Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia
Background: Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a distinctive palisading granuloma of the skin. Extracutaneous lesions are rarely present. Objective: The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclu...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1998-06, Vol.38 (6), p.967-970 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Winkelmann, R.K. Dahl, Patrick M. Perniciaro, Charles |
| description | Background: Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a distinctive palisading granuloma of the skin. Extracutaneous lesions are rarely present.
Objective: The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclusions in NXG with paraproteinemia.
Methods: Skin biopsy specimens from 24 patients with NXG with paraproteinemia were reviewed; autopsy and lung biopsy specimens from two patients were stained for iron, calcium, and polysaccharide.
Results: Giant cell asteroid bodies were observed in skin biopsy specimens of 8 (33%) of the 24 patients. In addition, large acidophilic polygonal cytoplasmic inclusions were observed in myocardial tissue of one of the autopsy cases. Iron and calcium were not found.
Conclusion: Asteroid bodies and other inclusions can be present in the giant cells of NXG with paraproteinemia. They are as frequent as, or more frequent than, in other granulomatous diseases and should be considered in the diagnosis of NXG with paraproteinemia.(J Am Acad Dermatol 1998;38:967-70.) |
| doi_str_mv | 10.1016/S0190-9622(98)70161-6 |
| format | Article |
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Objective: The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclusions in NXG with paraproteinemia.
Methods: Skin biopsy specimens from 24 patients with NXG with paraproteinemia were reviewed; autopsy and lung biopsy specimens from two patients were stained for iron, calcium, and polysaccharide.
Results: Giant cell asteroid bodies were observed in skin biopsy specimens of 8 (33%) of the 24 patients. In addition, large acidophilic polygonal cytoplasmic inclusions were observed in myocardial tissue of one of the autopsy cases. Iron and calcium were not found.
Conclusion: Asteroid bodies and other inclusions can be present in the giant cells of NXG with paraproteinemia. They are as frequent as, or more frequent than, in other granulomatous diseases and should be considered in the diagnosis of NXG with paraproteinemia.(J Am Acad Dermatol 1998;38:967-70.)</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(98)70161-6</identifier><identifier>PMID: 9632006</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Dermatology ; Giant Cells - pathology ; Granuloma - complications ; Granuloma - pathology ; Humans ; Inclusion Bodies - pathology ; Medical sciences ; Myocardium - pathology ; Paraproteinemias - complications ; Skin - pathology ; Tumors of the skin and soft tissue. Premalignant lesions ; Xanthomatosis - complications ; Xanthomatosis - pathology</subject><ispartof>Journal of the American Academy of Dermatology, 1998-06, Vol.38 (6), p.967-970</ispartof><rights>1998 American Academy of Dermatology, Inc</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-745fbde0f18567e8980d894eb683259ae4a2459e934a19ad0d6bc4998cd013b3</citedby><cites>FETCH-LOGICAL-c441t-745fbde0f18567e8980d894eb683259ae4a2459e934a19ad0d6bc4998cd013b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0190-9622(98)70161-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2268208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9632006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winkelmann, R.K.</creatorcontrib><creatorcontrib>Dahl, Patrick M.</creatorcontrib><creatorcontrib>Perniciaro, Charles</creatorcontrib><title>Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background: Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a distinctive palisading granuloma of the skin. Extracutaneous lesions are rarely present.
Objective: The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclusions in NXG with paraproteinemia.
Methods: Skin biopsy specimens from 24 patients with NXG with paraproteinemia were reviewed; autopsy and lung biopsy specimens from two patients were stained for iron, calcium, and polysaccharide.
Results: Giant cell asteroid bodies were observed in skin biopsy specimens of 8 (33%) of the 24 patients. In addition, large acidophilic polygonal cytoplasmic inclusions were observed in myocardial tissue of one of the autopsy cases. Iron and calcium were not found.
