Novel germline mutations of hMSH2 in a patient with hereditary nonpolyposis colorectal cancer (HNPCC) and in a patient with six primary cancers

We screened for germline mutations of mismatch repair genes, hMLH1 and hMSH2 , in five Japanese families carrying hereditary nonpolyposis colorectal cancer (HNPCC) and in a patient with multiple primary cancers. Screening the entire coding regions of both genes using polymerase chain reaction-single...

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Veröffentlicht in:	Journal of human genetics 1998-01, Vol.43 (2), p.143-145
Hauptverfasser:	Okamura, S., Koyama, K., Miyoshi, Yasuo, Monden, Morito, Takami, Motohisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedicine Brief report — Mutation report brief-report Carcinoma - genetics Colonic Neoplasms - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Mutational Analysis DNA Repair - genetics DNA, Neoplasm - genetics DNA-Binding Proteins Endometrial Neoplasms - genetics Female Frameshift Mutation Gene Expression Gene Function Gene Therapy Germ-Line Mutation Human Genetics Humans Ileal Neoplasms - genetics Intestinal Neoplasms - genetics Japan Molecular Medicine MutS Homolog 2 Protein Neoplasm Proteins - genetics Neoplasms, Multiple Primary - genetics Neoplasms, Second Primary - genetics Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Proto-Oncogene Proteins - genetics Rectal Neoplasms - genetics Sigmoid Neoplasms - genetics
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