Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity?
Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as a result of immunosuppressive therapy. Most B-cell lymphomas are associated with Epstein-Barr virus (EBV) infection. We describe a morphologically and clinically distinct group of PTLD in 11 patients that o...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical oncology 1998-06, Vol.16 (6), p.2052-2059 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2059 |
|---|---|
| container_issue | 6 |
| container_start_page | 2052 |
| container_title | Journal of clinical oncology |
| container_volume | 16 |
| creator | LEBLOND, V DAVI, F CHARLOTTE, F DORENT, R BITKER, M.-O SUTTON, L GANDJBAKHCH, I BINET, J.-L RAPHAEL, M |
| description | Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as a result of immunosuppressive therapy. Most B-cell lymphomas are associated with Epstein-Barr virus (EBV) infection. We describe a morphologically and clinically distinct group of PTLD in 11 patients that occurred late after organ transplantation and were not associated with EBV.
There were seven kidney, three heart, and one liver transplant recipients (group I). The clinical manifestations, pathologic findings, treatment, and outcome were compared with those in 21 patients with EBV-associated PTLD treated in our institution (group II). EBV was detected with at least two techniques: Epstein-Barr-encoded RNA (EBER) in situ hybridization with EBER 1 + 2 probes, Southern blotting, and detection of latent membrane protein 1 (LMP1) expression by immunohistochemistry.
The time between transplantation and the diagnosis of lymphoma ranged from 180 to 10,220 days in group I (mean, 2,234; median, 1,800) and from 60 to 2,100 days in group II (mean, 546; median, 180), and was significantly shorter in group II (P = .02). Among 19 tumors diagnosed within 2 years after the graft, 16 were associated with EBV; among 13 tumors diagnosed after more than 2 years, only five were associated with EBV. All of the B-cell PTLDs in group I were classified as monomorphic, meeting the criteria of B diffuse large-cell lymphoma (B-DLCL) with a component of immunoblasts, and genotyping confirmed their monoclonality. Three tumors were T-cell pleomorphic lymphomas. Tumor sites were mainly bone marrow and lymph nodes. Overall median survival was 1 month in group I and 37 months in group II, with two patients still alive in group I and nine in group II. The survival time was significantly longer in group II (P < .01).
EBV-negative PTLD may be a late serious complication of organ transplantation. Half the tumors observed after kidney transplantation in our center were not associated with EBV and emerged after more than 5 years, which suggests the number of EBV-negative PTLDs in organ recipients might increase with time. |
| doi_str_mv | 10.1200/JCO.1998.16.6.2052 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79935878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79935878</sourcerecordid><originalsourceid>FETCH-LOGICAL-c358t-501f5f4851629788c4626ffa7709ac912bfb036d9eb98b1104f738107eb9359a3</originalsourceid><addsrcrecordid>eNpFkFtv1DAQhS0EKkvhDyAh5QHxluBLfOMFlVW5qVJ5AIk3y3HsrqskDh5vq_33eNVV-zQazTlnZj6E3hLcEYrxx5_b645orToiOtFRzOkztCGcylZKzp-jDZaMtkSxvy_RK4BbjEmvGD9DZ1pQQTHboJtfCUrJdoF1sktppsO87tKa0xSDz7bEO9-MEVIefYZmSaWxAMlFW_zY3Meyay5XKD4u7Rebc3MX8x4-NfboKXFxpfFLieXw-TV6EewE_s2pnqM_Xy9_b7-3V9fffmwvrlrHuCotxyTw0CtOBNVSKdfXQ0OwUmJtnSZ0CANmYtR-0GogBPdBMkWwrD3j2rJz9OEht77wb--hmDmC81N9zqc9GKmrTklVhfRB6HICyD6YNcfZ5oMh2BzpmkrXHOkaIowwR7rV9O6Uvh9mPz5aTjjr_P1pbsHZKVSuLsKjjFLBcM-ejtzFm919zN7AbKephlJz69LTvv9H_JDd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79935878</pqid></control><display><type>article</type><title>Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity?</title><source>MEDLINE</source><source>American Society of Clinical Oncology Online Journals</source><source>Journals@Ovid Complete</source><creator>LEBLOND, V ; DAVI, F ; CHARLOTTE, F ; DORENT, R ; BITKER, M.-O ; SUTTON, L ; GANDJBAKHCH, I ; BINET, J.-L ; RAPHAEL, M</creator><creatorcontrib>LEBLOND, V ; DAVI, F ; CHARLOTTE, F ; DORENT, R ; BITKER, M.-O ; SUTTON, L ; GANDJBAKHCH, I ; BINET, J.-L ; RAPHAEL, M</creatorcontrib><description>Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as a result of immunosuppressive therapy. Most B-cell lymphomas are associated with Epstein-Barr virus (EBV) infection. We describe a morphologically and clinically distinct group of PTLD in 11 patients that occurred late after organ transplantation and were not associated with EBV.
