MARKEDLY ELEVATED MATERNAL SERUM ALPHA-FETOPROTEIN ASSOCIATED WITH A NORMAL FETUS AND CHORIOCARCINOMA OF THE PLACENTA
Determination of maternal serum alpha-fetoprotein (MSAFP) has become an important screening test for a variety of fetal and maternal abnormalities. A 33-year-old multiparous white woman had a markedly elevated MSAFP level (140 multiples of the median). Extensive antepartum work-up for fetal anomalie...
Gespeichert in:
| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1990-09, Vol.76 (3, Part 2 Suppl), p.494-497 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 497 |
|---|---|
| container_issue | 3, Part 2 Suppl |
| container_start_page | 494 |
| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 76 |
| creator | Ollendorff, David A Goldberg, Jeffrey M Abu-Jawdeh, Graziella M Lurain, John R |
| description | Determination of maternal serum alpha-fetoprotein (MSAFP) has become an important screening test for a variety of fetal and maternal abnormalities. A 33-year-old multiparous white woman had a markedly elevated MSAFP level (140 multiples of the median). Extensive antepartum work-up for fetal anomalies, fetal-maternal transfusion, or maternal etiology revealed no explanation. The patient subsequently delivered a healthy male infant. Pathologic examination of the placenta demonstrated a small, discrete area of choriocarcinoma. Computed tomography showed a solitary pulmonary metastasis. Because the patient did not desire future pregnancies, a total abdominal hysterectomy was performed, followed by four courses of EMA-CO chemotherapy. Her serum hCG levels subsequently became undetectable. Choriocarcinoma of the placenta must be considered in the differential diagnosis of an otherwise unexplained elevated MSAFP level. (Obstet Gynecol 76494, 1990) |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_79930507</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79930507</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2816-318d1680286d7d89f3147832d479583eda11b091e58ca8e5affb88d4e1382ec53</originalsourceid><addsrcrecordid>eNpFkFtr4zAQhcXS0qbZ_QkLetm-GXSxLelROMrarG0Fx9nLk1FsmabrNFkrpuy_r0gNhWEG5nxnGM4nsMCc0YBQ-vsGLBAiImA8DO_Bg3PPCCEcC3oH7vyIacwWYCpk9UOt8j9Q5eqnrNUKFr5XpczhVlW7Asp8k8pgrWq9qXStshLK7VYn2ZX9ldUplLDUVeENHtptoSxXMEl1lelEVklW6kJCvYZ1quAml4kqa_kZ3PZmcPbLPJdg571JGuT6e5bIPDgTjuOAYt7hmCPC4451XPQUh4xT0oVMRJzazmC8RwLbiLeG28j0_Z7zLrSYcmLbiC7B4_vd83j6N1l3aY4H19phMC_2NLmGCUFRhJgHv87gtD_arjmPh6MZ_zdzTl7_NuvGtWboR_PSHtwHJkjImX9tCcJ37vU0XOzo_g7Tqx2bJ2uGy1Pj80cxiVCAhUDIFwmuK_oGmDR2sQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79930507</pqid></control><display><type>article</type><title>MARKEDLY ELEVATED MATERNAL SERUM ALPHA-FETOPROTEIN ASSOCIATED WITH A NORMAL FETUS AND CHORIOCARCINOMA OF THE PLACENTA</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Ollendorff, David A ; Goldberg, Jeffrey M ; Abu-Jawdeh, Graziella M ; Lurain, John R</creator><creatorcontrib>Ollendorff, David A ; Goldberg, Jeffrey M ; Abu-Jawdeh, Graziella M ; Lurain, John R</creatorcontrib><description>Determination of maternal serum alpha-fetoprotein (MSAFP) has become an important screening test for a variety of fetal and maternal abnormalities. A 33-year-old multiparous white woman had a markedly elevated MSAFP level (140 multiples of the median). Extensive antepartum work-up for fetal anomalies, fetal-maternal transfusion, or maternal etiology revealed no explanation. The patient subsequently delivered a healthy male infant. Pathologic examination of the placenta demonstrated a small, discrete area of choriocarcinoma. Computed tomography showed a solitary pulmonary metastasis. Because the patient did not desire future pregnancies, a total abdominal hysterectomy was performed, followed by four courses of EMA-CO chemotherapy. Her serum hCG levels subsequently became undetectable. Choriocarcinoma of the placenta must be