Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes

Objective To determine whether genetic polymorphism of cytochrome P450 (CYP) 2C9 or 2C19 affects the in vivo metabolism of warfarin enantiomers. Methods Eighty‐six Japanese patients heart disease who were given warfarin participated in the study. Plasma unbound concentrations of warfarin enantiomers...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical pharmacology and therapeutics 1998-05, Vol.63 (5), p.519-528
Hauptverfasser:	Takahashi, Harumi, Kashima, Toshitaka, Nomizo, Yuko, Muramoto, Nagisa, Shimizu, Teppei, Nasu, Kayoko, Kubota, Takahiro, Kimura, Sosuke, Echizen, Hirotoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anticoagulants - blood Anticoagulants - metabolism Anticoagulants - pharmacokinetics Aryl Hydrocarbon Hydroxylases Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme System - genetics Female Genotype Heart Diseases - genetics Heart Diseases - metabolism Humans Japan Male Medical sciences Metabolic Clearance Rate Middle Aged Mixed Function Oxygenases - genetics Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism, Genetic Stereoisomerism Steroid 16-alpha-Hydroxylase Steroid Hydroxylases - genetics Warfarin - blood Warfarin - metabolism Warfarin - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!