Structure and function relationships of the respiratory muscles
Potential relationships between the structure of the diaphragm and external intercostals and several indices of respiratory muscle function, lung function and nutrition in 27 patients (61+/-10 yrs of age) subjected to thoracotomy as a result of a lung neoplasm have been investigated. Prior to surger...
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| Veröffentlicht in: | The European respiratory journal 1998-04, Vol.11 (4), p.906-911 |
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| creator | Sauleda, J Gea, J Orozco-Levi, M Corominas, J Minguella, J Aguar, C Broquetas, J Agusti, AG |
| description | Potential relationships between the structure of the diaphragm and external intercostals and several indices of respiratory muscle function, lung function and nutrition in 27 patients (61+/-10 yrs of age) subjected to thoracotomy as a result of a lung neoplasm have been investigated. Prior to surgery the nutritional status of the patients was assessed and lung function (spirometry, lung volumes, transfer factor of the lungs for carbon monoxide, arterial blood gases) and respiratory muscle function (maximal inspiratory pressure (MIP) and diaphragmatic function were measured). Biopsies of the diaphragm (and external intercostals) were obtained during surgery. On average, patients showed mild airflow limitation (forced expiratory volume in one second (FEV1), 70+/-14% of predicted value, FEV1/forced vital capacity (FVC), 70+/-9%) with some air trapping (residual volume (RV), 139+/-50% pred) and normal gas exchange (arterial oxygen tension (Pa,O2), 11.3+/-1.33 kPa (85+/-10 mmHg)) and arterial carbon dioxide tension (Pa,CO2) 5.4+/-0.5 kPa (40.6+/-4 mmHg). MIP was 77+/-25% pred; maximal transdiaphragmatic pressure was 90+/-27 cmH2O. Most morphometric measurements of the diaphragm and external intercostals were within the range of values reported previously in other skeletal muscles. The size of the fibres of these two respiratory muscles was positively related (p |
| doi_str_mv | 10.1183/09031936.98.11040906 |
| format | Article |
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Prior to surgery the nutritional status of the patients was assessed and lung function (spirometry, lung volumes, transfer factor of the lungs for carbon monoxide, arterial blood gases) and respiratory muscle function (maximal inspiratory pressure (MIP) and diaphragmatic function were measured). Biopsies of the diaphragm (and external intercostals) were obtained during surgery. On average, patients showed mild airflow limitation (forced expiratory volume in one second (FEV1), 70+/-14% of predicted value, FEV1/forced vital capacity (FVC), 70+/-9%) with some air trapping (residual volume (RV), 139+/-50% pred) and normal gas exchange (arterial oxygen tension (Pa,O2), 11.3+/-1.33 kPa (85+/-10 mmHg)) and arterial carbon dioxide tension (Pa,CO2) 5.4+/-0.5 kPa (40.6+/-4 mmHg). MIP was 77+/-25% pred; maximal transdiaphragmatic pressure was 90+/-27 cmH2O. Most morphometric measurements of the diaphragm and external intercostals were within the range of values reported previously in other skeletal muscles. The size of the fibres of these two respiratory muscles was positively related (p<0.05) to MIP (% pred). There were no significant relationships between the structure of both muscles and nutritional status or any index of lung function. In conclusion, in the population studied, the fibre size of the diaphragm and external intercostals appears to relate to their ability to generate force.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.98.11040906</identifier><identifier>PMID: 9623696</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Biological and medical sciences ; Diaphragm - physiology ; Humans ; Intercostal Muscles - physiology ; Investigative techniques of respiratory function ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Muscle Fibers, Skeletal - cytology ; Nutritional Status ; Respiratory Function Tests ; Respiratory Muscles - cytology ; Respiratory Muscles - physiology</subject><ispartof>The European respiratory journal, 1998-04, Vol.11 (4), p.906-911</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-a3f5b9033beb1091e9342597739397af75c8f7f66b40e1f892ceb7864571ff763</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2242957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9623696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sauleda, J</creatorcontrib><creatorcontrib>Gea, J</creatorcontrib><creatorcontrib>Orozco-Levi, M</creatorcontrib><creatorcontrib>Corominas, J</creatorcontrib><creatorcontrib>Minguella, J</creatorcontrib><creatorcontrib>Aguar, C</creatorcontrib><creatorcontrib>Broquetas, J</creatorcontrib><creatorcontrib>Agusti, AG</creatorcontrib><title>Structure and function relationships of the respiratory muscles</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Potential relationships between the structure of the diaphragm and external intercostals and several indices of respiratory muscle function, lung function and nutrition in 27 patients (61+/-10 yrs of age) subjected to thoracotomy as a result of a lung neoplasm have been investigated. Prior to surgery the nutritional status of the patients was assessed and lung function (spirometry, lung volumes, transfer factor of the lungs for carbon monoxide, arterial blood gases) and respiratory muscle function (maximal inspiratory pressure (MIP) and diaphragmatic function were measured). Biopsies of the diaphragm (and external intercostals) were obtained during surgery. On average, patients showed mild airflow limitation (forced expiratory volume in one second (FEV1), 70+/-14% of predicted value, FEV1/forced vital capacity (FVC), 70+/-9%) with some air trapping (residual volume (RV), 139+/-50% pred) and normal gas exchange (arterial oxygen tension (Pa,O2), 11.3+/-1.33 kPa (85+/-10 mmHg)) and arterial carbon dioxide tension (Pa,CO2) 5.4+/-0.5 kPa (40.6+/-4 mmHg). MIP was 77+/-25% pred; maximal transdiaphragmatic pressure was 90+/-27 cmH2O. Most morphometric measurements of the diaphragm and external intercostals were within the range of values reported previously in other skeletal muscles. The size of the fibres of these two respiratory muscles was positively related (p<0.05) to MIP (% pred). There were no significant relationships between the structure of both muscles and nutritional status or any index of lung function. In conclusion, in the population studied, the fibre size of the diaphragm and external intercostals appears to relate to their ability to generate force.