On the fundamental difference in the thermodynamics of agonist and antagonist interactions with β-adrenergic receptors and the mechanism of entropy-driven binding
Several investigations point to a fundamental difference between the molecular interactions of agonists and antagonists with the beta -adrenergic receptor. Whereas beta -agonists bind with large decreases in enthalpy and entropy, the binding of beta -antagonists is characterized by a small change of...
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Veröffentlicht in: | Biochemical pharmacology 1990-08, Vol.40 (4), p.663-669 |
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Format: | Artikel |
Sprache: | eng |
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