Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder
NERVE growth factor (NGF) is a mediator of hyperalgesia and has been previously associated with sensory and reflex changes after inflammation of the urinary bladder. A sensitive assay was developed to examine neurotrophin gene expression after bladder inflammation by turpentine, which causes a short...
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| Veröffentlicht in: | Neuroreport 1998-05, Vol.9 (7), p.1455-1458 |
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| creator | Oddiah, Daniela Anand, Praveen McMahon, Stephen B Rattray, Marcus |
| description | NERVE growth factor (NGF) is a mediator of hyperalgesia and has been previously associated with sensory and reflex changes after inflammation of the urinary bladder. A sensitive assay was developed to examine neurotrophin gene expression after bladder inflammation by turpentine, which causes a short-lived inflammatory response. Two hours, but not 6 or after induction of inflammation, there were significant increases in levels of NGF, brain-derived neurotrophic factor and neurotrophin-3 mRNAs. NGF immunoreactivity was elevated with a similar time course to its mRNA. Our results suggest that during bladder inflammation, endogenous NGF is rapidly up-regulated and released to mediating sensory and reflex changes. Brain-derived neurotrophic factor and neurotrophin-3 may also have a role in the inflammatory response. |
| doi_str_mv | 10.1097/00001756-199805110-00038 |
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A sensitive assay was developed to examine neurotrophin gene expression after bladder inflammation by turpentine, which causes a short-lived inflammatory response. Two hours, but not 6 or after induction of inflammation, there were significant increases in levels of NGF, brain-derived neurotrophic factor and neurotrophin-3 mRNAs. NGF immunoreactivity was elevated with a similar time course to its mRNA. Our results suggest that during bladder inflammation, endogenous NGF is rapidly up-regulated and released to mediating sensory and reflex changes. 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A sensitive assay was developed to examine neurotrophin gene expression after bladder inflammation by turpentine, which causes a short-lived inflammatory response. Two hours, but not 6 or after induction of inflammation, there were significant increases in levels of NGF, brain-derived neurotrophic factor and neurotrophin-3 mRNAs. NGF immunoreactivity was elevated with a similar time course to its mRNA. Our results suggest that during bladder inflammation, endogenous NGF is rapidly up-regulated and released to mediating sensory and reflex changes. Brain-derived neurotrophic factor and neurotrophin-3 may also have a role in the inflammatory response.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain-Derived Neurotrophic Factor - biosynthesis</subject><subject>DNA Primers</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Situ Hybridization</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - metabolism</subject><subject>Nerve Growth Factors - biosynthesis</subject><subject>Neurotrophin 3</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Transcription, Genetic</subject><subject>Turpentine</subject><subject>Urinary Bladder - metabolism</subject><subject>Urinary Bladder - physiopathology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEQgIMoWh8_QchBPLma2SSbzEXwVRWkgih4C9lsFlfTbk1axH9vtLU3MQQyZL6ZMF8IocCOgaE6YXmBklUBiJpJAFbkG67XyACE4oWU-nmdDBhKLARWcotsp_SaEWSgN8kmVhyEUANy-mCnXUO7iYveJk_7lo6uh0f0_HI0pHbS0NFjwen4YXSWMpR3G-zYN7QOtml83CUbrQ3J7y3PHfI0vHq8uCnu7q9vL87uCic06EJoV4HTpeOi1shK5KpV0jIQqKzWHGWexnHVqNrnsOKszKHzeTYNCmq-Qw4Xfaexf5_7NDPjLjkfgp34fp6MQhSMA_8XhEqokiFkUC9AF_uUom_NNHZjGz8NMPPt2Pw6NivH5sdxLt1fvjGvs4tV4VJqzh8s8zY5G9poJ65LK6wspUb8xsQC--jDzMf0FuYfPpoXb8Psxfz1w_wLQMiN4w</recordid><startdate>19980511</startdate><enddate>19980511</enddate><creator>Oddiah, Daniela</creator><creator>Anand, Praveen</creator><creator>McMahon, Stephen B</creator><creator>Rattray, Marcus</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980511</creationdate><title>Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder</title><author>Oddiah, Daniela ; Anand, Praveen ; McMahon, Stephen B ; Rattray, Marcus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4818-48c61c82c34b8902937f75a01497a88395017c37d7be5016302d7bce9808171b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain-Derived Neurotrophic Factor - biosynthesis</topic><topic>DNA Primers</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Situ Hybridization</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - metabolism</topic><topic>Nerve Growth Factors - biosynthesis</topic><topic>Neurotrophin 3</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Transcription, Genetic</topic><topic>Turpentine</topic><topic>Urinary Bladder - metabolism</topic><topic>Urinary Bladder - physiopathology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oddiah, Daniela</creatorcontrib><creatorcontrib>Anand, Praveen</creatorcontrib><creatorcontrib>McMahon, Stephen B</creatorcontrib><creatorcontrib>Rattray, Marcus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oddiah, Daniela</au><au>Anand, Praveen</au><au>McMahon, Stephen B</au><au>Rattray, Marcus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1998-05-11</date><risdate>1998</risdate><volume>9</volume><issue>7</issue><spage>1455</spage><epage>1458</epage><pages>1455-1458</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>NERVE growth factor (NGF) is a mediator of hyperalgesia and has been previously associated with sensory and reflex changes after inflammation of the urinary bladder. A sensitive assay was developed to examine neurotrophin gene expression after bladder inflammation by turpentine, which causes a short-lived inflammatory response. Two hours, but not 6 or after induction of inflammation, there were significant increases in levels of NGF, brain-derived neurotrophic factor and neurotrophin-3 mRNAs. NGF immunoreactivity was elevated with a similar time course to its mRNA. Our results suggest that during bladder inflammation, endogenous NGF is rapidly up-regulated and released to mediating sensory and reflex changes. Brain-derived neurotrophic factor and neurotrophin-3 may also have a role in the inflammatory response.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9631447</pmid><doi>10.1097/00001756-199805110-00038</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroreport, 1998-05, Vol.9 (7), p.1455-1458 |
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| subjects | Animals Biological and medical sciences Brain-Derived Neurotrophic Factor - biosynthesis DNA Primers Female Fundamental and applied biological sciences. Psychology In Situ Hybridization Inflammation - chemically induced Inflammation - metabolism Nerve Growth Factors - biosynthesis Neurotrophin 3 Rats Rats, Wistar RNA, Messenger - biosynthesis Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Transcription, Genetic Turpentine Urinary Bladder - metabolism Urinary Bladder - physiopathology Vertebrates: nervous system and sense organs |
| title | Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder |
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