Ritodrine sulphation in the human liver and duodenal mucosa : interindividual variability

The beta2-adrenoceptor agonist ritodrine has a bioavailability of 30% due to its presystemic metabolism and sulphation is an important metabolic route. The interindividual variability in the rate of ritodrine sulphation in 100 specimens of human liver and duodenum is reported. The final concentratio...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1998-01, Vol.23 (1), p.67-74
Hauptverfasser:	PACIFICI, G. M, QUILICI, M. C, GIULIANETTI, B, SPISNI, R, NERVI, M, GIULIANI, L, GOMENI, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - metabolism Adult Aged Aged, 80 and over Biological and medical sciences Duodenum - metabolism Female Genital system. Reproduction Humans Intestinal Mucosa - metabolism Liver - metabolism Male Medical sciences Middle Aged Pharmacology. Drug treatments Ritodrine - metabolism Sulfotransferases - physiology
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