On the fundamental difference in the thermodynamics of agonist and antagonist interactions with β-adrenergic receptors and the mechanism of entropy-driven binding

Several investigations point to a fundamental difference between the molecular interactions of agonists and antagonists with the beta -adrenergic receptor. Whereas beta -agonists bind with large decreases in enthalpy and entropy, the binding of beta -antagonists is characterized by a small change of...

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Veröffentlicht in:Biochemical pharmacology 1990-08, Vol.40 (4), p.663-669
Hauptverfasser: Miklavc, Adolf, Kocjan, Darko, Mavri, Jonez, Koller, Jože, Hadži, Dušan
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Sprache:eng
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