Androgen regulation of polyamine synthesis in seminal vesicle and in different lobes of the rat prostate
Endogenous levels of the polyamines putrescine, spermidine, and spermine have been examined in the 106 m/s2 supernatant of different lobes of the rat prostate and in the seminal vesicles of castrates, androgen‐stimulated castrates, and intact controls. Content of the polyamines varied between the lo...
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| Veröffentlicht in: | The Prostate 1990, Vol.17 (1), p.1-11 |
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| creator | Fjösne, Hans E. Östensen, Mari-Ann Haarstad, Helge Sunde, Arne |
| description | Endogenous levels of the polyamines putrescine, spermidine, and spermine have been examined in the 106 m/s2 supernatant of different lobes of the rat prostate and in the seminal vesicles of castrates, androgen‐stimulated castrates, and intact controls.
Content of the polyamines varied between the lobes, with spermidine highest in intact animals. After castration, the content of polyamines fell significantly in all lobes but the coagulating gland (CG). Spermidine levels were highest, except in the lateral prostate (LP) and CG, where the content of putrescine was highest. In castrated animals treated with testosterone propionate for 72 h, the amount of the three polyamines examined increased dramatically in the ventral prostate (VP) and moderately in the CG and seminal vesicle (SV). Concerning individual polyamines, spermidine increased significantly in all lobes, while putrescine increased significantly only in the two saccular parts of rat prostate, i.e., CG and SV. Spermidine content decreased significantly in the DP.
Major differences in the content of the three polyamines—putrescine, spermidine, and spermine—in the various tissues studied have been found. Moreover, distinct differences among intact, castrated, and testosterone‐treated castrated animals have been revealed. |
| doi_str_mv | 10.1002/pros.2990170102 |
| format | Article |
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Content of the polyamines varied between the lobes, with spermidine highest in intact animals. After castration, the content of polyamines fell significantly in all lobes but the coagulating gland (CG). Spermidine levels were highest, except in the lateral prostate (LP) and CG, where the content of putrescine was highest. In castrated animals treated with testosterone propionate for 72 h, the amount of the three polyamines examined increased dramatically in the ventral prostate (VP) and moderately in the CG and seminal vesicle (SV). Concerning individual polyamines, spermidine increased significantly in all lobes, while putrescine increased significantly only in the two saccular parts of rat prostate, i.e., CG and SV. Spermidine content decreased significantly in the DP.
Major differences in the content of the three polyamines—putrescine, spermidine, and spermine—in the various tissues studied have been found. Moreover, distinct differences among intact, castrated, and testosterone‐treated castrated animals have been revealed.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.2990170102</identifier><identifier>PMID: 2385548</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; castration ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Orchiectomy ; polyamines ; Polyamines - metabolism ; prostate ; Prostate - drug effects ; Prostate - metabolism ; Putrescine - biosynthesis ; rat ; Rats ; Rats, Inbred Strains ; Seminal Vesicles - drug effects ; Seminal Vesicles - metabolism ; Spermidine - biosynthesis ; Spermine - biosynthesis ; stimulation ; Testosterone - pharmacology ; Time Factors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>The Prostate, 1990, Vol.17 (1), p.1-11</ispartof><rights>Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4122-c150283367faddfa7c6ed7e686d8272611f227774fc9b168c560e45d7df973253</citedby><cites>FETCH-LOGICAL-c4122-c150283367faddfa7c6ed7e686d8272611f227774fc9b168c560e45d7df973253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.2990170102$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.2990170102$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4009,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19412500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2385548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fjösne, Hans E.</creatorcontrib><creatorcontrib>Östensen, Mari-Ann</creatorcontrib><creatorcontrib>Haarstad, Helge</creatorcontrib><creatorcontrib>Sunde, Arne</creatorcontrib><title>Androgen regulation of polyamine synthesis in seminal vesicle and in different lobes of the rat prostate</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>Endogenous levels of the polyamines putrescine, spermidine, and spermine have been examined in the 106 m/s2 supernatant of different lobes of the rat prostate and in the seminal vesicles of castrates, androgen‐stimulated castrates, and intact controls.
Content of the polyamines varied between the lobes, with spermidine highest in intact animals. After castration, the content of polyamines fell significantly in all lobes but the coagulating gland (CG). Spermidine levels were highest, except in the lateral prostate (LP) and CG, where the content of putrescine was highest. In castrated animals treated with testosterone propionate for 72 h, the amount of the three polyamines examined increased dramatically in the ventral prostate (VP) and moderately in the CG and seminal vesicle (SV). Concerning individual polyamines, spermidine increased significantly in all lobes, while putrescine increased significantly only in the two saccular parts of rat prostate, i.e., CG and SV. Spermidine content decreased significantly in the DP.
