CMV-viraemia during allogenic bone marrow transplantation in paediatric patients: association with survival and graft-versus-host disease
Sixty-one consecutive paediatric patients undergoing allogenic bone marrow transplantation (BMT) were screened prospectively for cytomegalovirus (CMV)-viraemia by PCR. Sixteen patients (26%) presented with single or recurrent CMV-viraemia between day -7 and + 100. Although only four of them had evid...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 1998-04, Vol.21 Suppl 2, p.S53-S56 |
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| container_title | Bone marrow transplantation (Basingstoke) |
| container_volume | 21 Suppl 2 |
| creator | Matthes-Martin, S Aberle, S W Peters, C Holter, W Popow-Kraupp, T Pötschger, U Fritsch, G Ladenstein, R Rosenmayer, A Dieckmann, K Gadner, H |
| description | Sixty-one consecutive paediatric patients undergoing allogenic bone marrow transplantation (BMT) were screened prospectively for cytomegalovirus (CMV)-viraemia by PCR. Sixteen patients (26%) presented with single or recurrent CMV-viraemia between day -7 and + 100. Although only four of them had evidence of CMV-disease, there was a significant difference in the incidence of acute Graft versus Host Disease (GVHD) grade III-IV (75% vs 15.5%), liver-involvement (68% vs 13%) and the incidence of chronic GVHD (83% vs 13.8%) between CMV-PCR-positive and CMV-PCR-negative patients. Transplant-related mortality (TRM) was 43.7% in the CMV-PCR-positive group versus 13% in patients which had no evidence for CMV-viraemia. In all but one cases mortality in CMV-PCR positive patients was GVHD-associated. Pre-emptive therapy with gancyclovir in case of CMV-viraemia seemed to have no impact on incidence and severity of GVHD. |
| format | Article |
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Sixteen patients (26%) presented with single or recurrent CMV-viraemia between day -7 and + 100. Although only four of them had evidence of CMV-disease, there was a significant difference in the incidence of acute Graft versus Host Disease (GVHD) grade III-IV (75% vs 15.5%), liver-involvement (68% vs 13%) and the incidence of chronic GVHD (83% vs 13.8%) between CMV-PCR-positive and CMV-PCR-negative patients. Transplant-related mortality (TRM) was 43.7% in the CMV-PCR-positive group versus 13% in patients which had no evidence for CMV-viraemia. In all but one cases mortality in CMV-PCR positive patients was GVHD-associated. Pre-emptive therapy with gancyclovir in case of CMV-viraemia seemed to have no impact on incidence and severity of GVHD.</description><identifier>ISSN: 0268-3369</identifier><identifier>PMID: 9630327</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Bone Marrow Transplantation - adverse effects ; Child ; Child, Preschool ; Cytomegalovirus Infections - etiology ; Female ; Graft vs Host Disease - etiology ; Humans ; Infant ; Leukemia - mortality ; Leukemia - therapy ; Male ; Prospective Studies ; Transplantation, Homologous ; Viremia - etiology</subject><ispartof>Bone marrow transplantation (Basingstoke), 1998-04, Vol.21 Suppl 2, p.S53-S56</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9630327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matthes-Martin, S</creatorcontrib><creatorcontrib>Aberle, S W</creatorcontrib><creatorcontrib>Peters, C</creatorcontrib><creatorcontrib>Holter, W</creatorcontrib><creatorcontrib>Popow-Kraupp, T</creatorcontrib><creatorcontrib>Pötschger, U</creatorcontrib><creatorcontrib>Fritsch, G</creatorcontrib><creatorcontrib>Ladenstein, R</creatorcontrib><creatorcontrib>Rosenmayer, A</creatorcontrib><creatorcontrib>Dieckmann, K</creatorcontrib><creatorcontrib>Gadner, H</creatorcontrib><title>CMV-viraemia during allogenic bone marrow transplantation in paediatric patients: association with survival and graft-versus-host disease</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>Sixty-one consecutive paediatric patients undergoing allogenic bone marrow transplantation (BMT) were screened prospectively for cytomegalovirus (CMV)-viraemia by PCR. Sixteen patients (26%) presented with single or recurrent CMV-viraemia between day -7 and + 100. Although only four of them had evidence of CMV-disease, there was a significant difference in the incidence of acute Graft versus Host Disease (GVHD) grade III-IV (75% vs 15.5%), liver-involvement (68% vs 13%) and the incidence of chronic GVHD (83% vs 13.8%) between CMV-PCR-positive and CMV-PCR-negative patients. Transplant-related mortality (TRM) was 43.7% in the CMV-PCR-positive group versus 13% in patients which had no evidence for CMV-viraemia. In all but one cases mortality in CMV-PCR positive patients was GVHD-associated. Pre-emptive therapy with gancyclovir in case of CMV-viraemia seemed to have no impact on incidence and severity of GVHD.