The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices
HYPOXIA-INDUCED changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen t...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 1998-05, Vol.9 (7), p.1419-1423 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1423 |
|---|---|
| container_issue | 7 |
| container_start_page | 1419 |
| container_title | Neuroreport |
| container_volume | 9 |
| creator | Staunton, Michael Dulitz, Michael G Fang, Celia Schmeling, William T Kampine, John P Farber, Neil E |
| description | HYPOXIA-INDUCED changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was maintained at 500 mmHg. In groups 2 and 3, PO2 was gradually reduced to anoxia (95% N2/5% CO2). In group 3, prostaglandin F2aα was given to approximate physiological myogenic tone. PCO2 and pH were controlled. Graded hypoxia progressively dilated vessels (PO2 300 mmHg = 2.4±1.2%, 4.2 ± 1.6%; PO2 90 mHg= 15.4 ± 3.0%, 14.5 ± 1.8%; groups 2 and 3, respectively). The presence of preconstriction did not influence the extent of hypoxia-induced dilation. This vasorelaxation may be important in maintaining cerebral oxygen delivery during microvascular hypoxia. |
| doi_str_mv | 10.1097/00001756-199805110-00031 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79943558</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79943558</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4151-20b8f3e5ef30044c941a73da01bbc90bb81416d49f694e941fed2f009f7439873</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi1U1G5bfgKSD6i3gCd2PuaIKgpIleBQJG7WxBmTgDfZ2lmV_fd1u9u9IXyx5feZGeuxEBLUe1DYfFB5QVPVBSC2qgJQRb7R8EqswDS6qKr254lYKaywMFhXZ-I8pd8ZQQXtqTjFWoMxaiW-3w0s2Xt2S5Kzl78i9dzLYbeZ_44k50mO0xJpQ5EnN-zWFCTFheM4B045k5EW2UXKpxRGx-lSvPYUEr857Bfix82nu-svxe23z1-vP94WzkAFRam61muu2GuljHFogBrdk4Kuc6i6rgUDdW_Q12g4p5770uf3-8ZobBt9Ia72fTdxvt9yWux6TI5DoInnbbINotFZw39BqE1T1s8d2z3o4pxSZG83cVxT3FlQ9sm6fbFuj9bts_Vc-vYwY9utuT8WHjTn_N0hp-Qo-EiTG9MRK0uDCJgxs8ce5pAdpz9h-8DRDkxhGey__lw_AhiNmL0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16472687</pqid></control><display><type>article</type><title>The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Staunton, Michael ; Dulitz, Michael G ; Fang, Celia ; Schmeling, William T ; Kampine, John P ; Farber, Neil E</creator><creatorcontrib>Staunton, Michael ; Dulitz, Michael G ; Fang, Celia ; Schmeling, William T ; Kampine, John P ; Farber, Neil E</creatorcontrib><description>HYPOXIA-INDUCED changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was maintained at 500 mmHg. In groups 2 and 3, PO2 was gradually reduced to anoxia (95% N2/5% CO2). In group 3, prostaglandin F2aα was given to approximate physiological myogenic tone. PCO2 and pH were controlled. Graded hypoxia progressively dilated vessels (PO2 300 mmHg = 2.4±1.2%, 4.2 ± 1.6%; PO2 90 mHg= 15.4 ± 3.0%, 14.5 ± 1.8%; groups 2 and 3, respectively). The presence of preconstriction did not influence the extent of hypoxia-induced dilation. This vasorelaxation may be important in maintaining cerebral oxygen delivery during microvascular hypoxia.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199805110-00031</identifier><identifier>PMID: 9631440</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Arterioles - drug effects ; Arterioles - physiology ; Biological and medical sciences ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebrovascular Circulation - physiology ; Dinoprost - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hippocampus - blood supply ; Hypoxia, Brain ; In Vitro Techniques ; Male ; Microscopy, Video - methods ; Oxygen - pharmacology ; Partial Pressure ; Rats ; Rats, Sprague-Dawley ; Vasodilation - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1998-05, Vol.9 (7), p.1419-1423</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4151-20b8f3e5ef30044c941a73da01bbc90bb81416d49f694e941fed2f009f7439873</citedby><cites>FETCH-LOGICAL-c4151-20b8f3e5ef30044c941a73da01bbc90bb81416d49f694e941fed2f009f7439873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2249919$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9631440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staunton, Michael</creatorcontrib><creatorcontrib>Dulitz, Michael G</creatorcontrib><creatorcontrib>Fang, Celia</creatorcontrib><creatorcontrib>Schmeling, William T</creatorcontrib><creatorcontrib>Kampine, John P</creatorcontrib><creatorcontrib>Farber, Neil E</creatorcontrib><title>The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>HYPOXIA-INDUCED changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was maintained at 500 mmHg. In groups 2 and 3, PO2 was gradually reduced to anoxia (95% N2/5% CO2). In group 3, prostaglandin F2aα was given to approximate physiological myogenic tone. PCO2 and pH were controlled. Graded hypoxia progressively dilated vessels (PO2 300 mmHg = 2.4±1.2%, 4.2 ± 1.6%; PO2 90 mHg= 15.4 ± 3.0%, 14.5 ± 1.8%; groups 2 and 3, respectively). The presence of preconstriction did not influence the extent of hypoxia-induced dilation. This vasorelaxation may be important in maintaining cerebral oxygen delivery during microvascular hypoxia.