Serotonin Subtype 2 Receptor Genes and Clinical Response to Clozapine in Schizophrenia Patients

Using a pharmacogenetic approach in 185 schizophrenics who have been prospectively assessed for clozapine response, we have examined the hypothesis that polymorphisms in the 5-HT2A (HTR2A), and 5-HT2C (HTR2C) genes are involved in its variable response. A -1438 A→ G polymorphism in the putative prom...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 1998-08, Vol.19 (2), p.123-132
Hauptverfasser:	Masellis, Mario, Basile, Vincenzo, Meltzer, Herbert Y., Lieberman, Jeffrey A., Sevy, Serge, Macciardi, Fabio M., Cola, Phil, Howard, Alfreda, Badri, Farideh, Nöthen, Markus M., Kalow, Werner, Kennedy, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT2A 5-HT2C Adult Analysis of Variance Antipsychotic Agents - therapeutic use Biological and medical sciences Black or African American Black People - genetics Clozapine - therapeutic use Clozapine response DNA - blood Female Gene Frequency Genotype Haplotypes Humans Linkage Disequilibrium Male Medical sciences Neuropharmacology North America Pharmacogenetic Pharmacology. Drug treatments Point Mutation Polymorphism Polymorphism, Genetic Promoter Regions, Genetic Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptor Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C Receptors, Serotonin - genetics Schizophrenia - drug therapy Schizophrenia - genetics White People - genetics
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