Sustained hypoxia-ischemia results in reactive nitrogen and oxygen species production and injury in the premature fetal rabbit brain

Free radical-mediated injury is implicated in hypoxic-ischemic encephalopathy observed in neonates. We investigated in utero free radical production and injury following hypoxia-ischemia to premature fetal brain utilizing a rabbit model of acute placental insufficiency. Pregnant rabbits at 29 days g...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 1998-06, Vol.57 (6), p.544-553
Hauptverfasser:	SIDHARTHA TAN, FEN ZHOU, NIELSEN, V. G, ZIWEI WANG, GLADSON, C. L, PARKS, D. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antioxidants (Nutrients) Antioxidants - pharmacology Ascorbic Acid - pharmacology Biological and medical sciences Brain Brain - cytology Brain - embryology Brain - metabolism Brain Ischemia - metabolism Cell Death - drug effects Cell Survival - drug effects Chromans - pharmacology Female Free Radicals - metabolism Hypoxia, Brain - metabolism Ischemia Lipid peroxidation Medical sciences Neurology Nitrogen - metabolism Nitrogen oxides Oxidative Stress - drug effects Oxidative Stress - physiology Pregnancy Pregnant women Rabbits Reactive Oxygen Species - metabolism Uterus - blood supply Vascular diseases and vascular malformations of the nervous system
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