There were seven kidney, three heart, and one liver transplant recipients (group I). The clinical manifestations, pathologic findings, treatment, and outcome were compared with those in 21 patients with EBV-associated PTLD treated in our institution (group II). EBV was detected with at least two techniques: Epstein-Barr-encoded RNA (EBER) in situ hybridization with EBER 1 + 2 probes, Southern blotting, and detection of latent membrane protein 1 (LMP1) expression by immunohistochemistry.
The time between transplantation and the diagnosis of lymphoma ranged from 180 to 10,220 days in group I (mean, 2,234; median, 1,800) and from 60 to 2,100 days in group II (mean, 546; median, 180), and was significantly shorter in group II (P = .02). Among 19 tumors diagnosed within 2 years after the graft, 16 were associated with EBV; among 13 tumors diagnosed after more than 2 years, only five were associated with EBV. All of the B-cell PTLDs in group I were classified as monomorphic, meeting the criteria of B diffuse large-cell lymphoma (B-DLCL) with a component of immunoblasts, and genotyping confirmed their monoclonality. Three tumors were T-cell pleomorphic lymphomas. Tumor sites were mainly bone marrow and lymph nodes. Overall median survival was 1 month in group I and 37 months in group II, with two patients still alive in group I and nine in group II. The survival time was significantly longer in group II (P < .01).
EBV-negative PTLD may be a late serious complication of organ transplantation. Half the tumors observed after kidney transplantation in our center were not associated with EBV and emerged after more than 5 years, which suggests the number of EBV-negative PTLDs in organ recipients might increase with time.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.1998.16.6.2052</identifier><identifier>PMID: 9626203</identifier><language>eng</language><publisher>Baltimore, MD: American Society of Clinical Oncology</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Blotting, Southern ; Female ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - isolation & purification ; Humans ; Immunoglobulins - genetics ; Immunohistochemistry ; Immunosuppression - adverse effects ; In Situ Hybridization ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes - chemistry ; Lymphoproliferative Disorders - diagnosis ; Lymphoproliferative Disorders - etiology ; Lymphoproliferative Disorders - mortality ; Lymphoproliferative Disorders - virology ; Male ; Medical sciences ; Middle Aged ; Organ Transplantation ; Receptors, Antigen, T-Cell - genetics ; RNA, Messenger - analysis ; RNA, Viral - analysis ; Survival Rate</subject><ispartof>Journal of clinical oncology, 1998-06, Vol.16 (6), p.2052-2059</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-501f5f4851629788c4626ffa7709ac912bfb036d9eb98b1104f738107eb9359a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3730,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2263043$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9626203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEBLOND, V</creatorcontrib><creatorcontrib>DAVI, F</creatorcontrib><creatorcontrib>CHARLOTTE, F</creatorcontrib><creatorcontrib>DORENT, R</creatorcontrib><creatorcontrib>BITKER, M.-O</creatorcontrib><creatorcontrib>SUTTON, L</creatorcontrib><creatorcontrib>GANDJBAKHCH, I</creatorcontrib><creatorcontrib>BINET, J.-L</creatorcontrib><creatorcontrib>RAPHAEL, M</creatorcontrib><title>Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity?</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as a result of immunosuppressive therapy. Most B-cell lymphomas are associated with Epstein-Barr virus (EBV) infection. We describe a morphologically and clinically distinct group of PTLD in 11 patients that occurred late after organ transplantation and were not associated with EBV.
There were seven kidney, three heart, and one liver transplant recipients (group I). The clinical manifestations, pathologic findings, treatment, and outcome were compared with those in 21 patients with EBV-associated PTLD treated in our institution (group II). EBV was detected with at least two techniques: Epstein-Barr-encoded RNA (EBER) in situ hybridization with EBER 1 + 2 probes, Southern blotting, and detection of latent membrane protein 1 (LMP1) expression by immunohistochemistry.
