Structural Analysis of Thrombin Complexed with Potent Inhibitors Incorporating a Phenyl Group as a Peptide Mimetic and Aminopyridines as Guanidine Substitutes

The structure of the noncovalent complex of human α-thrombin with a nonpeptide inhibitor containing a central phenyl scaffold, N-[2-[5-methyl-3-(2-chlorophenylsulfonyloxy)phenoxy]ethyl]-N-methyl-4-aminopyridine (1), has been determined to 2.20 Å resolution. In addition, the thrombin-bound structures...

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