Microtubule-associated protein 1a is involved in the early development of the rat spinal cord
The expression of microtubule-associated protein 1a (MAP1a) in the developing rat spinal cord was studied using the monoclonal antibody BW6. Immunoblots of microtubule preparations revealed the presence of MAP1a in spinal cord tissue of rats aged embryonal day 16 and postnatal day 0. The spinal cord...
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| Veröffentlicht in: | Neuroscience letters 1998-04, Vol.246 (2), p.81-84 |
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| creator | Oudega, M. Touri, F. Deenen, M.G.M. Riederer, B.M. Marani, E. |
| description | The expression of microtubule-associated protein 1a (MAP1a) in the developing rat spinal cord was studied using the monoclonal antibody BW6. Immunoblots of microtubule preparations revealed the presence of MAP1a in spinal cord tissue of rats aged embryonal day 16 and postnatal day 0. The spinal cord matrix layer, between embryonal days 12–17, displayed a pattern of MAP1a-positive processes, horizontally oriented in between the membrane limitans interna and externa. The mantle layer stained intensely for MAP1a between embryonal day 12 and postnatal day 2. MAP1a was found in neuronal cell bodies, axons and dendrites, located mainly in the ventral and intermediate mantle layer. In the marginal layer, MAP1a-positive axons could be observed between embryonal days 14–18. During further development, the intensity of the MAP1a staining in the spinal columns gradually decreased. These expression patterns indicate an involvement of MAP1a in the proliferation and differentiation of neuroblasts, and the maturation of the long spinal fiber sytems, i.e. early events in spinal cord development. |
| doi_str_mv | 10.1016/S0304-3940(98)00232-8 |
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Immunoblots of microtubule preparations revealed the presence of MAP1a in spinal cord tissue of rats aged embryonal day 16 and postnatal day 0. The spinal cord matrix layer, between embryonal days 12–17, displayed a pattern of MAP1a-positive processes, horizontally oriented in between the membrane limitans interna and externa. The mantle layer stained intensely for MAP1a between embryonal day 12 and postnatal day 2. MAP1a was found in neuronal cell bodies, axons and dendrites, located mainly in the ventral and intermediate mantle layer. In the marginal layer, MAP1a-positive axons could be observed between embryonal days 14–18. During further development, the intensity of the MAP1a staining in the spinal columns gradually decreased. 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Psychology ; Gene Expression Regulation, Developmental ; Gestational Age ; Immunohistochemistry ; Microtubule-associated protein ; Microtubule-Associated Proteins - biosynthesis ; Molecular embryology ; Ontogeny ; Rats ; Rats, Wistar ; Spinal Cord - embryology ; Spinal Cord - growth & development ; Spinal Cord - metabolism ; Subtype ; Vimentin</subject><ispartof>Neuroscience letters, 1998-04, Vol.246 (2), p.81-84</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-a96b25a52586e1d4342410d780cdc5ff2ef2026ef9806b55aa9190ce06cd10373</citedby><cites>FETCH-LOGICAL-c467t-a96b25a52586e1d4342410d780cdc5ff2ef2026ef9806b55aa9190ce06cd10373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(98)00232-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2242182$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9627185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oudega, M.</creatorcontrib><creatorcontrib>Touri, F.</creatorcontrib><creatorcontrib>Deenen, M.G.M.</creatorcontrib><creatorcontrib>Riederer, B.M.</creatorcontrib><creatorcontrib>Marani, E.</creatorcontrib><title>Microtubule-associated protein 1a is involved in the early development of the rat spinal cord</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The expression of microtubule-associated protein 1a (MAP1a) in the developing rat spinal cord was studied using the monoclonal antibody BW6. Immunoblots of microtubule preparations revealed the presence of MAP1a in spinal cord tissue of rats aged embryonal day 16 and postnatal day 0. The spinal cord matrix layer, between embryonal days 12–17, displayed a pattern of MAP1a-positive processes, horizontally oriented in between the membrane limitans interna and externa. The mantle layer stained intensely for MAP1a between embryonal day 12 and postnatal day 2. MAP1a was found in neuronal cell bodies, axons and dendrites, located mainly in the ventral and intermediate mantle layer. In the marginal layer, MAP1a-positive axons could be observed between embryonal days 14–18. During further development, the intensity of the MAP1a staining in the spinal columns gradually decreased. 