</description><subject>Adolescent</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytomegalovirus Infections - etiology</subject><subject>Female</subject><subject>Graft vs Host Disease - etiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemia - mortality</subject><subject>Leukemia - therapy</subject><subject>Male</subject><subject>Prospective Studies</subject><subject>Transplantation, Homologous</subject><subject>Viremia - etiology</subject><issn>0268-3369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAQwPEelHVd_QhCTt4CadLHxpssvmDFi3otk0d3I21SM2kXP4Lf2sLu3dPA8GNg_mfZkvFqTYWo5EV2ifjFWF4UrFxkC1kJJni9zH43r590chFs74CYMTq_I9B1YWe900QFb0kPMYYDSRE8Dh34BMkFT5wnA1jjIMVZDvPS-oR3BBCDdkdzcGlPcIyTm6Aj4A3ZRWgTnWzEEek-YCLGoQW0V9l5Cx3a69NcZR-PD--bZ7p9e3rZ3G_pwIVM1DLNTSnaimnZ5lrk5brMtVS1qkCLqjUaNAPGVSEN0yWoFowtC6Z0Xiquc7HKbo93hxi-R4up6R1q282P2TBiU0tZsGIO9B_Mq4LzWq5neHOCo-qtaYbo5mQ_zSmy-AMN_Hwk</recordid><startdate>199804</startdate><enddate>199804</enddate><creator>Matthes-Martin, S</creator><creator>Aberle, S W</creator><creator>Peters, C</creator><creator>Holter, W</creator><creator>Popow-Kraupp, T</creator><creator>Pötschger, U</creator><creator>Fritsch, G</creator><creator>Ladenstein, R</creator><creator>Rosenmayer, A</creator><creator>Dieckmann, K</creator><creator>Gadner, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199804</creationdate><title>CMV-viraemia during allogenic bone marrow transplantation in paediatric patients: association with survival and graft-versus-host disease</title><author>Matthes-Martin, S ; Aberle, S W ; Peters, C ; Holter, W ; Popow-Kraupp, T ; Pötschger, U ; Fritsch, G ; Ladenstein, R ; Rosenmayer, A ; Dieckmann, K ; Gadner, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-e0c2d53f60c9f1c315851c9b7b6ac36fdcac0a02b49d0c5abfade540bc15b2c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytomegalovirus Infections - etiology</topic><topic>Female</topic><topic>Graft vs Host Disease - etiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemia - mortality</topic><topic>Leukemia - therapy</topic><topic>Male</topic><topic>Prospective Studies</topic><topic>Transplantation, Homologous</topic><topic>Viremia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matthes-Martin, S</creatorcontrib><creatorcontrib>Aberle, S W</creatorcontrib><creatorcontrib>Peters, C</creatorcontrib><creatorcontrib>Holter, W</creatorcontrib><creatorcontrib>Popow-Kraupp, T</creatorcontrib><creatorcontrib>Pötschger, U</creatorcontrib><creatorcontrib>Fritsch, G</creatorcontrib><creatorcontrib>Ladenstein, R</creatorcontrib><creatorcontrib>Rosenmayer, A</creatorcontrib><creatorcontrib>Dieckmann, K</creatorcontrib><creatorcontrib>Gadner, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matthes-Martin, S</au><au>Aberle, S W</au><au>Peters, C</au><au>Holter, W</au><au>Popow-Kraupp, T</au><au>Pötschger, U</au><au>Fritsch, G</au><au>Ladenstein, R</au><au>Rosenmayer, A</au><au>Dieckmann, K</au><au>Gadner, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CMV-viraemia during allogenic bone marrow transplantation in paediatric patients: association with survival and graft-versus-host disease</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><addtitle>Bone Marrow Transplant</addtitle><date>1998-04</date><risdate>1998</risdate><volume>21 Suppl 2</volume><spage>S53</spage><epage>S56</epage><pages>S53-S56</pages><issn>0268-3369</issn><abstract>Sixty-one consecutive paediatric patients undergoing allogenic bone marrow transplantation (BMT) were screened prospectively for cytomegalovirus (CMV)-viraemia by PCR. Sixteen patients (26%) presented with single or recurrent CMV-viraemia between day -7 and + 100. Although only four of them had evidence of CMV-disease, there was a significant difference in the incidence of acute Graft versus Host Disease (GVHD) grade III-IV (75% vs 15.5%), liver-involvement (68% vs 13%) and the incidence of chronic GVHD (83% vs 13.8%) between CMV-PCR-positive and CMV-PCR-negative patients. Transplant-related mortality (TRM) was 43.7% in the CMV-PCR-positive group versus 13% in patients which had no evidence for CMV-viraemia. In all but one cases mortality in CMV-PCR positive patients was GVHD-associated. Pre-emptive therapy with gancyclovir in case of CMV-viraemia seemed to have no impact on incidence and severity of GVHD.</abstract><cop>England</cop><pmid>9630327</pmid></addata></record> |
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| ispartof | Bone marrow transplantation (Basingstoke), 1998-04, Vol.21 Suppl 2, p.S53-S56 |
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| source | MEDLINE; SpringerLink Journals; Nature; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Bone Marrow Transplantation - adverse effects Child Child, Preschool Cytomegalovirus Infections - etiology Female Graft vs Host Disease - etiology Humans Infant Leukemia - mortality Leukemia - therapy Male Prospective Studies Transplantation, Homologous Viremia - etiology |
| title | CMV-viraemia during allogenic bone marrow transplantation in paediatric patients: association with survival and graft-versus-host disease |
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