Caries in patients with non-insulin-dependent diabetes mellitus
Objective. The purpose of this study was to investigate the prevalence and risk factors of dental caries in patients with non-insulin-dependent diabetes mellitus and to determine whether these factors are associated with metabolic control and vascular complications of the disease. Study design. Both...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1998-06, Vol.85 (6), p.680-685 |
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| creator | Collin, Hanna-Leena Uusitupa, Matti Niskanen, Leo Koivisto, Anna-Maija Markkanen, Heleena Meurman, Jukka H |
| description | Objective.
The purpose of this study was to investigate the prevalence and risk factors of dental caries in patients with non-insulin-dependent diabetes mellitus and to determine whether these factors are associated with metabolic control and vascular complications of the disease.
Study design.
Both the occurrence of caries, acidogenic oral bacteria, and yeasts and salivary flow were studied in 25 patients with non-insulin-dependent diabetes mellitus whose diagnosis had been set 13 to 14 years earlier and in whom the metabolic evolution of the disease was well established. The patients' glycemic control was determined by means of analysis of the blood hemoglobin A
1C concentration at the time of dental examination. The control group consisted of 40 nondiabetic subjects in the same age group. Decayed, missing, and filled teeth indices and numbers of surfaces with caries, filled surfaces, and root caries were determined by means of clinical dental caries examination. Stimulated salivary flow was measured, and levels of
Streptococcus mutans, lactobacilli, and yeasts were analyzed.
Results.
The median hemoglobin A
1C concentration of the patients was 8.6%, which indicates poor metabolic control of diabetes. No association was found between the metabolic control of disease and dental caries. The occurrence of dental caries was not increased in the patients with non-insulin-dependent diabetes mellitus in comparison with the control subjects. The counts of acidogenic microbes and yeasts did not differ statistically significantly between the groups. There was no association of caries with the prevalence of coronary artery disease or hypertension in either the patients or the control subjects. In a stepwise logistic regression model, a salivary flow of at least 0.8 ml/min was related to the occurrence of dental caries in patients with non-insulin-dependent diabetes mellitus, whereas negligence with respect to dental care was the most important risk predictor in the control group.
Conclusion.
Our results showed no effect of diabetes on the prevalence of caries. However, the caries-protective effect of saliva was partly lost in patients with non-insulin-dependent diabetes mellitus. |
| doi_str_mv | 10.1016/S1079-2104(98)90035-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79959546</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S107921049890035X</els_id><sourcerecordid>79959546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-fbf34848b9dc608c69678df1e92d9baa7fbcb46cad9866def9c9e81a06f478483</originalsourceid><addsrcrecordid>eNqFkMtKBDEQRYMovj9hoBciumhN-pFOrUQGXzDgQoXZhXRSwUhPeky6Ff_ejDO6dZWCe26lOIRMGL1glPHLJ0YbyAtGqzMQ50BpWefzLbLP6kLkJdTz7TT_InvkIMY3SikvAXbJLvBSNJTtk6upCg5j5ny2VINDP8Ts0w2vme997nwcO-dzg0v0JmWZcarFIfEL7Do3jPGI7FjVRTzevIfk5fbmeXqfzx7vHqbXs1yXAobctrasRCVaMJpToTnwRhjLEAoDrVKNbXVbca0MCM4NWtCAginKbdWkXnlITtd7l6F_HzEOcuGiTkcoj_0YZQNQQ13xBNZrUIc-xoBWLoNbqPAlGZUrcfJHnFxZkSDkjzg5T73J5oOxXaD5a21Mpfxkk6uoVWeD8trFP6wogBcCEna1xjDJ-HAYZNTJqkbjAupBmt79c8g3EniLVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79959546</pqid></control><display><type>article</type><title>Caries in patients with non-insulin-dependent diabetes mellitus</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Collin, Hanna-Leena ; Uusitupa, Matti ; Niskanen, Leo ; Koivisto, Anna-Maija ; Markkanen, Heleena ; Meurman, Jukka H</creator><creatorcontrib>Collin, Hanna-Leena ; Uusitupa, Matti ; Niskanen, Leo ; Koivisto, Anna-Maija ; Markkanen, Heleena ; Meurman, Jukka H</creatorcontrib><description>Objective.
The purpose of this study was to investigate the prevalence and risk factors of dental caries in patients with non-insulin-dependent diabetes mellitus and to determine whether these factors are associated with metabolic control and vascular complications of the disease.
Study design.
Both the occurrence of caries, acidogenic oral bacteria, and yeasts and salivary flow were studied in 25 patients with non-insulin-dependent diabetes mellitus whose diagnosis had been set 13 to 14 years earlier and in whom the metabolic evolution of the disease was well established. The patients' glycemic control was determined by means of analysis of the blood hemoglobin A
1C concentration at the time of dental examination. The control group consisted of 40 nondiabetic subjects in the same age group. Decayed, missing, and filled teeth indices and numbers of surfaces with caries, filled surfaces, and root caries were determined by means of clinical dental caries examination. Stimulated salivary flow was measured, and levels of
Streptococcus mutans, lactobacilli, and yeasts were analyzed.
