Differential regulation of cyclooxygenases 1 and 2 by interleukin-1 beta, tumor necrosis factor-alpha, and transforming growth factor-beta 1 in human lung fibroblasts

In the present studies we found that incubation of human lung fibroblasts with transforming growth factor-beta 1 (TGF-beta 1) potentiated the interleukin-1 beta (IL-1 beta) and/or tumor necrosis factor-alpha (TNF-alpha)-stimulated production of prostaglandin E2 (PGE2). Analysis of fibroblast protein...

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Veröffentlicht in:	Experimental cell research 1998-05, Vol.241 (1), p.222-229
Hauptverfasser:	Diaz, A, Chepenik, K P, Korn, J H, Reginato, A M, Jimenez, S A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cyclooxygenase 1 Cyclooxygenase 2 Dinoprostone - metabolism Female Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - enzymology Gene Expression Regulation, Enzymologic Humans Interleukin-1 - pharmacology Isoenzymes - drug effects Isoenzymes - genetics Lung - cytology Lung - drug effects Lung - enzymology Membrane Proteins Middle Aged Prostaglandin-Endoperoxide Synthases - drug effects Prostaglandin-Endoperoxide Synthases - genetics RNA, Messenger - drug effects RNA, Messenger - metabolism Transcription, Genetic - drug effects Transcription, Genetic - genetics Transforming Growth Factor beta - pharmacology Tumor Necrosis Factor-alpha - pharmacology
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