The Selective Estrogen Receptor Modulator, Raloxifene: Reproductive Assessments following Premating Exposure in Female Rats

Raloxifene HCl is a nonsteroidal, selective estrogen receptor modulator developed as a therapeutic agent for postmenopausal osteoporosis. Two studies were conducted that examined the effects of premating exposure to raloxifene HCl. In the first study, adult female CD ® rats (20/group) were given die...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1998-05, Vol.12 (3), p.233-245
Hauptverfasser:	Hoyt, Judith A, Fisher, Lawrence F, Buelke-Sam, Judy L, Francis, Paul C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals antifertility Biological and medical sciences Drug toxicity and drugs side effects treatment Estrogen Antagonists - pharmacology estrous cycles Estrus - drug effects Evaluation Studies as Topic Female Gestational Age Male Medical sciences Pharmacology. Drug treatments Piperidines - pharmacology Pregnancy premating effects progeny effects raloxifene Raloxifene Hydrochloride rat Rats Receptors, Estrogen - agonists Receptors, Estrogen - drug effects reproduction Reproduction - drug effects SERM Sexual Behavior, Animal Toxicity: urogenital system
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