Characterization of a new strain of HHV-6 (HHV-6 SF) Recovered from the saliva of an HIV-infected individual
An isolate of the human herpesvirus-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual differs in its cellular host range and certain genomic properties from other HHV-6 strains described. HHV-6SF replicates in adult peripheral blood mononuclear cells (PMC) substantially better than...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1990-09, Vol.178 (1), p.113-121 |
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| container_title | Virology (New York, N.Y.) |
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| creator | Levy, Jay A. Ferro, Frank Lennette, Evelyne T. Oshiro, Lyndon Poulin, Louise |
| description | An isolate of the human herpesvirus-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual differs in its cellular host range and certain genomic properties from other HHV-6 strains described. HHV-6SF replicates in adult peripheral blood mononuclear cells (PMC) substantially better than in fetal cord blood PMC and can be grown only in the MT-4 established T cell line. It preferentially infects CD4+ lymphocytes but can replicate in CD8+ cells and peripheral blood macrophages. It also infects neuroblastoma cells and cell lines derived from the gastrointestinal tract. These latter results suggest that this herpesvirus could play a role in disorders affecting these tissues. Finally, the restriction enzyme pattern of HHV-6SF differs from that of other HHV-6 strains. The identification of this distinct HHV-6 strain could indicate an unusual biologic variation among viral isolates thus far not observed with other herpesviruses. |
| doi_str_mv | 10.1016/0042-6822(90)90384-4 |
| format | Article |
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HHV-6SF replicates in adult peripheral blood mononuclear cells (PMC) substantially better than in fetal cord blood PMC and can be grown only in the MT-4 established T cell line. It preferentially infects CD4+ lymphocytes but can replicate in CD8+ cells and peripheral blood macrophages. It also infects neuroblastoma cells and cell lines derived from the gastrointestinal tract. These latter results suggest that this herpesvirus could play a role in disorders affecting these tissues. Finally, the restriction enzyme pattern of HHV-6SF differs from that of other HHV-6 strains. The identification of this distinct HHV-6 strain could indicate an unusual biologic variation among viral isolates thus far not observed with other herpesviruses.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/0042-6822(90)90384-4</identifier><identifier>PMID: 1975142</identifier><identifier>CODEN: VIRLAX</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - microbiology ; AIDS/HIV ; Animals ; Antigens, Viral - analysis ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - microbiology ; CD4-Positive T-Lymphocytes - ultrastructure ; Cell Line ; Cytopathogenic Effect, Viral ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal Diseases - complications ; Gastrointestinal Diseases - microbiology ; Herpesviridae Infections - complications ; Herpesvirus 6, Human - classification ; Herpesvirus 6, Human - ultrastructure ; HIV Seropositivity - complications ; HIV Seropositivity - microbiology ; Humans ; Microbiology ; Neuroblastoma - etiology ; Neuroblastoma - microbiology ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Saliva - microbiology ; T-Lymphocytes, Regulatory - microbiology ; T-Lymphocytes, Regulatory - ultrastructure ; Virology ; Virus Replication</subject><ispartof>Virology (New York, N.Y.), 1990-09, Vol.178 (1), p.113-121</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-6d64c9ce15a8d4e56a0c3d16ef3e7d7cbff01a57f90a517a1f91ba55426595e93</citedby><cites>FETCH-LOGICAL-c418t-6d64c9ce15a8d4e56a0c3d16ef3e7d7cbff01a57f90a517a1f91ba55426595e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0042-6822(90)90384-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19526577$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1975142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levy, Jay A.</creatorcontrib><creatorcontrib>Ferro, Frank</creatorcontrib><creatorcontrib>Lennette, Evelyne T.</creatorcontrib><creatorcontrib>Oshiro, Lyndon</creatorcontrib><creatorcontrib>Poulin, Louise</creatorcontrib><title>Characterization of a new strain of HHV-6 (HHV-6 SF) Recovered from the saliva of an HIV-infected individual</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>An isolate of the human herpesvirus-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual differs in its cellular host range and certain genomic properties from other HHV-6 strains described. HHV-6SF replicates in adult peripheral blood mononuclear cells (PMC) substantially better than in fetal cord blood PMC and can be grown only in the MT-4 established T cell line. It preferentially infects CD4+ lymphocytes but can replicate in CD8+ cells and peripheral blood macrophages. It also infects neuroblastoma cells and cell lines derived from the gastrointestinal tract. These latter results suggest that this herpesvirus could play a role in disorders affecting these tissues. Finally, the restriction enzyme pattern of HHV-6SF differs from that of other HHV-6 strains. The identification of this distinct HHV-6 strain could indicate an unusual biologic variation among viral isolates thus far not observed with other herpesviruses.