Changes in cochlear blood flow due to intra-arterial infusions of angiotensin II (3–8) (angiotensin IV) in guinea pigs
The effects of a newly discovered form of angiotensin, angiotensin IV (ANGIV), on cochlear blood flow (CBF) have been investigated utilizing the laser Doppler flowmetry (LDF) technique. Two specific questions were addressed: What are the effects of anterior inferior cerebellar artery infusions (AICA...
Gespeichert in:
| Veröffentlicht in: | Hearing research 1998-05, Vol.119 (1), p.61-68 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 68 |
|---|---|
| container_issue | 1 |
| container_start_page | 61 |
| container_title | Hearing research |
| container_volume | 119 |
| creator | Coleman, John K.M Lee, Janet I Miller, Josef M Nuttall, Alfred L |
| description | The effects of a newly discovered form of angiotensin, angiotensin IV (ANGIV), on cochlear blood flow (CBF) have been investigated utilizing the laser Doppler flowmetry (LDF) technique. Two specific questions were addressed: What are the effects of anterior inferior cerebellar artery infusions (AICA) of ANGIV on CBF and do angiotensin fragments other than ANGIV influence CBF in mature male and female guinea pigs. Infusions of ANGIV, and C-terminal shortened fragments were accomplished via micropipette into the AICA and changes in CBF were observed using LDF. The results demonstrated that 10 and 100 pmol/min doses of ANGIV increased CBF 22% and 75% (
n=6;
P |
| doi_str_mv | 10.1016/S0378-5955(98)00038-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79957526</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378595598000380</els_id><sourcerecordid>79957526</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-dbc8218deff23b0fee83f49e6a4a2aa300f0fee053adf5de83a2357ce5fee8363</originalsourceid><addsrcrecordid>eNqFkM1qGzEUhUVoSdy0jxDQIhR7MY00sjzSKhTTH0Ogi6bdimvpylEYjxxppj-7vkPfsE9SjW0MXXUldM8591w-Qq44e8MZX9x8ZqJRldRSTrWaMcaEqtgZmXA1jpXmz8jkZLkgL3J-ZIxLMa_PyblezLngekJ-LB-g22CmoaM22ocWIdF1G6Ojvo3fqRuQ9rGofYIKUo8pQFu-fsghdplGT0s-xB67XFasVnQq_vz6rWZ0-s_862xs2AyhQ6C7sMkvyXMPbcZXx_eSfHn_7n75sbr79GG1fHtXWaF0X7m1VTVXDr2vxZp5RCX8XOMC5lADCMb8OGRSgPPSFRVqIRuLcm9diEvy-rB3l-LTgLk325Atti10GIdsGq1lI-vRKA9Gm2LOCb3ZpbCF9NNwZkbiZk_cjDiNVmZP3LCSuzoWDOstulPqiLjo10cdsoXWJ-hsyCdbLUp7M9bfHmxYYHwLmEy2ATuLLiS0vXEx_OeQv_Zcnxw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79957526</pqid></control><display><type>article</type><title>Changes in cochlear blood flow due to intra-arterial infusions of angiotensin II (3–8) (angiotensin IV) in guinea pigs</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Coleman, John K.M ; Lee, Janet I ; Miller, Josef M ; Nuttall, Alfred L</creator><creatorcontrib>Coleman, John K.M ; Lee, Janet I ; Miller, Josef M ; Nuttall, Alfred L</creatorcontrib><description>The effects of a newly discovered form of angiotensin, angiotensin IV (ANGIV), on cochlear blood flow (CBF) have been investigated utilizing the laser Doppler flowmetry (LDF) technique. Two specific questions were addressed: What are the effects of anterior inferior cerebellar artery infusions (AICA) of ANGIV on CBF and do angiotensin fragments other than ANGIV influence CBF in mature male and female guinea pigs. Infusions of ANGIV, and C-terminal shortened fragments were accomplished via micropipette into the AICA and changes in CBF were observed using LDF. The results demonstrated that 10 and 100 pmol/min doses of ANGIV increased CBF 22% and 75% (
n=6;
P<0.01) from baseline, respectively, with little change in mean arterial blood pressure (MAP). Pretreatment with the ANGIV antagonist divalanal-ANGIV (1 nmole/min) blocked increases in CBF due to infusions of 100 pmol/min of ANGIV. The infusion of the C-terminal shortened fragment ANGIV(1–5) and saline had no significant effect on either CBF or MAP. These results provide the evidence for a new subtype of the angiotensin receptor and indicate the likely role of circulating hormones in blood flow regulation in the inner ear.