Phage T4 DNA [N 6 -Adenine] Methyltransferase: Kinetic Studies Using Oligonucleotides Containing Native or Modified Recognition Sites

The DNA-[N6-adenine] methyltransferase of T4 phage (T4 Dam MTase) catalyzes methyl group transfer from S-adenosyl-L-methionine (AdoMet) to the N6-position of adenine in the palindromic sequence, GATC. We have investigated the effect of eliminating different structural components of the recognition s...

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Veröffentlicht in:	Biological Chemistry 1998-04, Vol.379 (4-5), p.481-488
Hauptverfasser:	Zinoviev, Victor V., Evdokimov, Alexei A., Gorbunov, Yuri A., Malygin, Ernst G., Kossykh, Valeri G., Hattman, Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage T4 - enzymology Binding Sites DNA Methylation Kinetics Nucleic Acid Heteroduplexes - metabolism Oligodeoxyribonucleotides - metabolism Site-Specific DNA-Methyltransferase (Adenine-Specific) - metabolism Substrate Specificity Temperature Viral Proteins
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