ; Allergic diseases ; allergy ; antigen presentation ; Biological and medical sciences ; carrot ; crossreactivity ; Daucus carota - immunology ; Disease Susceptibility - immunology ; Female ; food ; Food Hypersensitivity - epidemiology ; Food Hypersensitivity - etiology ; Food Hypersensitivity - immunology ; Genetic Predisposition to Disease ; Genotype ; grass ; HLA ; HLA-DQ Antigens - genetics ; HLA-DQ Antigens - immunology ; HLA-DR Antigens - genetics ; HLA-DR Antigens - immunology ; Humans ; Immunopathology ; Male ; Medical sciences ; Other localizations ; peanut ; Poaceae - immunology ; pollen ; Pollen - adverse effects ; Pollen - immunology ; Radioallergosorbent Test ; Respiratory Hypersensitivity - epidemiology ; Respiratory Hypersensitivity - etiology ; Respiratory Hypersensitivity - immunology ; risk factor ; Skin Tests ; Time Factors ; Trees - chemistry ; Trees - immunology</subject><ispartof>Clinical and experimental allergy, 1998-04, Vol.28 (4), p.434-441</ispartof><rights>Blackwell Science Ltd, Oxford</rights><rights>1998 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Apr 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5236-7f99d36c8d38739dd288d5145c15c87e2238d97cd52b2156c5a47f371564e7a3</citedby><cites>FETCH-LOGICAL-c5236-7f99d36c8d38739dd288d5145c15c87e2238d97cd52b2156c5a47f371564e7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2222.1998.00246.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2222.1998.00246.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2268277$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9641569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOEHNCKE, W.-H</creatorcontrib><creatorcontrib>LOELIGER, C</creatorcontrib><creatorcontrib>KUEHNL, P</creatorcontrib><creatorcontrib>KALBACHER, H</creatorcontrib><creatorcontrib>BÖHM, B. O</creatorcontrib><creatorcontrib>GALL, H</creatorcontrib><title>Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy</title><title>Clinical and experimental allergy</title><addtitle>Clinical & Experimental Allergy</addtitle><description>Background
Allergenic crossreactivity of pollen and foods due to the antigeneic similarity of oligopeptides is a well established clinical phenomenon.
Objective
To determine the immunopathological relevance of antigen presentation, we analysed the HLA class‐II genotype of patients with either pollen allergy or pollen associated food allergy.
Methods
One hundred and twenty patients with pollen allergy and 80 patients with pollen associated food allergy were evaluated by skin‐ prick tests, RAST, and HLA class‐II genotyping. The control population comprised 4251 healthy blood and bone marrow donors.
Results
Monovalent pollen allergy was observed in 57% (n = 68) of patients with pollinosis (57x grass pollen, 11x birch pollen), but only in 15% (n = 12) of patients with food allergy (9x grass pollen, 3x birch pollen). Hazelnut (71%), almond (65%), walnut (44%) and apple (41%) were the most common food allergens and frequently associated with birch pollen allergy. Grass pollen allergy was associated with an increased frequency of HLA‐DQB1*0301 (RR = 2.3; EF = 0.4; P = 0.0016) when compared with the control population. HLA‐DRB1*08 confered a sixfold higher risk for peanut allergy (EF = 0.3; P = 0.0013) and ‐DRB1*12 a 13‐fold higher risk for carrot allergy (EF = 0.3; P < 0.000001). The differences on allele frequencies detected among patients with food allergies diminished or turned statistically insignificant when their genotypes were directly compared to those of patients with the corresponding pollen allergies. This was found in the case of birch pollen associated hazel nut allergy for the extended haplotype HLA‐DRB1*01, ‐DQA1*0101, ‐DQB1*0501 as well as in grass pollen associated peanut allergy for HLA‐DRB1*08 (from RR = 6, P = 0.0013 to insignificant) and in birch pollen associated carrot allergy for HLA‐DRB1*12 (from RR = 13, P < 0.000001 to insignificant).
