Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

The spatial relation between mitochondria and endoplasmic reticulum (ER) in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins. Numerous close contacts were observed between these organelles, and mitoch...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-06, Vol.280 (5370), p.1763-1765
Hauptverfasser:	RIZZUTO, R, PINTON, P, CARRINGTON, W, FAY, F. S, FOGARTY, K. E, LIFSHITZ, L. M, TUFT, R. A, POZZAN, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Aequorin - metabolism Biological and medical sciences Calcium Calcium (Chemical element) Calcium - metabolism Calcium Channels - metabolism Cell Compartmentation Cell structures and functions Cells Cytosol - metabolism Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins HeLa Cells Histamine - pharmacology Humans Inositol 1,4,5-Trisphosphate - metabolism Intracellular Membranes - metabolism Ion Channel Gating Luminescent Proteins - metabolism Mitochondria Mitochondria - metabolism Mitochondria - ultrastructure Mitochondria and cell respiration Molecular and cellular biology Networks Physiological aspects Proteins Recombinant Fusion Proteins - metabolism Signal Transduction Transfection
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