considered in the differential diagnosis of an otherwise unexplained elevated MSAFP level. (Obstet Gynecol 76494, 1990)</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 1696367</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adult ; alpha-Fetoproteins - analysis ; Biological and medical sciences ; Choriocarcinoma - diagnosis ; Choriocarcinoma - pathology ; Choriocarcinoma - surgery ; Diagnosis, Differential ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Hysterectomy ; Lung Neoplasms - secondary ; Medical sciences ; Placenta Diseases - diagnosis ; Placenta Diseases - pathology ; Placenta Diseases - surgery ; Pregnancy ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1990-09, Vol.76 (3, Part 2 Suppl), p.494-497</ispartof><rights>1990 The American College of Obstetricians and Gynecologists</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19248778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1696367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ollendorff, David A</creatorcontrib><creatorcontrib>Goldberg, Jeffrey M</creatorcontrib><creatorcontrib>Abu-Jawdeh, Graziella M</creatorcontrib><creatorcontrib>Lurain, John R</creatorcontrib><title>MARKEDLY ELEVATED MATERNAL SERUM ALPHA-FETOPROTEIN ASSOCIATED WITH A NORMAL FETUS AND CHORIOCARCINOMA OF THE PLACENTA</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Determination of maternal serum alpha-fetoprotein (MSAFP) has become an important screening test for a variety of fetal and maternal abnormalities. A 33-year-old multiparous white woman had a markedly elevated MSAFP level (140 multiples of the median). Extensive antepartum work-up for fetal anomalies, fetal-maternal transfusion, or maternal etiology revealed no explanation. The patient subsequently delivered a healthy male infant. Pathologic examination of the placenta demonstrated a small, discrete area of choriocarcinoma. Computed tomography showed a solitary pulmonary metastasis. Because the patient did not desire future pregnancies, a total abdominal hysterectomy was performed, followed by four courses of EMA-CO chemotherapy. Her serum hCG levels subsequently became undetectable. Choriocarcinoma of the placenta must be considered in the differential diagnosis of an otherwise unexplained elevated MSAFP level. (Obstet Gynecol 76494, 1990)</description><subject>Adult</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biological and medical sciences</subject><subject>Choriocarcinoma - diagnosis</subject><subject>Choriocarcinoma - pathology</subject><subject>Choriocarcinoma - surgery</subject><subject>Diagnosis, Differential</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Lung Neoplasms - secondary</subject><subject>Medical sciences</subject><subject>Placenta Diseases - diagnosis</subject><subject>Placenta Diseases - pathology</subject><subject>Placenta Diseases - surgery</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFtr4zAQhcXS0qbZ_QkLetm-GXSxLelROMrarG0Fx9nLk1FsmabrNFkrpuy_r0gNhWEG5nxnGM4nsMCc0YBQ-vsGLBAiImA8DO_Bg3PPCCEcC3oH7vyIacwWYCpk9UOt8j9Q5eqnrNUKFr5XpczhVlW7Asp8k8pgrWq9qXStshLK7VYn2ZX9ldUplLDUVeENHtptoSxXMEl1lelEVklW6kJCvYZ1quAml4kqa_kZ3PZmcPbLPJdg571JGuT6e5bIPDgTjuOAYt7hmCPC4451XPQUh4xT0oVMRJzazmC8RwLbiLeG28j0_Z7zLrSYcmLbiC7B4_vd83j6N1l3aY4H19phMC_2NLmGCUFRhJgHv87gtD_arjmPh6MZ_zdzTl7_NuvGtWboR_PSHtwHJkjImX9tCcJ37vU0XOzo_g7Tqx2bJ2uGy1Pj80cxiVCAhUDIFwmuK_oGmDR2sQ</recordid><startdate>199009</startdate><enddate>199009</enddate><creator>Ollendorff, David A</creator><creator>Goldberg, Jeffrey M</creator><creator>Abu-Jawdeh, Graziella M</creator><creator>Lurain, John R</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199009</creationdate><title>MARKEDLY ELEVATED MATERNAL SERUM ALPHA-FETOPROTEIN ASSOCIATED WITH A NORMAL FETUS AND CHORIOCARCINOMA OF THE PLACENTA</title><author>Ollendorff, David A ; Goldberg, Jeffrey M ; Abu-Jawdeh, Graziella M ; Lurain, John