</description><subject>Biological and medical sciences</subject><subject>Diaphragm - physiology</subject><subject>Humans</subject><subject>Intercostal Muscles - physiology</subject><subject>Investigative techniques of respiratory function</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle Fibers, Skeletal - cytology</subject><subject>Nutritional Status</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Muscles - cytology</subject><subject>Respiratory Muscles - physiology</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1PwyAUhonRzDn9B5r0Qr3rhEKhXBmz-JUs8UK9JpSBZaEfQhuzfy_Nul0B73nOew4vANcILhEq8APkECOO6ZIXUYAkvukJmCPMeYohxKdgPiLpyJyDixC2ECJKMJqBGacZppzOweNn7wfVD14nstkkZmhUb9sm8drJ8RIq24WkNUlf6SiGznrZt36X1ENQTodLcGakC_pqOhfg--X5a_WWrj9e31dP61QRyPpUYpOXcRlc6hJBjjTHJMs5Y5hjzqRhuSoMM5SWBGpkCp4pXbKCkpwhYxjFC3C_9-18-zvo0IvaBqWdk41uhyAYj78kjESQ7EHl2xC8NqLztpZ-JxAUY27ikJvghTjkFttuJv-hrPXm2DQFFeu3U10GJZ3xslE2HLEsIxnPWcTu9lhlf6o_67UItXQumiKh_RYhQcQ47h_DD4GK</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Sauleda, J</creator><creator>Gea, J</creator><creator>Orozco-Levi, M</creator><creator>Corominas, J</creator><creator>Minguella, J</creator><creator>Aguar, C</creator><creator>Broquetas, J</creator><creator>Agusti, AG</creator><general>Eur Respiratory Soc</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Structure and function relationships of the respiratory muscles</title><author>Sauleda, J ; Gea, J ; Orozco-Levi, M ; Corominas, J ; Minguella, J ; Aguar, C ; Broquetas, J ; Agusti, AG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-a3f5b9033beb1091e9342597739397af75c8f7f66b40e1f892ceb7864571ff763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Diaphragm - physiology</topic><topic>Humans</topic><topic>Intercostal Muscles - physiology</topic><topic>Investigative techniques of respiratory function</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle Fibers, Skeletal - cytology</topic><topic>Nutritional Status</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Muscles - cytology</topic><topic>Respiratory Muscles - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sauleda, J</creatorcontrib><creatorcontrib>Gea, J</creatorcontrib><creatorcontrib>Orozco-Levi, M</creatorcontrib><creatorcontrib>Corominas, J</creatorcontrib><creatorcontrib>Minguella, J</creatorcontrib><creatorcontrib>Aguar, C</creatorcontrib><creatorcontrib>Broquetas, J</creatorcontrib><creatorcontrib>Agusti, AG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauleda, J</au><au>Gea, J</au><au>Orozco-Levi, M</au><au>Corominas, J</au><au>Minguella, J</au><au>Aguar, C</au><au>Broquetas, J</au><au>Agusti, AG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure and function relationships of the respiratory muscles</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>11</volume><issue>4</issue><spage>906</spage><epage>911</epage><pages>906-911</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Potential relationships between the structure of the diaphragm and external intercostals and several indices of respiratory muscle function, lung function and nutrition in 27 patients (61+/-10 yrs of age) subjected to thoracotomy as a result of a lung neoplasm have been investigated. Prior to surgery the nutritional status of the patients was assessed and lung function (spirometry, lung volumes, transfer factor of the lungs for carbon monoxide, arterial blood gases) and respiratory muscle function (maximal inspiratory pressure (MIP) and diaphragmatic function were measured). Biopsies of the diaphragm (and external intercostals) were obtained during surgery. On average, patients showed mild airflow limitation (forced expiratory volume in one second (FEV1), 70+/-14% of predicted value, FEV1/forced vital capacity (FVC), 70+/-9%) with some air trapping (residual volume (RV), 139+/-50% pred) and normal gas exchange (arterial oxygen tension (Pa,O2), 11.3+/-1.33 kPa (85+/-10 mmHg)) and arterial carbon dioxide tension (Pa,CO2) 5.4+/-0.5 kPa (40.6+/-4 mmHg). MIP was 77+/-25% pred; maximal transdiaphragmatic pressure was 90+/-27 cmH2O. Most morphometric measurements of the diaphragm and external intercostals were within the range of values reported previously in other skeletal muscles. The size of the fibres of these two respiratory muscles was positively related (p<0.05) to MIP (% pred). There were no significant relationships between the structure of both muscles and nutritional status or any index of lung function. In conclusion, in the population studied, the fibre size of the diaphragm and external intercostals appears to relate to their ability to generate force.</abstract><cop>Leeds</cop><pub>Eur Respiratory Soc</pub><pmid>9623696</pmid><doi>10.1183/09031936.98.11040906</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The European respiratory journal, 1998-04, Vol.11 (4), p.906-911 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Diaphragm - physiology Humans Intercostal Muscles - physiology Investigative techniques of respiratory function Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Muscle Fibers, Skeletal - cytology Nutritional Status Respiratory Function Tests Respiratory Muscles - cytology Respiratory Muscles - physiology |
| title | Structure and function relationships of the respiratory muscles |
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