Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis

The mechanism by which glucose stimulates insulin secretion from the pancreatic islets of Langerhans is incompletely understood. It has been suggested that malonyl-CoA plays a regulatory role by inhibiting fatty acid oxidation and promoting accumulation of cytosolic long-chain acyl-CoA (LC-CoA). In...

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Veröffentlicht in:	The Journal of biological chemistry 1998-06, Vol.273 (26), p.16146-16154
Hauptverfasser:	Antinozzi, P A, Segall, L, Prentki, M, McGarry, J D, Newgard, C B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism Animals Cells, Cultured Coenzyme A Ligases - antagonists & inhibitors Enzyme Inhibitors - pharmacology Glucose - metabolism Insulin - metabolism Insulin Secretion Lipid Metabolism Malonyl Coenzyme A - metabolism Palmitates - metabolism Rats Triazenes - pharmacology
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