Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade

Src transformation of NIH3T3 mouse fibroblasts has been shown to be dependent on Ras function. Since we recently showed that the signaling pathways that mediate Ras transformation of RIE-1 rat intestinal epithelial cells are distinct from those that cause Ras transformation of fibroblasts, we utiliz...

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Veröffentlicht in:	Oncogene 1998-05, Vol.16 (20), p.2565-2573
Hauptverfasser:	OLDHAM, S. M, COX, A. D, REYNOLDS, E. R, SIZEMORE, N. S, COFFEY, R. J, DER, C. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - antagonists & inhibitors Animals Autocrine signalling Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell activation Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cells, Cultured Enzyme Inhibitors - pharmacology Epidermal growth factor Epithelial cells Epithelial Cells - pathology Farnesyltransferase Farnesyltranstransferase Fibroblasts Fundamental and applied biological sciences. Psychology Genes, ras Genes, src Kinases MAP kinase MEK inhibitors Methionine - analogs & derivatives Methionine - pharmacology Molecular and cellular biology Mutation Protein kinase Protein kinase C Proto-Oncogene Proteins c-raf - metabolism Raf protein Ras protein Rats Receptor, Epidermal Growth Factor - metabolism Src protein Up-Regulation
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