Conclusion
We were able to identify HLA class‐II alleles associated with some allergies thus indicating that these alleles might confer susceptibility to the respective allergens. Similarities at the level of the HLA class‐II genotype parallel the empirical finding of distinct cross‐reactivity patterns thus complementing investigations of IgE specificities. Our observations provide evidence for the major importance of antigen presentation on the manifestation of distinct crossreactivity patterns.</description><subject>Alleles</subject><subject>Allergens - adverse effects</subject><subject>Allergens - immunology</subject><subject>Allergic diseases</subject><subject>allergy</subject><subject>antigen presentation</subject><subject>Biological and medical sciences</subject><subject>carrot</subject><subject>crossreactivity</subject><subject>Daucus carota - immunology</subject><subject>Disease Susceptibility - immunology</subject><subject>Female</subject><subject>food</subject><subject>Food Hypersensitivity - epidemiology</subject><subject>Food Hypersensitivity - etiology</subject><subject>Food Hypersensitivity - immunology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>grass</subject><subject>HLA</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ Antigens - immunology</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other localizations</subject><subject>peanut</subject><subject>Poaceae - immunology</subject><subject>pollen</subject><subject>Pollen - adverse effects</subject><subject>Pollen - immunology</subject><subject>Radioallergosorbent Test</subject><subject>Respiratory Hypersensitivity - epidemiology</subject><subject>Respiratory Hypersensitivity - etiology</subject><subject>Respiratory Hypersensitivity - immunology</subject><subject>risk factor</subject><subject>Skin Tests</subject><subject>Time Factors</subject><subject>Trees - chemistry</subject><subject>Trees - immunology</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi0EKqHwE5AshLjt4vW3JS4hLU1RBKKqxNFybG_lsFmn9q6a_Hucj-bACV888vu8M-MZAGCD6gZR_nlVN4SzCpdTN0rJGiFMeb19ASZn4SWYIMVoJaSir8GbnFcIIcKUvAAXitOGcTUBT7fO90NogzVDiD2MLZwvptXVHTS9g9XVL2i6znc-Qxv71qcU-geYx2z9ZgjL0IVhB4cIN7FQ_YFND7uD9_kp52iDGbyDbYzuGXkLXrWmy_7d6b4E99-u72fzavHz5nY2XVSWYcIr0SrlCLfSESmIcg5L6VhDmW2YlcJjTKRTwjqGl7j8yDJDRUtECakXhlyCT8e0mxQfR58HvQ6l964zvY9j1kIpjpGiBfzwD7iKY-pLa7rMV6FSvSmQPEI2xZyTb_UmhbVJO90gvd-LXun9-PV-_Huf1Ie96G2xvj_lH5dr787G0yKK_vGkm2xN1ybT25DPGMZcYiEK9uWIPYXO7_67vJ5dT0tQ7NXRHvLgt2e7SX80F0Qw_fvHjUb06_c7Seaakr8jn7aj</recordid><startdate>199804</startdate><enddate>199804</enddate><creator>BOEHNCKE, W.-H</creator><creator>LOELIGER, C</creator><creator>KUEHNL, P</creator><creator>KALBACHER, H</creator><creator>BÖHM, B. O</creator><creator>GALL, H</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199804</creationdate><title>Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy</title><author>BOEHNCKE, W.-H ; LOELIGER, C ; KUEHNL, P ; KALBACHER, H ; BÖHM, B. O ; GALL, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5236-7f99d36c8d38739dd288d5145c15c87e2238d97cd52b2156c5a47f371564e7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Alleles</topic><topic>Allergens - adverse effects</topic><topic>Allergens - immunology</topic><topic>Allergic diseases</topic><topic>allergy</topic><topic>antigen presentation</topic><topic>Biological and medical sciences</topic><topic>carrot</topic><topic>crossreactivity</topic><topic>Daucus carota - immunology</topic><topic>Disease Susceptibility - immunology</topic><topic>Female</topic><topic>food</topic><topic>Food Hypersensitivity - epidemiology</topic><topic>Food Hypersensitivity - etiology</topic><topic>Food Hypersensitivity - immunology</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>grass</topic><topic>HLA</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ Antigens - immunology</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR Antigens - immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other localizations</topic><topic>peanut</topic><topic>Poaceae - immunology</topic><topic>pollen</topic><topic>Pollen - adverse effects</topic><topic>Pollen - immunology</topic><topic>Radioallergosorbent Test</topic><topic>Respiratory Hypersensitivity - epidemiology</topic><topic>Respiratory Hypersensitivity - etiology</topic><topic>Respiratory Hypersensitivity - immunology</topic><topic>risk factor</topic><topic>Skin Tests</topic><topic>Time Factors</topic><topic>Trees - chemistry</topic><topic>Trees - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOEHNCKE, W.-H</creatorcontrib><creatorcontrib>LOELIGER, C</creatorcontrib><creatorcontrib>KUEHNL, P</creatorcontrib><creatorcontrib>KALBACHER, H</creatorcontrib><creatorcontrib>BÖHM, B. O</creatorcontrib><creatorcontrib>GALL, H</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOEHNCKE, W.-H</au><au>LOELIGER, C</au><au>KUEHNL, P</au><au>KALBACHER, H</au><au>BÖHM, B. O</au><au>GALL, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clinical & Experimental Allergy</addtitle><date>1998-04</date><risdate>1998</risdate><volume>28</volume><issue>4</issue><spage>434</spage><epage>441</epage><pages>434-441</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Background
Allergenic crossreactivity of pollen and foods due to the antigeneic similarity of oligopeptides is a well established clinical phenomenon.