The time between transplantation and the diagnosis of lymphoma ranged from 180 to 10,220 days in group I (mean, 2,234; median, 1,800) and from 60 to 2,100 days in group II (mean, 546; median, 180), and was significantly shorter in group II (P = .02). Among 19 tumors diagnosed within 2 years after the graft, 16 were associated with EBV; among 13 tumors diagnosed after more than 2 years, only five were associated with EBV. All of the B-cell PTLDs in group I were classified as monomorphic, meeting the criteria of B diffuse large-cell lymphoma (B-DLCL) with a component of immunoblasts, and genotyping confirmed their monoclonality. Three tumors were T-cell pleomorphic lymphomas. Tumor sites were mainly bone marrow and lymph nodes. Overall median survival was 1 month in group I and 37 months in group II, with two patients still alive in group I and nine in group II. The survival time was significantly longer in group II (P < .01).
EBV-negative PTLD may be a late serious complication of organ transplantation. Half the tumors observed after kidney transplantation in our center were not associated with EBV and emerged after more than 5 years, which suggests the number of EBV-negative PTLDs in organ recipients might increase with time.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Immunoglobulins - genetics</subject><subject>Immunohistochemistry</subject><subject>Immunosuppression - adverse effects</subject><subject>In Situ Hybridization</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocytes - chemistry</subject><subject>Lymphoproliferative Disorders - diagnosis</subject><subject>Lymphoproliferative Disorders - etiology</subject><subject>Lymphoproliferative Disorders - mortality</subject><subject>Lymphoproliferative Disorders - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organ Transplantation</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Viral - analysis</subject><subject>Survival Rate</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtv1DAQhS0EKkvhDyAh5QHxluBLfOMFlVW5qVJ5AIk3y3HsrqskDh5vq_33eNVV-zQazTlnZj6E3hLcEYrxx5_b645orToiOtFRzOkztCGcylZKzp-jDZaMtkSxvy_RK4BbjEmvGD9DZ1pQQTHboJtfCUrJdoF1sktppsO87tKa0xSDz7bEO9-MEVIefYZmSaWxAMlFW_zY3Meyay5XKD4u7Rebc3MX8x4-NfboKXFxpfFLieXw-TV6EewE_s2pnqM_Xy9_b7-3V9fffmwvrlrHuCotxyTw0CtOBNVSKdfXQ0OwUmJtnSZ0CANmYtR-0GogBPdBMkWwrD3j2rJz9OEht77wb--hmDmC81N9zqc9GKmrTklVhfRB6HICyD6YNcfZ5oMh2BzpmkrXHOkaIowwR7rV9O6Uvh9mPz5aTjjr_P1pbsHZKVSuLsKjjFLBcM-ejtzFm919zN7AbKephlJz69LTvv9H_JDd</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>LEBLOND, V</creator><creator>DAVI, F</creator><creator>CHARLOTTE, F</creator><creator>DORENT, R</creator><creator>BITKER, M.-O</creator><creator>SUTTON, L</creator><creator>GANDJBAKHCH, I</creator><creator>BINET, J.-L</creator><creator>RAPHAEL, M</creator><general>American Society of Clinical Oncology</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980601</creationdate><title>Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity?</title><author>LEBLOND, V ; DAVI, F ; CHARLOTTE, F ; DORENT, R ; BITKER, M.-O ; SUTTON, L ; GANDJBAKHCH, I ; BINET, J.-L ; RAPHAEL, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-501f5f4851629788c4626ffa7709ac912bfb036d9eb98b1104f738107eb9359a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Immunoglobulins - genetics</topic><topic>Immunohistochemistry</topic><topic>Immunosuppression - adverse effects</topic><topic>In Situ Hybridization</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocytes - chemistry</topic><topic>Lymphoproliferative Disorders - diagnosis</topic><topic>Lymphoproliferative Disorders - etiology</topic><topic>Lymphoproliferative Disorders - mortality</topic><topic>Lymphoproliferative Disorders - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Organ Transplantation</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Viral - analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEBLOND, V</creatorcontrib><creatorcontrib>DAVI, F</creatorcontrib><creatorcontrib>CHARLOTTE, F</creatorcontrib><creatorcontrib>DORENT, R</creatorcontrib><creatorcontrib>BITKER, M.-O</creatorcontrib><creatorcontrib>SUTTON, L</creatorcontrib><creatorcontrib>GANDJBAKHCH, I</creatorcontrib><creatorcontrib>BINET, J.-L</creatorcontrib><creatorcontrib>RAPHAEL, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEBLOND, V</au><au>DAVI, F</au><au>CHARLOTTE, F</au><au>DORENT, R</au><au>BITKER, M.-O</au><au>SUTTON, L</au><au>GANDJBAKHCH, I</au><au>BINET, J.-L</au><au>RAPHAEL, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity?</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>16</volume><issue>6</issue><spage>2052</spage><epage>2059</epage><pages>2052-2059</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>Organ recipients are at a high risk of posttransplant lymphoproliferative disorders (PTLD) as a result of immunosuppressive therapy. Most B-cell lymphomas are associated with Epstein-Barr virus (EBV) infection. We describe a morphologically and clinically distinct group of PTLD in 11 patients that occurred late after organ transplantation and were not associated with EBV.