Major differences in the content of the three polyamines—putrescine, spermidine, and spermine—in the various tissues studied have been found. Moreover, distinct differences among intact, castrated, and testosterone‐treated castrated animals have been revealed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>castration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Orchiectomy</subject><subject>polyamines</subject><subject>Polyamines - metabolism</subject><subject>prostate</subject><subject>Prostate - drug effects</subject><subject>Prostate - metabolism</subject><subject>Putrescine - biosynthesis</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Seminal Vesicles - drug effects</subject><subject>Seminal Vesicles - metabolism</subject><subject>Spermidine - biosynthesis</subject><subject>Spermine - biosynthesis</subject><subject>stimulation</subject><subject>Testosterone - pharmacology</subject><subject>Time Factors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1PVDEUxRujwQFduzLpRnYP-vH6-l5cEQIoTETlQ3dNp72FaqdvaN8o89_Tl5lAWLFqcu7vnHt6EfpAyR4lhO0vUp_3WNcRKgkl7BWaUNLJipBavEYTwiSpasrlW7Sd8x9SkGLaQluMt0LU7QTdHkSb-huIOMHNMujB9xH3Di_6sNJzHwHnVRxuIfuMfcQZiqYD_lcEEwDraEfZeucgQRxw6GeQx4DiwUkPeCw46AHeoTdOhwzvN-8Oujo-ujz8Uk3PT74eHkwrU1PGKkMFYS3njXTaWqelacBKaNrGtkyyhlLHmJSydqab0aY1oiFQCyut6yRngu-g3XVuWXy3hDyouc8GQtAR-mVWsuvquiQUcH8NmtIwJ3Bqkfxcp5WiRI23VWN19XTb4vi4iV7O5mAf-c0xy_zTZq6z0cElHY3PT7Fd-aEgpHCf19x_H2D10lr1_ef5xbMW1drt8wD3j26d_qpGcinUr28niv-4PDu9_n2hpvwBevaj1A</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Fjösne, Hans E.</creator><creator>Östensen, Mari-Ann</creator><creator>Haarstad, Helge</creator><creator>Sunde, Arne</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Androgen regulation of polyamine synthesis in seminal vesicle and in different lobes of the rat prostate</title><author>Fjösne, Hans E. ; Östensen, Mari-Ann ; Haarstad, Helge ; Sunde, Arne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4122-c150283367faddfa7c6ed7e686d8272611f227774fc9b168c560e45d7df973253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>castration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Orchiectomy</topic><topic>polyamines</topic><topic>Polyamines - metabolism</topic><topic>prostate</topic><topic>Prostate - drug effects</topic><topic>Prostate - metabolism</topic><topic>Putrescine - biosynthesis</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Seminal Vesicles - drug effects</topic><topic>Seminal Vesicles - metabolism</topic><topic>Spermidine - biosynthesis</topic><topic>Spermine - biosynthesis</topic><topic>stimulation</topic><topic>Testosterone - pharmacology</topic><topic>Time Factors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fjösne, Hans E.</creatorcontrib><creatorcontrib>Östensen, Mari-Ann</creatorcontrib><creatorcontrib>Haarstad, Helge</creatorcontrib><creatorcontrib>Sunde, Arne</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fjösne, Hans E.</au><au>Östensen, Mari-Ann</au><au>Haarstad, Helge</au><au>Sunde, Arne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Androgen regulation of polyamine synthesis in seminal vesicle and in different lobes of the rat prostate</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>1990</date><risdate>1990</risdate><volume>17</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>Endogenous levels of the polyamines putrescine, spermidine, and spermine have been examined in the 106 m/s2 supernatant of different lobes of the rat prostate and in the seminal vesicles of castrates, androgen‐stimulated castrates, and intact controls.
Content of the polyamines varied between the lobes, with spermidine highest in intact animals. After castration, the content of polyamines fell significantly in all lobes but the coagulating gland (CG). Spermidine levels were highest, except in the lateral prostate (LP) and CG, where the content of putrescine was highest. In castrated animals treated with testosterone propionate for 72 h, the amount of the three polyamines examined increased dramatically in the ventral prostate (VP) and moderately in the CG and seminal vesicle (SV). Concerning individual polyamines, spermidine increased significantly in all lobes, while putrescine increased significantly only in the two saccular parts of rat prostate, i.e., CG and SV. Spermidine content decreased significantly in the DP.
Major differences in the content of the three polyamines—putrescine, spermidine, and spermine—in the various tissues studied have been found. Moreover, distinct differences among intact, castrated, and testosterone‐treated castrated animals have been revealed.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2385548</pmid><doi>10.1002/pros.2990170102</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences castration Male Medical sciences Nephrology. Urinary tract diseases Orchiectomy polyamines Polyamines - metabolism prostate Prostate - drug effects Prostate - metabolism Putrescine - biosynthesis rat Rats Rats, Inbred Strains Seminal Vesicles - drug effects Seminal Vesicles - metabolism Spermidine - biosynthesis Spermine - biosynthesis stimulation Testosterone - pharmacology Time Factors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Androgen regulation of polyamine synthesis in seminal vesicle and in different lobes of the rat prostate |
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