Do leukocytes contribute to impaired microvascular tissue perfusion after arterial repair?
Impaired capillary perfusion may result in flap failure. Platelet emboli, polymorphonuclear leukocytes (PMNs), and/or vasospasm have been identified as possible causes. This study investigates the role of PMNs in causing impaired capillary perfusion in a free flap model. PMN concentrations were depl...
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| Veröffentlicht in: | Microsurgery 1998, Vol.18 (1), p.23-28 |
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| creator | Peter, Frank-W. Schuschke, Dale A. Wang, Wei Z. Anderson, Gary L. Franken, Ralph J.P.M. Pierangeli, Silvia Barker, John H. |
| description | Impaired capillary perfusion may result in flap failure. Platelet emboli, polymorphonuclear leukocytes (PMNs), and/or vasospasm have been identified as possible causes. This study investigates the role of PMNs in causing impaired capillary perfusion in a free flap model. PMN concentrations were depleted using antineutrophil serum. The cremaster muscles of 20 Sprague‐Dawley rats were isolated on a single neurovascular pedicle and after a simulated technically poor arterial anastomosis upstream and reperfusion, capillary perfusion was measured each hour for 6 hours. Even though the number of PMNs was significantly reduced in the animals treated with antineutrophil serum, capillary perfusion was not changed compared with controls. These results demonstrate that depleting circulating PMNs does not protect capillary perfusion in our model. These findings suggest that reduced capillary perfusion downstream from an anastomotic repair is not mediated by the presence of PMNs in the microcirculation. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:23–28, 1998. |
| doi_str_mv | 10.1002/(SICI)1098-2752(1998)18:1<23::AID-MICR6>3.0.CO;2-V |
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Platelet emboli, polymorphonuclear leukocytes (PMNs), and/or vasospasm have been identified as possible causes. This study investigates the role of PMNs in causing impaired capillary perfusion in a free flap model. PMN concentrations were depleted using antineutrophil serum. The cremaster muscles of 20 Sprague‐Dawley rats were isolated on a single neurovascular pedicle and after a simulated technically poor arterial anastomosis upstream and reperfusion, capillary perfusion was measured each hour for 6 hours. Even though the number of PMNs was significantly reduced in the animals treated with antineutrophil serum, capillary perfusion was not changed compared with controls. These results demonstrate that depleting circulating PMNs does not protect capillary perfusion in our model. These findings suggest that reduced capillary perfusion downstream from an anastomotic repair is not mediated by the presence of PMNs in the microcirculation. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:23–28, 1998.</description><identifier>ISSN: 0738-1085</identifier><identifier>EISSN: 1098-2752</identifier><identifier>DOI: 10.1002/(SICI)1098-2752(1998)18:1<23::AID-MICR6>3.0.CO;2-V</identifier><identifier>PMID: 9635790</identifier><identifier>CODEN: MSRGDQ</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Anastomosis, Surgical ; Animals ; Arteries - surgery ; Biological and medical sciences ; Capillaries - physiology ; Leukocytes, Mononuclear - physiology ; Male ; Medical sciences ; Microcirculation - physiology ; Rats ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Flaps - blood supply ; Time Factors ; Vascular surgery: aorta, extremities, vena cava. 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Platelet emboli, polymorphonuclear leukocytes (PMNs), and/or vasospasm have been identified as possible causes. This study investigates the role of PMNs in causing impaired capillary perfusion in a free flap model. PMN concentrations were depleted using antineutrophil serum. The cremaster muscles of 20 Sprague‐Dawley rats were isolated on a single neurovascular pedicle and after a simulated technically poor arterial anastomosis upstream and reperfusion, capillary perfusion was measured each hour for 6 hours. Even though the number of PMNs was significantly reduced in the animals treated with antineutrophil serum, capillary perfusion was not changed compared with controls. These results demonstrate that depleting circulating PMNs does not protect capillary perfusion in our model. These findings suggest that reduced capillary perfusion downstream from an anastomotic repair is not mediated by the presence of PMNs in the microcirculation. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:23–28, 1998.</description><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Arteries - surgery</subject><subject>Biological and medical sciences</subject><subject>Capillaries - physiology</subject><subject>Leukocytes, Mononuclear - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation - physiology</subject><subject>Rats</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Flaps - blood supply</subject><subject>Time Factors</subject><subject>Vascular surgery: aorta, extremities, vena cava. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical Flaps - blood supply</topic><topic>Time Factors</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peter, Frank-W.</creatorcontrib><creatorcontrib>Schuschke, Dale A.</creatorcontrib><creatorcontrib>Wang, Wei Z.</creatorcontrib><creatorcontrib>Anderson, Gary L.</creatorcontrib><creatorcontrib>Franken, Ralph J.P.M.</creatorcontrib><creatorcontrib>Pierangeli, Silvia</creatorcontrib><creatorcontrib>Barker, John H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peter, Frank-W.</au><au>Schuschke, Dale A.</au><au>Wang, Wei Z.</au><au>Anderson, Gary L.</au><au>Franken, Ralph J.P.M.</au><au>Pierangeli, Silvia</au><au>Barker, John H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do leukocytes contribute to impaired microvascular tissue perfusion after arterial repair?</atitle><jtitle>Microsurgery</jtitle><addtitle>Microsurgery</addtitle><date>1998</date><risdate>1998</risdate><volume>18</volume><issue>1</issue><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>0738-1085</issn><eissn>1098-2752</eissn><coden>MSRGDQ</coden><abstract>Impaired capillary perfusion may result in flap failure. Platelet emboli, polymorphonuclear leukocytes (PMNs), and/or vasospasm have been identified as possible causes. This study investigates the role of PMNs in causing impaired capillary perfusion in a free flap model. PMN concentrations were depleted using antineutrophil serum. The cremaster muscles of 20 Sprague‐Dawley rats were isolated on a single neurovascular pedicle and after a simulated technically poor arterial anastomosis upstream and reperfusion, capillary perfusion was measured each hour for 6 hours. Even though the number of PMNs was significantly reduced in the animals treated with antineutrophil serum, capillary perfusion was not changed compared with controls. These results demonstrate that depleting circulating PMNs does not protect capillary perfusion in our model. These findings suggest that reduced capillary perfusion downstream from an anastomotic repair is not mediated by the presence of PMNs in the microcirculation. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:23–28, 1998.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9635790</pmid><doi>10.1002/(SICI)1098-2752(1998)18:1<23::AID-MICR6>3.0.CO;2-V</doi><tpages>6</tpages></addata></record> |
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| subjects | Anastomosis, Surgical Animals Arteries - surgery Biological and medical sciences Capillaries - physiology Leukocytes, Mononuclear - physiology Male Medical sciences Microcirculation - physiology Rats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Flaps - blood supply Time Factors Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Do leukocytes contribute to impaired microvascular tissue perfusion after arterial repair? |
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