Lymph node metastasis from melanoma with an unknown primary site
Twenty‐six patients, treated surgically between 1961 and 1986 because of lymph node metastasis from melanoma with an unknown primary, were analysed. Six patients had a history of spontaneous regression of a skin lesion. Following node dissection, the overall actuarial disease‐free survival rate was...
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| Veröffentlicht in: | British journal of surgery 1990-06, Vol.77 (6), p.665-668 |
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| container_title | British journal of surgery |
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| creator | Jonk, A. Kroon, B. B. R. Rümke, Ph Mooi, W. J. Hart, A. A. M. Van Dongen, J. A. |
| description | Twenty‐six patients, treated surgically between 1961 and 1986 because of lymph node metastasis from melanoma with an unknown primary, were analysed. Six patients had a history of spontaneous regression of a skin lesion. Following node dissection, the overall actuarial disease‐free survival rate was 49 per cent, after both 5 and 10 years. When considered as single factors, female (versus male), one lymph node involved (versus more than one node involved) and site of metastasis in the groin or axilla (versus the neck) were found to have significantly favourable effects on prognosis with 5‐year survival rates of 82 per cent (25 per cent), 82 per cent (27 per cent) and 80 per cent (11 per cent) respectively. However, at multifactorial analysis only the site of cervical metastases maintained a significant influence on survival (P = 0·005). As survival in this series is comparable with, or even better than, that of adequately treated patients with lymph node metastasis from a known primary melanoma, a radical node dissection is essential also in these patients. |
| doi_str_mv | 10.1002/bjs.1800770625 |
| format | Article |
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B. R. ; Rümke, Ph ; Mooi, W. J. ; Hart, A. A. M. ; Van Dongen, J. A.</creator><creatorcontrib>Jonk, A. ; Kroon, B. B. R. ; Rümke, Ph ; Mooi, W. J. ; Hart, A. A. M. ; Van Dongen, J. A.</creatorcontrib><description>Twenty‐six patients, treated surgically between 1961 and 1986 because of lymph node metastasis from melanoma with an unknown primary, were analysed. Six patients had a history of spontaneous regression of a skin lesion. Following node dissection, the overall actuarial disease‐free survival rate was 49 per cent, after both 5 and 10 years. When considered as single factors, female (versus male), one lymph node involved (versus more than one node involved) and site of metastasis in the groin or axilla (versus the neck) were found to have significantly favourable effects on prognosis with 5‐year survival rates of 82 per cent (25 per cent), 82 per cent (27 per cent) and 80 per cent (11 per cent) respectively. However, at multifactorial analysis only the site of cervical metastases maintained a significant influence on survival (P = 0·005). As survival in this series is comparable with, or even better than, that of adequately treated patients with lymph node metastasis from a known primary melanoma, a radical node dissection is essential also in these patients.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800770625</identifier><identifier>PMID: 2383736</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; lymph node metastasis ; Lymphatic Metastasis - pathology ; Male ; melanoma ; Melanoma - mortality ; Melanoma - pathology ; Middle Aged ; Neck ; Neoplasm Regression, Spontaneous ; Neoplasms, Unknown Primary - pathology ; Prognosis ; Regression Analysis ; Skin - pathology ; spontaneous regression ; Survival Rate ; Unknown primary</subject><ispartof>British journal of surgery, 1990-06, Vol.77 (6), p.665-668</ispartof><rights>Copyright © 1990 British Journal of Surgery Society Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3395-fbc5282bce1452d58e9890c4ac61409c844ca281f65b4d0fde47ae1ee4dd28b63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800770625$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800770625$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2383736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jonk, A.</creatorcontrib><creatorcontrib>Kroon, B. B. R.</creatorcontrib><creatorcontrib>Rümke, Ph</creatorcontrib><creatorcontrib>Mooi, W. J.</creatorcontrib><creatorcontrib>Hart, A. A. M.</creatorcontrib><creatorcontrib>Van Dongen, J. A.</creatorcontrib><title>Lymph node metastasis from melanoma with an unknown primary site</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Twenty‐six patients, treated surgically between 1961 and 1986 because of lymph node metastasis from melanoma with an unknown primary, were analysed. Six patients had a history of spontaneous regression of a skin lesion. Following node dissection, the overall actuarial disease‐free survival rate was 49 per cent, after both 5 and 10 years. When considered as single factors, female (versus male), one lymph node involved (versus more than one node involved) and site of metastasis in the groin or axilla (versus the neck) were found to have significantly favourable effects on prognosis with 5‐year survival rates of 82 per cent (25 per cent), 82 per cent (27 per