</description><subject>Animals</subject><subject>Arterioles - drug effects</subject><subject>Arterioles - physiology</subject><subject>Biological and medical sciences</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Dinoprost - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - blood supply</subject><subject>Hypoxia, Brain</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Microscopy, Video - methods</subject><subject>Oxygen - pharmacology</subject><subject>Partial Pressure</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vasodilation - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1U1G5bfgKSD6i3gCd2PuaIKgpIleBQJG7WxBmTgDfZ2lmV_fd1u9u9IXyx5feZGeuxEBLUe1DYfFB5QVPVBSC2qgJQRb7R8EqswDS6qKr254lYKaywMFhXZ-I8pd8ZQQXtqTjFWoMxaiW-3w0s2Xt2S5Kzl78i9dzLYbeZ_44k50mO0xJpQ5EnN-zWFCTFheM4B045k5EW2UXKpxRGx-lSvPYUEr857Bfix82nu-svxe23z1-vP94WzkAFRam61muu2GuljHFogBrdk4Kuc6i6rgUDdW_Q12g4p5770uf3-8ZobBt9Ia72fTdxvt9yWux6TI5DoInnbbINotFZw39BqE1T1s8d2z3o4pxSZG83cVxT3FlQ9sm6fbFuj9bts_Vc-vYwY9utuT8WHjTn_N0hp-Qo-EiTG9MRK0uDCJgxs8ce5pAdpz9h-8DRDkxhGey__lw_AhiNmL0</recordid><startdate>19980511</startdate><enddate>19980511</enddate><creator>Staunton, Michael</creator><creator>Dulitz, Michael G</creator><creator>Fang, Celia</creator><creator>Schmeling, William T</creator><creator>Kampine, John P</creator><creator>Farber, Neil E</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980511</creationdate><title>The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices</title><author>Staunton, Michael ; Dulitz, Michael G ; Fang, Celia ; Schmeling, William T ; Kampine, John P ; Farber, Neil E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4151-20b8f3e5ef30044c941a73da01bbc90bb81416d49f694e941fed2f009f7439873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Arterioles - drug effects</topic><topic>Arterioles - physiology</topic><topic>Biological and medical sciences</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Dinoprost - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - blood supply</topic><topic>Hypoxia, Brain</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Microscopy, Video - methods</topic><topic>Oxygen - pharmacology</topic><topic>Partial Pressure</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vasodilation - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Staunton, Michael</creatorcontrib><creatorcontrib>Dulitz, Michael G</creatorcontrib><creatorcontrib>Fang, Celia</creatorcontrib><creatorcontrib>Schmeling, William T</creatorcontrib><creatorcontrib>Kampine, John P</creatorcontrib><creatorcontrib>Farber, Neil E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staunton, Michael</au><au>Dulitz, Michael G</au><au>Fang, Celia</au><au>Schmeling, William T</au><au>Kampine, John P</au><au>Farber, Neil E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1998-05-11</date><risdate>1998</risdate><volume>9</volume><issue>7</issue><spage>1419</spage><epage>1423</epage><pages>1419-1423</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>HYPOXIA-INDUCED changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was maintained at 500 mmHg. In groups 2 and 3, PO2 was gradually reduced to anoxia (95% N2/5% CO2). In group 3, prostaglandin F2aα was given to approximate physiological myogenic tone. PCO2 and pH were controlled. Graded hypoxia progressively dilated vessels (PO2 300 mmHg = 2.4±1.2%, 4.2 ± 1.6%; PO2 90 mHg= 15.4 ± 3.0%, 14.5 ± 1.8%; groups 2 and 3, respectively). The presence of preconstriction did not influence the extent of hypoxia-induced dilation. This vasorelaxation may be important in maintaining cerebral oxygen delivery during microvascular hypoxia.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9631440</pmid><doi>10.1097/00001756-199805110-00031</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1998-05, Vol.9 (7), p.1419-1423 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79943558 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Arterioles - drug effects Arterioles - physiology Biological and medical sciences Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - physiology Dinoprost - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus - blood supply Hypoxia, Brain In Vitro Techniques Male Microscopy, Video - methods Oxygen - pharmacology Partial Pressure Rats Rats, Sprague-Dawley Vasodilation - physiology Vertebrates: nervous system and sense organs |
| title | The effects of graded hypoxia on intraparenchymal arterioles in rat brain slices |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T20%3A27%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20graded%20hypoxia%20on%20intraparenchymal%20arterioles%20in%20rat%20brain%20slices&rft.jtitle=Neuroreport&rft.au=Staunton,%20Michael&rft.date=1998-05-11&rft.volume=9&rft.issue=7&rft.spage=1419&rft.epage=1423&rft.pages=1419-1423&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/00001756-199805110-00031&rft_dat=%3Cproquest_cross%3E79943558%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16472687&rft_id=info:pmid/9631440&rfr_iscdi=true |