Effect of vitamin B6 supplementation in McArdle's disease: a strategic case study
A patient-blind study into the effect of a 10-week cessation of long-term vitamin B6 supplementation on B6 status and performance in McArdle's disease is reported. Muscle performance was assessed both subjectively and objectively by an ischaemic fatiguing protocol of the adductor pollicis muscl...
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| Veröffentlicht in: | Neuromuscular disorders : NMD 1998-05, Vol.8 (3), p.210-212 |
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| container_title | Neuromuscular disorders : NMD |
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| creator | Phoenix, Joanne Hopkins, Pam Bartram, Clare Beynon, Robert J Quinlivan, Rosaline C.M Edwards, Richard H.T |
| description | A patient-blind study into the effect of a 10-week cessation of long-term vitamin B6 supplementation on B6 status and performance in McArdle's disease is reported. Muscle performance was assessed both subjectively and objectively by an ischaemic fatiguing protocol of the adductor pollicis muscle. Nine weeks after withdrawal of supplementation, vitamin B6 status had changed from adequacy to inadequacy and the force loss during the ischaemic fatiguing protocol had increased at all frequencies studied. The patient reported decreased exercise tolerance after 7 weeks and by the tenth week was experiencing an increase in muscle cramps. Vitamin B6 status and muscle performance may be linked in McArdle's disease and there is potential for enhancement of performance by B6 supplementation. |
| doi_str_mv | 10.1016/S0960-8966(98)00004-2 |
| format | Article |
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Muscle performance was assessed both subjectively and objectively by an ischaemic fatiguing protocol of the adductor pollicis muscle. Nine weeks after withdrawal of supplementation, vitamin B6 status had changed from adequacy to inadequacy and the force loss during the ischaemic fatiguing protocol had increased at all frequencies studied. The patient reported decreased exercise tolerance after 7 weeks and by the tenth week was experiencing an increase in muscle cramps. 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Muscle performance was assessed both subjectively and objectively by an ischaemic fatiguing protocol of the adductor pollicis muscle. Nine weeks after withdrawal of supplementation, vitamin B6 status had changed from adequacy to inadequacy and the force loss during the ischaemic fatiguing protocol had increased at all frequencies studied. The patient reported decreased exercise tolerance after 7 weeks and by the tenth week was experiencing an increase in muscle cramps. Vitamin B6 status and muscle performance may be linked in McArdle's disease and there is potential for enhancement of performance by B6 supplementation.</description><subject>Dietary Supplements</subject><subject>Exercise</subject><subject>Glycogen Storage Disease Type V - complications</subject><subject>Glycogen Storage Disease Type V - drug therapy</subject><subject>Glycogen Storage Disease Type V - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>McArdle's disease</subject><subject>Middle Aged</subject><subject>Muscle Cramp - etiology</subject><subject>Muscle Cramp - physiopathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Myophosphorylase deficiency</subject><subject>Physical Endurance - physiology</subject><subject>Pyridoxine</subject><subject>Pyridoxine - administration & dosage</subject><subject>Pyridoxine - therapeutic use</subject><subject>Therapy</subject><subject>Vitamin B6</subject><issn>0960-8966</issn><issn>1873-2364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMo47g8wkBOLofWpDudTrzIKG6giKjnkE4qEullTLoF397MglfrUlTVX9uH0IySM0ooP38lkpNMSM5PpDglyViWb6EpFVWR5QVn22j6J9lFezF-EkLLilcTNJG8oIywKXq5cQ7MgHuHv_2gW9_hK47juFg00EI36MH3HU7ZJzMPtoHjiK2PoCNcYI3jEPQAH95gkzIpHO3PAdpxuolwuPH76P325u36Pnt8vnu4nj9mhuV8yJyguWagSyFoWWvQzOWkqo3La0MFT5cKawvLmKwryAWxxGgjiGRO07J0vNhHR-u5i9B_jRAH1fpooGl0B_0YVSUlExUlSViuhSb0MQZwahF8q8OPokQtUaoVSrXkpKRQK5QqT32zzYKxbsH-dW3Ypfrlug7py28PQUXjoTNgfUhIle39Pxt-Aanrgv0</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Phoenix, Joanne</creator><creator>Hopkins, Pam</creator><creator>Bartram, Clare</creator><creator>Beynon, Robert