cent) and 80 per cent (11 per cent) respectively. However, at multifactorial analysis only the site of cervical metastases maintained a significant influence on survival (P = 0·005). As survival in this series is comparable with, or even better than, that of adequately treated patients with lymph node metastasis from a known primary melanoma, a radical node dissection is essential also in these patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Humans</subject><subject>lymph node metastasis</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>melanoma</subject><subject>Melanoma - mortality</subject><subject>Melanoma - pathology</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Neoplasm Regression, Spontaneous</subject><subject>Neoplasms, Unknown Primary - pathology</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Skin - pathology</subject><subject>spontaneous regression</subject><subject>Survival Rate</subject><subject>Unknown primary</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUMtOwzAQtBColMKVG5JP3FL8tnMDKiigCg7ldbMcx1HT5lHiRKV_j1GjVlpptTs7u7MDwCVGY4wQuUmWfowVQlIiQfgRGGIqeESwUMdgiEI_wpTQU3Dm_RIhTBEnAzAgVFFJxRDczrblegGrOnWwdK3xIXIPs6YuQ12Yqi4N3OTtApoKdtWqqjcVXDd5aZot9HnrzsFJZgrvLvo8Ah-PD--Tp2j2Nn2e3M0iS2nMoyyxnCiSWIcZJylXLlYxssxYgRmKrWLMGqJwJnjCUpSljknjsHMsTYlKBB2B693edVP_dM63usy9dUWQ6OrOaxnH4TeKw-BVP9glpUt1L1b3Lwc83uGbvHDbPYyR_vdTBz_1wU99_zI_VIEb7bi5b93vnmualRaSSq6_XqfhkJxgOv_Wn_QPUex4Mg</recordid><startdate>199006</startdate><enddate>199006</enddate><creator>Jonk, A.</creator><creator>Kroon, B. B. R.</creator><creator>Rümke, Ph</creator><creator>Mooi, W. J.</creator><creator>Hart, A. A. M.</creator><creator>Van Dongen, J. A.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199006</creationdate><title>Lymph node metastasis from melanoma with an unknown primary site</title><author>Jonk, A. ; Kroon, B. B. R. ; Rümke, Ph ; Mooi, W. J. ; Hart, A. A. M. ; Van Dongen, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3395-fbc5282bce1452d58e9890c4ac61409c844ca281f65b4d0fde47ae1ee4dd28b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Humans</topic><topic>lymph node metastasis</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>melanoma</topic><topic>Melanoma - mortality</topic><topic>Melanoma - pathology</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Neoplasm Regression, Spontaneous</topic><topic>Neoplasms, Unknown Primary - pathology</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Skin - pathology</topic><topic>spontaneous regression</topic><topic>Survival Rate</topic><topic>Unknown primary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jonk, A.</creatorcontrib><creatorcontrib>Kroon, B. B. R.</creatorcontrib><creatorcontrib>Rümke, Ph</creatorcontrib><creatorcontrib>Mooi, W. J.</creatorcontrib><creatorcontrib>Hart, A. A. M.</creatorcontrib><creatorcontrib>Van Dongen, J. A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonk, A.</au><au>Kroon, B. B. R.</au><au>Rümke, Ph</au><au>Mooi, W. J.</au><au>Hart, A. A. M.</au><au>Van Dongen, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymph node metastasis from melanoma with an unknown primary site</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1990-06</date><risdate>1990</risdate><volume>77</volume><issue>6</issue><spage>665</spage><epage>668</epage><pages>665-668</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>Twenty‐six patients, treated surgically between 1961 and 1986 because of lymph node metastasis from melanoma with an unknown primary, were analysed. Six patients had a history of spontaneous regression of a skin lesion. Following node dissection, the overall actuarial disease‐free survival rate was 49 per cent, after both 5 and 10 years. When considered as single factors, female (versus male), one lymph node involved (versus more than one node involved) and site of metastasis in the groin or axilla (versus the neck) were found to have significantly favourable effects on prognosis with 5‐year survival rates of 82 per cent (25 per cent), 82 per cent (27 per cent) and 80 per cent (11 per cent) respectively. However, at multifactorial analysis only the site of cervical metastases maintained a significant influence on survival (P = 0·005). As survival in this series is comparable with, or even better than, that of adequately treated patients with lymph node metastasis from a known primary melanoma, a radical node dissection is essential also in these patients.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>2383736</pmid><doi>10.1002/bjs.1800770625</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | British journal of surgery, 1990-06, Vol.77 (6), p.665-668 |
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| language | eng |
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| subjects | Adult Aged Aged, 80 and over Female Humans lymph node metastasis Lymphatic Metastasis - pathology Male melanoma Melanoma - mortality Melanoma - pathology Middle Aged Neck Neoplasm Regression, Spontaneous Neoplasms, Unknown Primary - pathology Prognosis Regression Analysis Skin - pathology spontaneous regression Survival Rate Unknown primary |
| title | Lymph node metastasis from melanoma with an unknown primary site |
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