Antimalarial activity of a 4', 5'-unsaturated 5'- fluoroadenosine mechanism-based inhibitor of s-adenosyl- l-homocysteine hydrolase

A 4',5'-unsaturated 5'-fluoroadenosine inhibitor of S-adenosyl- l-homocysteine hydrolase (SAH hydrolase; EC 3.3.1.1), MDL 28842, was found to inhibit markedly the growth of Plasmodium falciparum in vitro and Plasmodium berghei in mice. Inhibition of P. berghei growth was associated wi...

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Veröffentlicht in:	Biochemical pharmacology 1990-08, Vol.40 (3), p.601-606
Hauptverfasser:	Bitonti, Alan J., Baumann, Russell J., Jarvi, Esa T., McCarthy, James R., Mccann, Peter P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine - therapeutic use Adenosylhomocysteinase Animals Antimalarials - pharmacology Antimalarials - therapeutic use antiviral agents Erythrocytes - metabolism Hydrolases - antagonists & inhibitors Hydrolases - blood Malaria - blood Malaria - drug therapy Molecular Structure Plasmodium berghei Plasmodium berghei - drug effects Plasmodium berghei - growth & development Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - growth & development S-adenosyl-L-homocysteine hydrolase S-Adenosylhomocysteine - blood
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