</description><identifier>ISSN: 0378-5955</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/S0378-5955(98)00038-0</identifier><identifier>PMID: 9641319</identifier><identifier>CODEN: HERED3</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Angiotensin ; Angiotensin II - administration & dosage ; Angiotensin II - analogs & derivatives ; Angiotensin II - pharmacology ; Animals ; Biological and medical sciences ; Blood flow ; Blood Pressure - drug effects ; Cerebrovascular Circulation - drug effects ; Cochlea ; Cochlea - blood supply ; Cochlea - drug effects ; Dose-Response Relationship, Drug ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Female ; Fundamental and applied biological sciences. Psychology ; Guinea pig ; Guinea Pigs ; Hearing ; Infusions, Intra-Arterial ; Laser-Doppler Flowmetry ; Male ; Microcirculation ; Molecular Sequence Data ; Regional Blood Flow - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Hearing research, 1998-05, Vol.119 (1), p.61-68</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-dbc8218deff23b0fee83f49e6a4a2aa300f0fee053adf5de83a2357ce5fee8363</citedby><cites>FETCH-LOGICAL-c389t-dbc8218deff23b0fee83f49e6a4a2aa300f0fee053adf5de83a2357ce5fee8363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378595598000380$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2375276$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9641319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coleman, John K.M</creatorcontrib><creatorcontrib>Lee, Janet I</creatorcontrib><creatorcontrib>Miller, Josef M</creatorcontrib><creatorcontrib>Nuttall, Alfred L</creatorcontrib><title>Changes in cochlear blood flow due to intra-arterial infusions of angiotensin II (3–8) (angiotensin IV) in guinea pigs</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>The effects of a newly discovered form of angiotensin, angiotensin IV (ANGIV), on cochlear blood flow (CBF) have been investigated utilizing the laser Doppler flowmetry (LDF) technique. Two specific questions were addressed: What are the effects of anterior inferior cerebellar artery infusions (AICA) of ANGIV on CBF and do angiotensin fragments other than ANGIV influence CBF in mature male and female guinea pigs. Infusions of ANGIV, and C-terminal shortened fragments were accomplished via micropipette into the AICA and changes in CBF were observed using LDF. The results demonstrated that 10 and 100 pmol/min doses of ANGIV increased CBF 22% and 75% (
n=6;
P<0.01) from baseline, respectively, with little change in mean arterial blood pressure (MAP). Pretreatment with the ANGIV antagonist divalanal-ANGIV (1 nmole/min) blocked increases in CBF due to infusions of 100 pmol/min of ANGIV. The infusion of the C-terminal shortened fragment ANGIV(1–5) and saline had no significant effect on either CBF or MAP. These results provide the evidence for a new subtype of the angiotensin receptor and indicate the likely role of circulating hormones in blood flow regulation in the inner ear.</description><subject>Amino Acid Sequence</subject><subject>Angiotensin</subject><subject>Angiotensin II - administration & dosage</subject><subject>Angiotensin II - analogs & derivatives</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood flow</subject><subject>Blood Pressure - drug effects</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cochlea</subject><subject>Cochlea - blood supply</subject><subject>Cochlea - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea pig</subject><subject>Guinea Pigs</subject><subject>Hearing</subject><subject>Infusions, Intra-Arterial</subject><subject>Laser-Doppler Flowmetry</subject><subject>Male</subject><subject>Microcirculation</subject><subject>Molecular Sequence Data</subject><subject>Regional Blood Flow - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1qGzEUhUVoSdy0jxDQIhR7MY00sjzSKhTTH0Ogi6bdimvpylEYjxxppj-7vkPfsE9SjW0MXXUldM8591w-Qq44e8MZX9x8ZqJRldRSTrWaMcaEqtgZmXA1jpXmz8jkZLkgL3J-ZIxLMa_PyblezLngekJ-LB-g22CmoaM22ocWIdF1G6Ojvo3fqRuQ9rGofYIKUo8pQFu-fsghdplGT0s-xB67XFasVnQq_vz6rWZ0-s_862xs2AyhQ6C7sMkvyXMPbcZXx_eSfHn_7n75sbr79GG1fHtXWaF0X7m1VTVXDr2vxZp5RCX8XOMC5lADCMb8OGRSgPPSFRVqIRuLcm9diEvy-rB3l-LTgLk325Atti10GIdsGq1lI-vRKA9Gm2LOCb3ZpbCF9NNwZkbiZk_cjDiNVmZP3LCSuzoWDOstulPqiLjo10cdsoXWJ-hsyCdbLUp7M9bfHmxYYHwLmEy2ATuLLiS0vXEx_OeQv_Zcnxw</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Coleman, John K.M</creator><creator>Lee, Janet I</creator><creator>Miller, Josef M</creator><creator>Nuttall, Alfred L</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19980501</creationdate><title>Changes in cochlear blood flow due to intra-arterial infusions of angiotensin II (3–8) (angiotensin IV) in guinea pigs</title><author>Coleman, John K.M ; Lee, Janet I ; Miller, Josef M ; Nuttall, Alfred L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-dbc8218deff23b0fee83f49e6a4a2aa300f0fee053adf5de83a2357ce5fee8363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amino