Results.
The median hemoglobin A
1C concentration of the patients was 8.6%, which indicates poor metabolic control of diabetes. No association was found between the metabolic control of disease and dental caries. The occurrence of dental caries was not increased in the patients with non-insulin-dependent diabetes mellitus in comparison with the control subjects. The counts of acidogenic microbes and yeasts did not differ statistically significantly between the groups. There was no association of caries with the prevalence of coronary artery disease or hypertension in either the patients or the control subjects. In a stepwise logistic regression model, a salivary flow of at least 0.8 ml/min was related to the occurrence of dental caries in patients with non-insulin-dependent diabetes mellitus, whereas negligence with respect to dental care was the most important risk predictor in the control group.
Conclusion.
Our results showed no effect of diabetes on the prevalence of caries. However, the caries-protective effect of saliva was partly lost in patients with non-insulin-dependent diabetes mellitus.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/S1079-2104(98)90035-X</identifier><identifier>PMID: 9638701</identifier><language>eng</language><publisher>St. Louis, MO: Mosby, Inc</publisher><subject>Aged ; Associated diseases and complications ; Biological and medical sciences ; Case-Control Studies ; Colony Count, Microbial ; Dental Caries - etiology ; Dentistry ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - therapy ; Diabetes. Impaired glucose tolerance ; DMF Index ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Lactobacillus - isolation & purification ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Saliva - metabolism ; Saliva - microbiology ; Secretory Rate ; Streptococcus mutans - isolation & purification</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1998-06, Vol.85 (6), p.680-685</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-fbf34848b9dc608c69678df1e92d9baa7fbcb46cad9866def9c9e81a06f478483</citedby><cites>FETCH-LOGICAL-c389t-fbf34848b9dc608c69678df1e92d9baa7fbcb46cad9866def9c9e81a06f478483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1079-2104(98)90035-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2296289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9638701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collin, Hanna-Leena</creatorcontrib><creatorcontrib>Uusitupa, Matti</creatorcontrib><creatorcontrib>Niskanen, Leo</creatorcontrib><creatorcontrib>Koivisto, Anna-Maija</creatorcontrib><creatorcontrib>Markkanen, Heleena</creatorcontrib><creatorcontrib>Meurman, Jukka H</creatorcontrib><title>Caries in patients with non-insulin-dependent diabetes mellitus</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective.
The purpose of this study was to investigate the prevalence and risk factors of dental caries in patients with non-insulin-dependent diabetes mellitus and to determine whether these factors are associated with metabolic control and vascular complications of the disease.
Study design.
Both the occurrence of caries, acidogenic oral bacteria, and yeasts and salivary flow were studied in 25 patients with non-insulin-dependent diabetes mellitus whose diagnosis had been set 13 to 14 years earlier and in whom the metabolic evolution of the disease was well established. The patients' glycemic control was determined by means of analysis of the blood hemoglobin A
1C concentration at the time of dental examination. The control group consisted of 40 nondiabetic subjects in the same age group. Decayed, missing, and filled teeth indices and numbers of surfaces with caries, filled surfaces, and root caries were determined by means of clinical dental caries examination. Stimulated salivary flow was measured, and levels of
Streptococcus mutans, lactobacilli, and yeasts were analyzed.
Results.
The median hemoglobin A
1C concentration of the patients was 8.6%, which indicates poor metabolic control of diabetes. No association was found between the metabolic control of disease and dental caries. The occurrence of dental caries was not increased in the patients with non-insulin-dependent diabetes mellitus in comparison with the control subjects. The counts of acidogenic microbes and yeasts did not differ statistically significantly between the groups. There was no association of caries with the prevalence of coronary artery disease or hypertension in either the patients or the control subjects. In a stepwise logistic regression model, a salivary flow of at least 0.8 ml/min was related to the occurrence of dental caries in patients with non-insulin-dependent diabetes mellitus, whereas negligence with respect to dental care was the most important risk predictor in the control group.
Conclusion.