J</creator><creator>Quinlivan, Rosaline C.M</creator><creator>Edwards, Richard H.T</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980501</creationdate><title>Effect of vitamin B6 supplementation in McArdle's disease: a strategic case study</title><author>Phoenix, Joanne ; Hopkins, Pam ; Bartram, Clare ; Beynon, Robert J ; Quinlivan, Rosaline C.M ; Edwards, Richard H.T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-f812a4ea58815baea4f207bcf2bc1860158dd3d449b7e280d0cac8094fa155f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Dietary Supplements</topic><topic>Exercise</topic><topic>Glycogen Storage Disease Type V - complications</topic><topic>Glycogen Storage Disease Type V - drug therapy</topic><topic>Glycogen Storage Disease Type V - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>McArdle's disease</topic><topic>Middle Aged</topic><topic>Muscle Cramp - etiology</topic><topic>Muscle Cramp - physiopathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Myophosphorylase deficiency</topic><topic>Physical Endurance - physiology</topic><topic>Pyridoxine</topic><topic>Pyridoxine - administration & dosage</topic><topic>Pyridoxine - therapeutic use</topic><topic>Therapy</topic><topic>Vitamin B6</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phoenix, Joanne</creatorcontrib><creatorcontrib>Hopkins, Pam</creatorcontrib><creatorcontrib>Bartram, Clare</creatorcontrib><creatorcontrib>Beynon, Robert J</creatorcontrib><creatorcontrib>Quinlivan, Rosaline C.M</creatorcontrib><creatorcontrib>Edwards, Richard H.T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuromuscular disorders : NMD</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phoenix, Joanne</au><au>Hopkins, Pam</au><au>Bartram, Clare</au><au>Beynon, Robert J</au><au>Quinlivan, Rosaline C.M</au><au>Edwards, Richard H.T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin B6 supplementation in McArdle's disease: a strategic case study</atitle><jtitle>Neuromuscular disorders : NMD</jtitle><addtitle>Neuromuscul Disord</addtitle><date>1998-05-01</date><risdate>1998</risdate><volume>8</volume><issue>3</issue><spage>210</spage><epage>212</epage><pages>210-212</pages><issn>0960-8966</issn><eissn>1873-2364</eissn><abstract>A patient-blind study into the effect of a 10-week cessation of long-term vitamin B6 supplementation on B6 status and performance in McArdle's disease is reported. Muscle performance was assessed both subjectively and objectively by an ischaemic fatiguing protocol of the adductor pollicis muscle. Nine weeks after withdrawal of supplementation, vitamin B6 status had changed from adequacy to inadequacy and the force loss during the ischaemic fatiguing protocol had increased at all frequencies studied. The patient reported decreased exercise tolerance after 7 weeks and by the tenth week was experiencing an increase in muscle cramps. Vitamin B6 status and muscle performance may be linked in McArdle's disease and there is potential for enhancement of performance by B6 supplementation.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>9631404</pmid><doi>10.1016/S0960-8966(98)00004-2</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-8966 |
| ispartof | Neuromuscular disorders : NMD, 1998-05, Vol.8 (3), p.210-212 |
| issn | 0960-8966 1873-2364 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Dietary Supplements Exercise Glycogen Storage Disease Type V - complications Glycogen Storage Disease Type V - drug therapy Glycogen Storage Disease Type V - physiopathology Humans Male McArdle's disease Middle Aged Muscle Cramp - etiology Muscle Cramp - physiopathology Muscle, Skeletal - physiopathology Myophosphorylase deficiency Physical Endurance - physiology Pyridoxine Pyridoxine - administration & dosage Pyridoxine - therapeutic use Therapy Vitamin B6 |
| title | Effect of vitamin B6 supplementation in McArdle's disease: a strategic case study |
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