Objective
To determine the immunopathological relevance of antigen presentation, we analysed the HLA class‐II genotype of patients with either pollen allergy or pollen associated food allergy.
Methods
One hundred and twenty patients with pollen allergy and 80 patients with pollen associated food allergy were evaluated by skin‐ prick tests, RAST, and HLA class‐II genotyping. The control population comprised 4251 healthy blood and bone marrow donors.
Results
Monovalent pollen allergy was observed in 57% (n = 68) of patients with pollinosis (57x grass pollen, 11x birch pollen), but only in 15% (n = 12) of patients with food allergy (9x grass pollen, 3x birch pollen). Hazelnut (71%), almond (65%), walnut (44%) and apple (41%) were the most common food allergens and frequently associated with birch pollen allergy. Grass pollen allergy was associated with an increased frequency of HLA‐DQB1*0301 (RR = 2.3; EF = 0.4; P = 0.0016) when compared with the control population. HLA‐DRB1*08 confered a sixfold higher risk for peanut allergy (EF = 0.3; P = 0.0013) and ‐DRB1*12 a 13‐fold higher risk for carrot allergy (EF = 0.3; P < 0.000001). The differences on allele frequencies detected among patients with food allergies diminished or turned statistically insignificant when their genotypes were directly compared to those of patients with the corresponding pollen allergies. This was found in the case of birch pollen associated hazel nut allergy for the extended haplotype HLA‐DRB1*01, ‐DQA1*0101, ‐DQB1*0501 as well as in grass pollen associated peanut allergy for HLA‐DRB1*08 (from RR = 6, P = 0.0013 to insignificant) and in birch pollen associated carrot allergy for HLA‐DRB1*12 (from RR = 13, P < 0.000001 to insignificant).
Conclusion
We were able to identify HLA class‐II alleles associated with some allergies thus indicating that these alleles might confer susceptibility to the respective allergens. Similarities at the level of the HLA class‐II genotype parallel the empirical finding of distinct cross‐reactivity patterns thus complementing investigations of IgE specificities. Our observations provide evidence for the major importance of antigen presentation on the manifestation of distinct crossreactivity patterns.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>9641569</pmid><doi>10.1046/j.1365-2222.1998.00246.x</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 1998-04, Vol.28 (4), p.434-441 |
| issn | 0954-7894 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79962094 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alleles Allergens - adverse effects Allergens - immunology Allergic diseases allergy antigen presentation Biological and medical sciences carrot crossreactivity Daucus carota - immunology Disease Susceptibility - immunology Female food Food Hypersensitivity - epidemiology Food Hypersensitivity - etiology Food Hypersensitivity - immunology Genetic Predisposition to Disease Genotype grass HLA HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Immunopathology Male Medical sciences Other localizations peanut Poaceae - immunology pollen Pollen - adverse effects Pollen - immunology Radioallergosorbent Test Respiratory Hypersensitivity - epidemiology Respiratory Hypersensitivity - etiology Respiratory Hypersensitivity - immunology risk factor Skin Tests Time Factors Trees - chemistry Trees - immunology |
| title | Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy |
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