Our results showed no effect of diabetes on the prevalence of caries. However, the caries-protective effect of saliva was partly lost in patients with non-insulin-dependent diabetes mellitus.</description><subject>Aged</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Colony Count, Microbial</subject><subject>Dental Caries - etiology</subject><subject>Dentistry</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DMF Index</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Lactobacillus - isolation & purification</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Saliva - metabolism</subject><subject>Saliva - microbiology</subject><subject>Secretory Rate</subject><subject>Streptococcus mutans - isolation & purification</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKBDEQRYMovj9hoBciumhN-pFOrUQGXzDgQoXZhXRSwUhPeky6Ff_ejDO6dZWCe26lOIRMGL1glPHLJ0YbyAtGqzMQ50BpWefzLbLP6kLkJdTz7TT_InvkIMY3SikvAXbJLvBSNJTtk6upCg5j5ny2VINDP8Ts0w2vme997nwcO-dzg0v0JmWZcarFIfEL7Do3jPGI7FjVRTzevIfk5fbmeXqfzx7vHqbXs1yXAobctrasRCVaMJpToTnwRhjLEAoDrVKNbXVbca0MCM4NWtCAginKbdWkXnlITtd7l6F_HzEOcuGiTkcoj_0YZQNQQ13xBNZrUIc-xoBWLoNbqPAlGZUrcfJHnFxZkSDkjzg5T73J5oOxXaD5a21Mpfxkk6uoVWeD8trFP6wogBcCEna1xjDJ-HAYZNTJqkbjAupBmt79c8g3EniLVA</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Collin, Hanna-Leena</creator><creator>Uusitupa, Matti</creator><creator>Niskanen, Leo</creator><creator>Koivisto, Anna-Maija</creator><creator>Markkanen, Heleena</creator><creator>Meurman, Jukka H</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Caries in patients with non-insulin-dependent diabetes mellitus</title><author>Collin, Hanna-Leena ; Uusitupa, Matti ; Niskanen, Leo ; Koivisto, Anna-Maija ; Markkanen, Heleena ; Meurman, Jukka H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-fbf34848b9dc608c69678df1e92d9baa7fbcb46cad9866def9c9e81a06f478483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Colony Count, Microbial</topic><topic>Dental Caries - etiology</topic><topic>Dentistry</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DMF Index</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Lactobacillus - isolation & purification</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Saliva - metabolism</topic><topic>Saliva - microbiology</topic><topic>Secretory Rate</topic><topic>Streptococcus mutans - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collin, Hanna-Leena</creatorcontrib><creatorcontrib>Uusitupa, Matti</creatorcontrib><creatorcontrib>Niskanen, Leo</creatorcontrib><creatorcontrib>Koivisto, Anna-Maija</creatorcontrib><creatorcontrib>Markkanen, Heleena</creatorcontrib><creatorcontrib>Meurman, Jukka H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collin, Hanna-Leena</au><au>Uusitupa, Matti</au><au>Niskanen, Leo</au><au>Koivisto, Anna-Maija</au><au>Markkanen, Heleena</au><au>Meurman, Jukka H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caries in patients with non-insulin-dependent diabetes mellitus</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>85</volume><issue>6</issue><spage>680</spage><epage>685</epage><pages>680-685</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective.
The purpose of this study was to investigate the prevalence and risk factors of dental caries in patients with non-insulin-dependent diabetes mellitus and to determine whether these factors are associated with metabolic control and vascular complications of the disease.
Study design.
Both the occurrence of caries, acidogenic oral bacteria, and yeasts and salivary flow were studied in 25 patients with non-insulin-dependent diabetes mellitus whose diagnosis had been set 13 to 14 years earlier and in whom the metabolic evolution of the disease was well established. The patients' glycemic control was determined by means of analysis of the blood hemoglobin A
1C concentration at the time of dental examination. The control group consisted of 40 nondiabetic subjects in the same age group. Decayed, missing, and filled teeth indices and numbers of surfaces with caries, filled surfaces, and root caries were determined by means of clinical dental caries examination. Stimulated salivary flow was measured, and levels of
Streptococcus mutans, lactobacilli, and yeasts were analyzed.
Results.
The median hemoglobin A
1C concentration of the patients was 8.6%, which indicates poor metabolic control of diabetes. No association was found between the metabolic control of disease and dental caries. The occurrence of dental caries was not increased in the patients with non-insulin-dependent diabetes mellitus in comparison with the control subjects. The counts of acidogenic microbes and yeasts did not differ statistically significantly between the groups. There was no association of caries with the prevalence of coronary artery disease or hypertension in either the patients or the control subjects. In a stepwise logistic regression model, a salivary flow of at least 0.8 ml/min was related to the occurrence of dental caries in patients with non-insulin-dependent diabetes mellitus, whereas negligence with respect to dental care was the most important risk predictor in the control group.
Conclusion.
Our results showed no effect of diabetes on the prevalence of caries. However, the caries-protective effect of saliva was partly lost in patients with non-insulin-dependent diabetes mellitus.</abstract><cop>St. Louis, MO</cop><pub>Mosby, Inc</pub><pmid>9638701</pmid><doi>10.1016/S1079-2104(98)90035-X</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1079-2104 |
| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 1998-06, Vol.85 (6), p.680-685 |
| issn | 1079-2104 1528-395X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79959546 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Associated diseases and complications Biological and medical sciences Case-Control Studies Colony Count, Microbial Dental Caries - etiology Dentistry Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - therapy Diabetes. Impaired glucose tolerance DMF Index Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Glycated Hemoglobin A - analysis Humans Lactobacillus - isolation & purification Logistic Models Male Medical sciences Middle Aged Saliva - metabolism Saliva - microbiology Secretory Rate Streptococcus mutans - isolation & purification |
| title | Caries in patients with non-insulin-dependent diabetes mellitus |
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