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Psychology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gestational Age</subject><subject>Immunohistochemistry</subject><subject>Microtubule-associated protein</subject><subject>Microtubule-Associated Proteins - biosynthesis</subject><subject>Molecular embryology</subject><subject>Ontogeny</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spinal Cord - embryology</subject><subject>Spinal Cord - growth & development</subject><subject>Spinal Cord - metabolism</subject><subject>Subtype</subject><subject>Vimentin</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo67j6ExZyENFDu5V0Pk8iy64KK3tQjxIySTVGMt1j0j2w_97MB3PdU-B9n0oVDyFXDD4yYOr6B_Qgut4KeG_NBwDe8848IytmNO-01fw5WZ2Rl-RVrX8BQDIpLsiFVVwzI1fk9_cUyjQv6yVj52udQvIzRrptIaaRMk9TpWncTXnX4pbMf5CiL_mRRtxhnrYbHGc6DYei-JnWbRp9pmEq8TV5Mfhc8c3pvSS_7m5_3nzt7h--fLv5fN8FofTceavWXHrJpVHIougFFwyiNhBikMPAceDAFQ7WgFpL6b1lFgKCCpFBr_tL8u74bzv734J1dptUA-bsR5yW6rS1PdPCPAkyJbgEAw2UR7DZqbXg4LYlbXx5dAzc3r87-Hd7uc4ad_Dv9guuTguW9QbjeeokvPVvT72vweeh-DGkesY4F5wZ3rBPRwybtV3C4mpIOAaMqWCYXZzSE4f8B59roSs</recordid><startdate>19980424</startdate><enddate>19980424</enddate><creator>Oudega, M.</creator><creator>Touri, F.</creator><creator>Deenen, M.G.M.</creator><creator>Riederer, B.M.</creator><creator>Marani, E.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980424</creationdate><title>Microtubule-associated protein 1a is involved in the early development of the rat spinal cord</title><author>Oudega, M. ; Touri, F. ; Deenen, M.G.M. ; Riederer, B.M. ; Marani, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-a96b25a52586e1d4342410d780cdc5ff2ef2026ef9806b55aa9190ce06cd10373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cytoskeleton</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gestational Age</topic><topic>Immunohistochemistry</topic><topic>Microtubule-associated protein</topic><topic>Microtubule-Associated Proteins - biosynthesis</topic><topic>Molecular embryology</topic><topic>Ontogeny</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spinal Cord - embryology</topic><topic>Spinal Cord - growth & development</topic><topic>Spinal Cord - metabolism</topic><topic>Subtype</topic><topic>Vimentin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oudega, M.</creatorcontrib><creatorcontrib>Touri, F.</creatorcontrib><creatorcontrib>Deenen, M.G.M.</creatorcontrib><creatorcontrib>Riederer, B.M.</creatorcontrib><creatorcontrib>Marani, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oudega, M.</au><au>Touri, F.</au><au>Deenen, M.G.M.</au><au>Riederer, B.M.</au><au>Marani, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microtubule-associated protein 1a is involved in the early development of the rat spinal cord</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1998-04-24</date><risdate>1998</risdate><volume>246</volume><issue>2</issue><spage>81</spage><epage>84</epage><pages>81-84</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The expression of microtubule-associated protein 1a (MAP1a) in the developing rat spinal cord was studied using the monoclonal antibody BW6. Immunoblots of microtubule preparations revealed the presence of MAP1a in spinal cord tissue of rats aged embryonal day 16 and postnatal day 0. The spinal cord matrix layer, between embryonal days 12–17, displayed a pattern of MAP1a-positive processes, horizontally oriented in between the membrane limitans interna and externa. The mantle layer stained intensely for MAP1a between embryonal day 12 and postnatal day 2. MAP1a was found in neuronal cell bodies, axons and dendrites, located mainly in the ventral and intermediate mantle layer. In the marginal layer, MAP1a-positive axons could be observed between embryonal days 14–18. During further development, the intensity of the MAP1a staining in the spinal columns gradually decreased. These expression patterns indicate an involvement of MAP1a in the proliferation and differentiation of neuroblasts, and the maturation of the long spinal fiber sytems, i.e. early events in spinal cord development.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9627185</pmid><doi>10.1016/S0304-3940(98)00232-8</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroscience letters, 1998-04, Vol.246 (2), p.81-84 |
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| subjects | Aging - metabolism Animals Animals, Newborn Biological and medical sciences Central nervous system Cytoskeleton Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Gestational Age Immunohistochemistry Microtubule-associated protein Microtubule-Associated Proteins - biosynthesis Molecular embryology Ontogeny Rats Rats, Wistar Spinal Cord - embryology Spinal Cord - growth & development Spinal Cord - metabolism Subtype Vimentin |
| title | Microtubule-associated protein 1a is involved in the early development of the rat spinal cord |
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