R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2816-318d1680286d7d89f3147832d479583eda11b091e58ca8e5affb88d4e1382ec53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biological and medical sciences</topic><topic>Choriocarcinoma - diagnosis</topic><topic>Choriocarcinoma - pathology</topic><topic>Choriocarcinoma - surgery</topic><topic>Diagnosis, Differential</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Lung Neoplasms - secondary</topic><topic>Medical sciences</topic><topic>Placenta Diseases - diagnosis</topic><topic>Placenta Diseases - pathology</topic><topic>Placenta Diseases - surgery</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ollendorff, David A</creatorcontrib><creatorcontrib>Goldberg, Jeffrey M</creatorcontrib><creatorcontrib>Abu-Jawdeh, Graziella M</creatorcontrib><creatorcontrib>Lurain, John R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ollendorff, David A</au><au>Goldberg, Jeffrey M</au><au>Abu-Jawdeh, Graziella M</au><au>Lurain, John R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MARKEDLY ELEVATED MATERNAL SERUM ALPHA-FETOPROTEIN ASSOCIATED WITH A NORMAL FETUS AND CHORIOCARCINOMA OF THE PLACENTA</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1990-09</date><risdate>1990</risdate><volume>76</volume><issue>3, Part 2 Suppl</issue><spage>494</spage><epage>497</epage><pages>494-497</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Determination of maternal serum alpha-fetoprotein (MSAFP) has become an important screening test for a variety of fetal and maternal abnormalities. A 33-year-old multiparous white woman had a markedly elevated MSAFP level (140 multiples of the median). Extensive antepartum work-up for fetal anomalies, fetal-maternal transfusion, or maternal etiology revealed no explanation. The patient subsequently delivered a healthy male infant. Pathologic examination of the placenta demonstrated a small, discrete area of choriocarcinoma. Computed tomography showed a solitary pulmonary metastasis. Because the patient did not desire future pregnancies, a total abdominal hysterectomy was performed, followed by four courses of EMA-CO chemotherapy. Her serum hCG levels subsequently became undetectable. Choriocarcinoma of the placenta must be considered in the differential diagnosis of an otherwise unexplained elevated MSAFP level. (Obstet Gynecol 76494, 1990)</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>1696367</pmid><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1990-09, Vol.76 (3, Part 2 Suppl), p.494-497 |
| issn | 0029-7844 1873-233X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79930507 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult alpha-Fetoproteins - analysis Biological and medical sciences Choriocarcinoma - diagnosis Choriocarcinoma - pathology Choriocarcinoma - surgery Diagnosis, Differential Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Hysterectomy Lung Neoplasms - secondary Medical sciences Placenta Diseases - diagnosis Placenta Diseases - pathology Placenta Diseases - surgery Pregnancy Pregnancy Outcome Pregnancy. Fetus. Placenta |
| title | MARKEDLY ELEVATED MATERNAL SERUM ALPHA-FETOPROTEIN ASSOCIATED WITH A NORMAL FETUS AND CHORIOCARCINOMA OF THE PLACENTA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T03%3A54%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MARKEDLY%20ELEVATED%20MATERNAL%20SERUM%20ALPHA-FETOPROTEIN%20ASSOCIATED%20WITH%20A%20NORMAL%20FETUS%20AND%20CHORIOCARCINOMA%20OF%20THE%20PLACENTA&rft.jtitle=Obstetrics%20and%20gynecology%20(New%20York.%201953)&rft.au=Ollendorff,%20David%20A&rft.date=1990-09&rft.volume=76&rft.issue=3,%20Part%202%20Suppl&rft.spage=494&rft.epage=497&rft.pages=494-497&rft.issn=0029-7844&rft.eissn=1873-233X&rft.coden=OBGNAS&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E79930507%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79930507&rft_id=info:pmid/1696367&rfr_iscdi=true |