Conclusion: Asteroid bodies and other inclusions can be present in the giant cells of NXG with paraproteinemia. They are as frequent as, or more frequent than, in other granulomatous diseases and should be considered in the diagnosis of NXG with paraproteinemia.(J Am Acad Dermatol 1998;38:967-70.)</description><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Giant Cells - pathology</subject><subject>Granuloma - complications</subject><subject>Granuloma - pathology</subject><subject>Humans</subject><subject>Inclusion Bodies - pathology</subject><subject>Medical sciences</subject><subject>Myocardium - pathology</subject><subject>Paraproteinemias - complications</subject><subject>Skin - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Xanthomatosis - complications</subject><subject>Xanthomatosis - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qFWyhPwEpB1TBIWAnjmOfEEL9QELiAHdrYk-6rhJ7sR0-_n0Nu9prT7b8PuOZeQg5YfSCUSYuHyhTtFaiac6UPO_LE6vFJ7JiVPW16GX_maz2yCH5mtJfSqnibX9ADpRoG0rFitjrlDEGZ6shWIepAm-rkNcYK_OWw2aCNDtTOW-mJbngU7lWHk0Mgwu5JK_g8zr8ieCXKcxQvbi8rjYQYRNDRudxdnBMvowwJfy2O4_I488fjze_67v7X7c313e14ZzluufdOFikI5Od6FEqSa1UHAch26ZTgBwa3ilULQemwFIrBsOVksZS1g7tEfm-_ba0flowZT27ZHCawGNYku5V2Z4LXsBuC5Y1Uoo46k10M8Q3zah-l6s_5Op3c1pJ_SFXi1J3smuwDDPafdXOZslPdzkkA9NYpBiX9ljTCNlQWbCrLYbFxbPDqJNx6A1aF9FkbYP7zyD_ACF4mDc</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Winkelmann, R.K.</creator><creator>Dahl, Patrick M.</creator><creator>Perniciaro, Charles</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia</title><author>Winkelmann, R.K. ; Dahl, Patrick M. ; Perniciaro, Charles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-745fbde0f18567e8980d894eb683259ae4a2459e934a19ad0d6bc4998cd013b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Giant Cells - pathology</topic><topic>Granuloma - complications</topic><topic>Granuloma - pathology</topic><topic>Humans</topic><topic>Inclusion Bodies - pathology</topic><topic>Medical sciences</topic><topic>Myocardium - pathology</topic><topic>Paraproteinemias - complications</topic><topic>Skin - pathology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Xanthomatosis - complications</topic><topic>Xanthomatosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winkelmann, R.K.</creatorcontrib><creatorcontrib>Dahl, Patrick M.</creatorcontrib><creatorcontrib>Perniciaro, Charles</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winkelmann, R.K.</au><au>Dahl, Patrick M.</au><au>Perniciaro, Charles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>38</volume><issue>6</issue><spage>967</spage><epage>970</epage><pages>967-970</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Background: Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a distinctive palisading granuloma of the skin. Extracutaneous lesions are rarely present.
Objective: The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclusions in NXG with paraproteinemia.
Methods: Skin biopsy specimens from 24 patients with NXG with paraproteinemia were reviewed; autopsy and lung biopsy specimens from two patients were stained for iron, calcium, and polysaccharide.
Results: Giant cell asteroid bodies were observed in skin biopsy specimens of 8 (33%) of the 24 patients. In addition, large acidophilic polygonal cytoplasmic inclusions were observed in myocardial tissue of one of the autopsy cases. Iron and calcium were not found.
Conclusion: Asteroid bodies and other inclusions can be present in the giant cells of NXG with paraproteinemia. They are as frequent as, or more frequent than, in other granulomatous diseases and should be considered in the diagnosis of NXG with paraproteinemia.(J Am Acad Dermatol 1998;38:967-70.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9632006</pmid><doi>10.1016/S0190-9622(98)70161-6</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Dermatology, 1998-06, Vol.38 (6), p.967-970 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Dermatology Giant Cells - pathology Granuloma - complications Granuloma - pathology Humans Inclusion Bodies - pathology Medical sciences Myocardium - pathology Paraproteinemias - complications Skin - pathology Tumors of the skin and soft tissue. Premalignant lesions Xanthomatosis - complications Xanthomatosis - pathology |
| title | Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia |
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