Inhibition of platelet serotonin uptake by cytochrome P450 inhibitors miconazole and econazole
Serotonin uptake in human platelets was inhibited by cytochrome P450 inhibitors such as miconazole and econazole but not clotrimazole. There was a correlation between inhibition of serotonin uptake and inhibition of imipramine binding, suggesting that these P450 inhibitors may inhibit serotonin upta...
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| Veröffentlicht in: | Life sciences (1973) 1998, Vol.62 (24), p.2203-2208 |
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| container_title | Life sciences (1973) |
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| creator | Helmeste, Daiga M. Tang, Siu Wa Vu, Ryan |
| description | Serotonin uptake in human platelets was inhibited by cytochrome P450 inhibitors such as miconazole and econazole but not clotrimazole. There was a correlation between inhibition of serotonin uptake and inhibition of imipramine binding, suggesting that these P450 inhibitors may inhibit serotonin uptake via direct binding to the transporter. P450 inhibitor effects on serotonin uptake did not seem to be related to the effects of these compounds on intracellular calcium mobilization. Additionally, nitric oxide pathway stimulation does not appear to be involved. |
| doi_str_mv | 10.1016/S0024-3205(98)00198-2 |
| format | Article |
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There was a correlation between inhibition of serotonin uptake and inhibition of imipramine binding, suggesting that these P450 inhibitors may inhibit serotonin uptake via direct binding to the transporter. P450 inhibitor effects on serotonin uptake did not seem to be related to the effects of these compounds on intracellular calcium mobilization. Additionally, nitric oxide pathway stimulation does not appear to be involved.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(98)00198-2</identifier><identifier>PMID: 9627079</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Benzoflavones - pharmacology ; beta-Naphthoflavone - pharmacology ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; calcium ; Calcium - metabolism ; Clotrimazole - pharmacology ; Cytochrome P-450 Enzyme Inhibitors ; cytochrome P450 inhibitors ; Drug Combinations ; Drugs, Chinese Herbal - pharmacology ; Econazole - pharmacology ; Enzyme Inhibitors - pharmacology ; human platelets ; Humans ; imipramine ; Miconazole - pharmacology ; Serotonin - metabolism ; serotonin uptake</subject><ispartof>Life sciences (1973), 1998, Vol.62 (24), p.2203-2208</ispartof><rights>1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-acf71d389e117b36d08e0f4c89ff615dd764dd0df0c7666e9f611eac9f0627513</citedby><cites>FETCH-LOGICAL-c360t-acf71d389e117b36d08e0f4c89ff615dd764dd0df0c7666e9f611eac9f0627513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320598001982$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9627079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helmeste, Daiga M.</creatorcontrib><creatorcontrib>Tang, Siu Wa</creatorcontrib><creatorcontrib>Vu, Ryan</creatorcontrib><title>Inhibition of platelet serotonin uptake by cytochrome P450 inhibitors miconazole and econazole</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Serotonin uptake in human platelets was inhibited by cytochrome P450 inhibitors such as miconazole and econazole but not clotrimazole. There was a correlation between inhibition of serotonin uptake and inhibition of imipramine binding, suggesting that these P450 inhibitors may inhibit serotonin uptake via direct binding to the transporter. P450 inhibitor effects on serotonin uptake did not seem to be related to the effects of these compounds on intracellular calcium mobilization. Additionally, nitric oxide pathway stimulation does not appear to be involved.</description><subject>Benzoflavones - pharmacology</subject><subject>beta-Naphthoflavone - pharmacology</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Clotrimazole - pharmacology</subject><subject>Cytochrome P-450 Enzyme Inhibitors</subject><subject>cytochrome P450 inhibitors</subject><subject>Drug Combinations</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Econazole - pharmacology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>human platelets</subject><subject>Humans</subject><subject>imipramine</subject><subject>Miconazole - pharmacology</subject><subject>Serotonin - metabolism</subject><subject>serotonin uptake</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLLDEQhYMoOj5-gpCVeBetlX4knZWIXB8gKKhbQyapYLS7MyYZYfz19jijW1dFVZ1Th_oIOWRwwoDx0weAsi6qEppj2f4DYLItyg0yYa2QBfCKbZLJr2SH7Kb0CgBNI6ptsi15KUDICXm-GV781GcfBhocnXU6Y4eZJowhh8EPdD7L-g3pdEHNIgfzEkOP9L5ugPqVNcREe2_CoD9Dh1QPluJPt0-2nO4SHqzrHnm6_P94cV3c3l3dXJzfFqbikAttnGC2aiUyJqYVt9AiuNq00jnOGmsFr60F68AIzjnKccpQG-lgfKRh1R45Wt2dxfA-x5RV75PBrtMDhnlSQsqqBr4UNiuhiSGliE7Nou91XCgGaslVfXNVS2hKtuqbqypH3-E6YD7t0f661iDH_dlqj-OXHx6jSsbjYND6iCYrG_wfCV_-Qoiz</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Helmeste, Daiga M.</creator><creator>Tang, Siu Wa</creator><creator>Vu, Ryan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Inhibition of platelet serotonin uptake by cytochrome P450 inhibitors miconazole and econazole</title><author>Helmeste, Daiga M. ; Tang, Siu Wa ; Vu, Ryan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-acf71d389e117b36d08e0f4c89ff615dd764dd0df0c7666e9f611eac9f0627513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Benzoflavones - pharmacology</topic><topic>beta-Naphthoflavone - pharmacology</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Clotrimazole - pharmacology</topic><topic>Cytochrome P-450 Enzyme Inhibitors</topic><topic>cytochrome P450 inhibitors</topic><topic>Drug Combinations</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Econazole - pharmacology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>human platelets</topic><topic>Humans</topic><topic>imipramine</topic><topic>Miconazole - pharmacology</topic><topic>Serotonin - metabolism</topic><topic>serotonin uptake</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helmeste, Daiga M.</creatorcontrib><creatorcontrib>Tang, Siu Wa</creatorcontrib><creatorcontrib>Vu, Ryan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helmeste, Daiga M.</au><au>Tang, Siu Wa</au><au>Vu, Ryan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of platelet serotonin uptake by cytochrome P450 inhibitors miconazole and econazole</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1998</date><risdate>1998</risdate><volume>62</volume><issue>24</issue><spage>2203</spage><epage>2208</epage><pages>2203-2208</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Serotonin uptake in human platelets was inhibited by cytochrome P450 inhibitors such as miconazole and econazole but not clotrimazole. There was a correlation between inhibition of serotonin uptake and inhibition of imipramine binding, suggesting that these P450 inhibitors may inhibit serotonin uptake via direct binding to the transporter. P450 inhibitor effects on serotonin uptake did not seem to be related to the effects of these compounds on intracellular calcium mobilization. Additionally, nitric oxide pathway stimulation does not appear to be involved.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9627079</pmid><doi>10.1016/S0024-3205(98)00198-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Life sciences (1973), 1998, Vol.62 (24), p.2203-2208 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Benzoflavones - pharmacology beta-Naphthoflavone - pharmacology Blood Platelets - drug effects Blood Platelets - metabolism calcium Calcium - metabolism Clotrimazole - pharmacology Cytochrome P-450 Enzyme Inhibitors cytochrome P450 inhibitors Drug Combinations Drugs, Chinese Herbal - pharmacology Econazole - pharmacology Enzyme Inhibitors - pharmacology human platelets Humans imipramine Miconazole - pharmacology Serotonin - metabolism serotonin uptake |
| title | Inhibition of platelet serotonin uptake by cytochrome P450 inhibitors miconazole and econazole |
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