Acid Sequence</topic><topic>Angiotensin</topic><topic>Angiotensin II - administration & dosage</topic><topic>Angiotensin II - analogs & derivatives</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood flow</topic><topic>Blood Pressure - drug effects</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cochlea</topic><topic>Cochlea - blood supply</topic><topic>Cochlea - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea pig</topic><topic>Guinea Pigs</topic><topic>Hearing</topic><topic>Infusions, Intra-Arterial</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Microcirculation</topic><topic>Molecular Sequence Data</topic><topic>Regional Blood Flow - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coleman, John K.M</creatorcontrib><creatorcontrib>Lee, Janet I</creatorcontrib><creatorcontrib>Miller, Josef M</creatorcontrib><creatorcontrib>Nuttall, Alfred L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coleman, John K.M</au><au>Lee, Janet I</au><au>Miller, Josef M</au><au>Nuttall, Alfred L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in cochlear blood flow due to intra-arterial infusions of angiotensin II (3–8) (angiotensin IV) in guinea pigs</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>119</volume><issue>1</issue><spage>61</spage><epage>68</epage><pages>61-68</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>The effects of a newly discovered form of angiotensin, angiotensin IV (ANGIV), on cochlear blood flow (CBF) have been investigated utilizing the laser Doppler flowmetry (LDF) technique. Two specific questions were addressed: What are the effects of anterior inferior cerebellar artery infusions (AICA) of ANGIV on CBF and do angiotensin fragments other than ANGIV influence CBF in mature male and female guinea pigs. Infusions of ANGIV, and C-terminal shortened fragments were accomplished via micropipette into the AICA and changes in CBF were observed using LDF. The results demonstrated that 10 and 100 pmol/min doses of ANGIV increased CBF 22% and 75% (
n=6;
P<0.01) from baseline, respectively, with little change in mean arterial blood pressure (MAP). Pretreatment with the ANGIV antagonist divalanal-ANGIV (1 nmole/min) blocked increases in CBF due to infusions of 100 pmol/min of ANGIV. The infusion of the C-terminal shortened fragment ANGIV(1–5) and saline had no significant effect on either CBF or MAP. These results provide the evidence for a new subtype of the angiotensin receptor and indicate the likely role of circulating hormones in blood flow regulation in the inner ear.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9641319</pmid><doi>10.1016/S0378-5955(98)00038-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5955 |
| ispartof | Hearing research, 1998-05, Vol.119 (1), p.61-68 |
| issn | 0378-5955 1878-5891 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79957526 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Angiotensin Angiotensin II - administration & dosage Angiotensin II - analogs & derivatives Angiotensin II - pharmacology Animals Biological and medical sciences Blood flow Blood Pressure - drug effects Cerebrovascular Circulation - drug effects Cochlea Cochlea - blood supply Cochlea - drug effects Dose-Response Relationship, Drug Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Female Fundamental and applied biological sciences. Psychology Guinea pig Guinea Pigs Hearing Infusions, Intra-Arterial Laser-Doppler Flowmetry Male Microcirculation Molecular Sequence Data Regional Blood Flow - drug effects Vertebrates: nervous system and sense organs |
| title | Changes in cochlear blood flow due to intra-arterial infusions of angiotensin II (3–8) (angiotensin IV) in guinea pigs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T17%3A39%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20cochlear%20blood%20flow%20due%20to%20intra-arterial%20infusions%20of%20angiotensin%20II%20(3%E2%80%938)%20(angiotensin%20IV)%20in%20guinea%20pigs&rft.jtitle=Hearing%20research&rft.au=Coleman,%20John%20K.M&rft.date=1998-05-01&rft.volume=119&rft.issue=1&rft.spage=61&rft.epage=68&rft.pages=61-68&rft.issn=0378-5955&rft.eissn=1878-5891&rft.coden=HERED3&rft_id=info:doi/10.1016/S0378-5955(98)00038-0&rft_dat=%3Cproquest_cross%3E79957526%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79957526&rft_id=info:pmid/9641319&rft_els_id=S0378595598000380&rfr_iscdi=true |