Cyclosporin a exerts a cytostatic effect in vivo on human and murine epithelial cells

Cyclosporin A (CsA) is a potent immunosuppressant that may also affect nonlymphoid cells. Indeed, CsA exerts a growth inhibition in vitro of several human and animal, normal and neoplastic cell types. To assess a possible in vivo direct cytostatic activity of CsA, the authors evaluated the proportio...

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Veröffentlicht in:Cancer 1990-09, Vol.66 (5), p.936-940
Hauptverfasser: Ramirez‐Bosca, Ana, Kanitakis, Jean, Thivolet, Jean
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container_title Cancer
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creator Ramirez‐Bosca, Ana
Kanitakis, Jean
Thivolet, Jean
description Cyclosporin A (CsA) is a potent immunosuppressant that may also affect nonlymphoid cells. Indeed, CsA exerts a growth inhibition in vitro of several human and animal, normal and neoplastic cell types. To assess a possible in vivo direct cytostatic activity of CsA, the authors evaluated the proportion of S‐phase (5‐bromo‐2′‐deoxyuridine incorporating) cells of epithelial origin (skin, tongue, esophagus) of congenitally athymic (nude) mice bearing xenografts of human skin and receiving a daily subcutaneous injection of 50 mg/kg of CsA for 3 weeks. As compared with control animals, CsA‐treated mice showed a decreased labeling index (LI) of all the epithelial tissues studied, which was statistically significant in the case of epidermis (both human and murine) and the tongue. Because nude mice lack T‐cell‐mediated immunity, these results suggest that CsA also exerts an immunologically independent antiproliferative activity on epithelial cells in vivo and they also highlight the interest in pursuing studies on cyclosporins as cytostatic agents.
doi_str_mv 10.1002/1097-0142(19900901)66:5<936::AID-CNCR2820660521>3.0.CO;2-0
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subjects Animals
Cell Division - drug effects
Cyclosporins - blood
Cyclosporins - pharmacology
Epithelial Cells
Female
Humans
Keratinocytes - cytology
Mice
Mice, Nude
Skin - cytology
title Cyclosporin a exerts a cytostatic effect in vivo on human and murine epithelial cells
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