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - microbiology</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antigens, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - microbiology</subject><subject>CD4-Positive T-Lymphocytes - ultrastructure</subject><subject>Cell Line</subject><subject>Cytopathogenic Effect, Viral</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Diseases - complications</subject><subject>Gastrointestinal Diseases - microbiology</subject><subject>Herpesviridae Infections - complications</subject><subject>Herpesvirus 6, Human - classification</subject><subject>Herpesvirus 6, Human - ultrastructure</subject><subject>HIV Seropositivity - complications</subject><subject>HIV Seropositivity - microbiology</subject><subject>Humans</subject><subject>Microbiology</subject><subject>Neuroblastoma - etiology</subject><subject>Neuroblastoma - microbiology</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Saliva - microbiology</subject><subject>T-Lymphocytes, Regulatory - microbiology</subject><subject>T-Lymphocytes, Regulatory - ultrastructure</subject><subject>Virology</subject><subject>Virus Replication</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVpSdy0_6AFXVqSw7bSrj5Wl0AxTR0IFPJ1FWNpRBTWu4m0dml-fWSvaXtKT8Mwz7xIzxDygbMvnHH1lTFRV6qt62PDTgxrWlGJV2TGmVEVawR_TWZ_kEPyNud7Vnqt2QE54EZLLuoZ6eZ3kMCNmOITjHHo6RAo0B5_0TwmiLt-sbitFD2eytXZCb1EN2wwoachDSs63iHN0MUN7LZ7uji_rWIfsOR6GnsfN9GvoXtH3gToMr7f1yNyc_b9er6oLn7-OJ9_u6ic4O1YKa-EMw65hNYLlAqYazxXGBrUXrtlCIyD1MEwkFwDD4YvQUpRK2kkmuaIfJ5yH9LwuMY82lXMDrsOehzW2WpjZFuM_RfksuVto7aJYgJdGnJOGOxDiitIvy1ndnsNu1Vtt6qtYXZ3DSvK2sd9_nq5Qv93adJf5p_2c8gOupCgdzH_g8nyJa0LdzpxWKxtIiabXcTeoY-pSLZ-iC8_5BkuaaPK</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Levy, Jay A.</creator><creator>Ferro, Frank</creator><creator>Lennette, Evelyne T.</creator><creator>Oshiro, Lyndon</creator><creator>Poulin, Louise</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Characterization of a new strain of HHV-6 (HHV-6 SF) Recovered from the saliva of an HIV-infected individual</title><author>Levy, Jay A. ; Ferro, Frank ; Lennette, Evelyne T. ; Oshiro, Lyndon ; Poulin, Louise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-6d64c9ce15a8d4e56a0c3d16ef3e7d7cbff01a57f90a517a1f91ba55426595e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acquired Immunodeficiency Syndrome - microbiology</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antigens, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - microbiology</topic><topic>CD4-Positive T-Lymphocytes - ultrastructure</topic><topic>Cell Line</topic><topic>Cytopathogenic Effect, Viral</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Diseases - complications</topic><topic>Gastrointestinal Diseases - microbiology</topic><topic>Herpesviridae Infections - complications</topic><topic>Herpesvirus 6, Human - classification</topic><topic>Herpesvirus 6, Human - ultrastructure</topic><topic>HIV Seropositivity - complications</topic><topic>HIV Seropositivity - microbiology</topic><topic>Humans</topic><topic>Microbiology</topic><topic>Neuroblastoma - etiology</topic><topic>Neuroblastoma - microbiology</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Saliva - microbiology</topic><topic>T-Lymphocytes, Regulatory - microbiology</topic><topic>T-Lymphocytes, Regulatory - ultrastructure</topic><topic>Virology</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levy, Jay A.</creatorcontrib><creatorcontrib>Ferro, Frank</creatorcontrib><creatorcontrib>Lennette, Evelyne T.</creatorcontrib><creatorcontrib>Oshiro, Lyndon</creatorcontrib><creatorcontrib>Poulin, Louise</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levy, Jay A.</au><au>Ferro, Frank</au><au>Lennette, Evelyne T.</au><au>Oshiro, Lyndon</au><au>Poulin, Louise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of a new strain of HHV-6 (HHV-6 SF) Recovered from the saliva of an HIV-infected individual</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>178</volume><issue>1</issue><spage>113</spage><epage>121</epage><pages>113-121</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><coden>VIRLAX</coden><abstract>An isolate of the human herpesvirus-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual differs in its cellular host range and certain genomic properties from other HHV-6 strains described. HHV-6SF replicates in adult peripheral blood mononuclear cells (PMC) substantially better than in fetal cord blood PMC and can be grown only in the MT-4 established T cell line. It preferentially infects CD4+ lymphocytes but can replicate in CD8+ cells and peripheral blood macrophages. It also infects neuroblastoma cells and cell lines derived from the gastrointestinal tract. These latter results suggest that this herpesvirus could play a role in disorders affecting these tissues. Finally, the restriction enzyme pattern of HHV-6SF differs from that of other HHV-6 strains. The identification of this distinct HHV-6 strain could indicate an unusual biologic variation among viral isolates thus far not observed with other herpesviruses.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1975142</pmid><doi>10.1016/0042-6822(90)90384-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | Virology (New York, N.Y.), 1990-09, Vol.178 (1), p.113-121 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - microbiology AIDS/HIV Animals Antigens, Viral - analysis Biological and medical sciences CD4-Positive T-Lymphocytes - microbiology CD4-Positive T-Lymphocytes - ultrastructure Cell Line Cytopathogenic Effect, Viral Fundamental and applied biological sciences. Psychology Gastrointestinal Diseases - complications Gastrointestinal Diseases - microbiology Herpesviridae Infections - complications Herpesvirus 6, Human - classification Herpesvirus 6, Human - ultrastructure HIV Seropositivity - complications HIV Seropositivity - microbiology Humans Microbiology Neuroblastoma - etiology Neuroblastoma - microbiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Saliva - microbiology T-Lymphocytes, Regulatory - microbiology T-Lymphocytes, Regulatory - ultrastructure Virology Virus Replication |
| title | Characterization of a new strain of HHV-6 (HHV-6 SF) Recovered from the saliva of an HIV-infected individual |
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