There were seven kidney, three heart, and one liver transplant recipients (group I). The clinical manifestations, pathologic findings, treatment, and outcome were compared with those in 21 patients with EBV-associated PTLD treated in our institution (group II). EBV was detected with at least two techniques: Epstein-Barr-encoded RNA (EBER) in situ hybridization with EBER 1 + 2 probes, Southern blotting, and detection of latent membrane protein 1 (LMP1) expression by immunohistochemistry.
The time between transplantation and the diagnosis of lymphoma ranged from 180 to 10,220 days in group I (mean, 2,234; median, 1,800) and from 60 to 2,100 days in group II (mean, 546; median, 180), and was significantly shorter in group II (P = .02). Among 19 tumors diagnosed within 2 years after the graft, 16 were associated with EBV; among 13 tumors diagnosed after more than 2 years, only five were associated with EBV. All of the B-cell PTLDs in group I were classified as monomorphic, meeting the criteria of B diffuse large-cell lymphoma (B-DLCL) with a component of immunoblasts, and genotyping confirmed their monoclonality. Three tumors were T-cell pleomorphic lymphomas. Tumor sites were mainly bone marrow and lymph nodes. Overall median survival was 1 month in group I and 37 months in group II, with two patients still alive in group I and nine in group II. The survival time was significantly longer in group II (P < .01).
EBV-negative PTLD may be a late serious complication of organ transplantation. Half the tumors observed after kidney transplantation in our center were not associated with EBV and emerged after more than 5 years, which suggests the number of EBV-negative PTLDs in organ recipients might increase with time.</abstract><cop>Baltimore, MD</cop><pub>American Society of Clinical Oncology</pub><pmid>9626203</pmid><doi>10.1200/JCO.1998.16.6.2052</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-183X |
| ispartof | Journal of clinical oncology, 1998-06, Vol.16 (6), p.2052-2059 |
| issn | 0732-183X 1527-7755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79935878 |
| source | MEDLINE; American Society of Clinical Oncology Online Journals; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Biological and medical sciences Blotting, Southern Female Hematologic and hematopoietic diseases Herpesvirus 4, Human - isolation & purification Humans Immunoglobulins - genetics Immunohistochemistry Immunosuppression - adverse effects In Situ Hybridization Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes - chemistry Lymphoproliferative Disorders - diagnosis Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - mortality Lymphoproliferative Disorders - virology Male Medical sciences Middle Aged Organ Transplantation Receptors, Antigen, T-Cell - genetics RNA, Messenger - analysis RNA, Viral - analysis Survival Rate |
| title | Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T17%3A13%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Posttransplant%20lymphoproliferative%20disorders%20not%20associated%20with%20Epstein-Barr%20virus:%20a%20distinct%20entity?&rft.jtitle=Journal%20of%20clinical%20oncology&rft.au=LEBLOND,%20V&rft.date=1998-06-01&rft.volume=16&rft.issue=6&rft.spage=2052&rft.epage=2059&rft.pages=2052-2059&rft.issn=0732-183X&rft.eissn=1527-7755&rft_id=info:doi/10.1200/JCO.1998.16.6.2052&rft_dat=%3Cproquest_cross%3E79935878%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79935878&rft_id=info:pmid/9626203&rfr_iscdi=true |